Skip to main content Accessibility help
×
Home

High expression levels of influenza virus receptors in airway of the HBV-transgenic mice

  • Jiajun Yang (a1), Hao Li (a2), Liyuan Jia (a1), Xianchun Lan (a1), Yuhui Zhao (a1) (a3), Huijie Bian (a2) and Zheng Li (a1)...

Abstract

In the human population, influenza A viruses are associated with acute respiratory illness and are responsible for millions of deaths annually. Avian and human influenza viruses typically have a different α2-3- and α2-6-linked sialic acid (SA) binding preference. Only a few amino acid changes in the haemagglutinin on the surface of avian influenza viruses (AIV) can cause a switch from avian to human receptor specificity, and the individuals with pathognostic chronic diseases might be more susceptible to AIV due to the decreased expression level of terminal α2-3-linked SA in their saliva. Here, using lectin and virus histochemical staining, we observed the higher expression levels of α2-3/6-linked SA influenza virus receptors in the airway of HBV-transgenic mice compared with that of control mice due to the significant decrease in control mice during ageing, which imply that this is also a risk factor for individuals with pathognostic chronic diseases susceptible to influenza viruses. Our findings will help understand the impact on influenza virus pathogenesis and transmission.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      High expression levels of influenza virus receptors in airway of the HBV-transgenic mice
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      High expression levels of influenza virus receptors in airway of the HBV-transgenic mice
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      High expression levels of influenza virus receptors in airway of the HBV-transgenic mice
      Available formats
      ×

Copyright

This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.

Corresponding author

Author for correspondence: Zheng Li, E-mail: zhengli@nwu.edu.cn

Footnotes

Hide All
*

These authors contributed equally to this work.

