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Epidemiology & Infection Epidemiology & Infection

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A first molecular epidemiological study of SAT-2 type foot-and-mouth disease viruses in West Africa

Published online by Cambridge University Press:  12 May 2004

O. SANGARÉ ,
A. D. S. BASTOS ,
E. H. VENTER  and
W. VOSLOO
O. SANGARÉ
Affiliation:
ARC-OVI, Exotic Diseases Division, Onderstepoort 0110, South Africa Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, South Africa
A. D. S. BASTOS
Affiliation:
Mammal Research Institute, Department of Zoology & Entomology, University of Pretoria, Pretoria 0002, South Africa
E. H. VENTER
Affiliation:
Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, South Africa
W. VOSLOO
Affiliation:
ARC-OVI, Exotic Diseases Division, Onderstepoort 0110, South Africa
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Abstract

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Thirty-one viruses causing SAT-2 outbreaks in seven West African countries between 1974 and 1991, and four viruses representative of East and Central Africa were genetically characterized in this study. Four major viral lineages (I–IV) were identified by phylogenetic analysis of an homologous 480 nucleotide region corresponding to the C-terminus end of VP1. Lineage I comprised two West African genotypes with viruses clustering according to year of isolation rather than geographical origin. Lineage II was represented by viruses isolated between 1979 and 1983 in two neighbouring West African countries, Senegal and The Gambia. Viruses from Nigeria and Eritrea, representative of West and East Africa respectively, constituted lineage III, whilst lineage IV, comprising viruses from Central and East Africa, was regionally and genetically distinct. This study revealed that unrestricted animal movement in West Africa is a major factor in disease dissemination and has also provided the first indication of trans-regional virus transmission.

Type
Research Article
Information
Epidemiology & Infection , Volume 132 , Issue 3 , June 2004 , pp. 525 - 532
Copyright
© 2004 Cambridge University Press
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