Footnotes

References

Hide All
1.Wohlbold, TJ and Krammer, F (2014) In the shadow of hemagglutinin: a growing interest in influenza viral neuraminidase and its role as a vaccine antigen. Viruses 6, 24652494.
2.Byrd-Leotis, L, Cummings, RD and Steinhauer, DA (2017) The interplay between the host receptor and influenza virus hemagglutinin and neuraminidase. International Journal of Molecular Sciences 18, 1541.
3.Subbarao, K et al. (1998) Characterization of an avian influenza A (H5N1) virus isolated from a child with a fatal respiratory illness. Science 279, 393396.
4.Claas, EC et al. (1998) Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus. Lancet 351, 472477.
5.Fouchier, RA et al. (2004) Avian influenza A virus (H7N7) associated with human conjunctivitis and a fatal case of acute respiratory distress syndrome. Proceedings of the National Academy of Sciences 101, 13561361.
6.Rogers, G and Paulson, JC (1983) Receptor determinants of human and animal influenza virus isolates: differences in receptor specificity of the H3 hemagglutinin based on species of origin. Virology 127, 361373.
7.Rogers, GN et al. (1983) Single amino acid substitutions in influenza haemagglutinin change receptor binding specificity. Nature 304, 7678.
8.Beigel, JH et al. (2005) Avian influenza A (H5N1) infection in humans. New England Journal of Medicine 353, 13741385.
9.Van Riel, D et al. (2007) Human and avian influenza viruses target different cells in the lower respiratory tract of humans and other mammals. American Journal of Pathology 171, 12151223.
10.Pyhälä, R et al. (1988) Host cell-mediated selection of influenza A (H3N2) virus variant subpopulations: lack of association between antigenic and receptor-binding properties. Epidemiology & Infection 100, 511522.
11.Van Riel, D et al. (2010) Seasonal and pandemic human influenza viruses attach better to human upper respiratory tract epithelium than avian influenza viruses. American Journal of Pathology 176, 16141618.
12.Couceiro, JN, Paulson, JC and Baum, LG (1983) Influenza virus strains selectively recognize sialyloligosaccharides on human respiratory epithelium; the role of the host cell in selection of hemagglutinin receptor specificity. Virus Research 29, 155165.
13.Baum, LG and Paulson, JC (1990) Sialyloligosaccharides of the respiratory epithelium in the selection of human influenza virus receptor specificity. Acta Histochemica. Supplementband 40, 3538.
14.Shinya, K et al. (2006) Avian flu: influenza virus receptors in the human airway. Nature 440, 435436.
15.Van Hoeven, N et al. (2009) Human HA and polymerase subunit PB2 proteins confer transmission of an avian influenza virus through the air. Proceedings of the National Academy of Sciences of the United States of America 106, 33663371.
16.Lamblin, G and Rousse, P (1993) Airway mucins and their role in defence against micro-organisms. Respiratory Medicine 87, 421426.
17.Breg, J et al. (1987) Structure of sialyl-oligosaccharides isolated from bronchial mucus glycoproteins of patients (blood group O) suffering from cystic fibrosis. European Journal of Biochemistry 168, 5768.
18.Limsuwat, N et al. (2014) Susceptibility of human and avian influenza viruses to human and chicken saliva. Journal of Medical Virology 86, 872878.
19.Hartshorn, KL et al. (1994) Evidence for a protective role of pulmonary surfactant protein D (SP-D) against influenza A viruses. Journal of Clinical Investigation 94, 311319.
20.Hartshorn, KL et al. (2000) Mechanism of binding of surfactant protein D to influenza A viruses: importance of binding to haemagglutin in to antiviral activity. Biochemical Journal 351, 449458.
21.Hsieh, IN et al. (2018) The role and molecular mechanism of action of surfactant protein D in innate host defense against influenza A virus. Frontiers in Immunology 9, 1368.
22.Chen, CH et al. (2010) The essentiality of α-2-macroglobulin in human salivary innate immunity against new H1N1 swine origin influenza A virus. Proteomics 10, 23962401.
23.Josset, L et al. (2012) Increased viral loads and exacerbated innate host responses in aged macaques infected with the 2009 pandemic H1N1 influenza A virus. Journal of Virology 86, 1111511127.
24.Hartshorn, KL et al. (2006) Salivary agglutinin and lung scavenger receptor cysteine-rich glycoprotein 340 have broad anti-influenza activities and interactions with surfactant protein D that vary according to donor source and sialylation. Biochemical Journal 393, 543553.
25.Verma, N et al. (2012) Influenza virus H1N1pdm09 infections in the young and old: evidence of greater antibody diversity and affinity for the hemagglutinin globular head domain (HA1 domain) in the elderly than in young adults and children. Journal of Virology 86, 55155522.
26.Qin, Y et al. (2013) Age- and sex-associated differences in the glycopatterns of human salivary glycoproteins and their roles against influenza A virus. Journal of Proteome Research 12, 27422754.
27.People with Health Conditions. Available at http://www.flu.gov/at-risk/health-conditions/ (Accessed 17 September 2017).
28.Schanzer, DL, Langley, JM and Tam, TW (2008) Co-morbidities associated with influenza-attributed mortality, 1994–2000, Canada. Vaccine 26, 46974703.
29.Tsui, HY et al. (2013) Prevalence of seasonal influenza vaccination and associated factors in people with chronic diseases in Hong Kong. Epidemiology & Infection 141, 377389.
30.Hak, E et al. (2005) Clinical effectiveness of influenza vaccination in persons younger than 65 years with high-risk medical conditions: the PRISMA study. Archives Internal Medicine 165, 274280.
31.Zhong, Y et al. (2015) avian influenza virus infection risk in humans with chronic diseases. Scientific Reports 5, 8971.
32.Chisari, FV et al. (1989) Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice. Cell 59, 11451156.
33.Yu, H et al. (2018) Characterization of proteins with Siaα2-3/6Gal-linked glycans from bovine milk and role of their glycans against influenza A virus. Food & Function 9, 51985208.
34.Li, Y et al. (2013) Immunogenicity and safety of a 2009 pandemic influenza A (H1N1) monovalent vaccine in Chinese infants aged 6–35 months: a randomized, doubleblind, controlled phase I clinical trial. Influenza and Other Respiratory Viruses 7, 12971307.
35.Qin, Y et al. (2012) Alteration of protein glycosylation in human hepatic stellate cells activated with transforming growth factor-β1. Journal of Proteomics 75, 41144123.
36.De Graaf, M and Fouchier, RA (2014) Role of receptor binding specificity in influenza A virus transmission and pathogenesis. EMBO Journal 33, 823841.
37.Chan, RW et al. (2013) Use of ex vivo and in vitro cultures of the human respiratory tract to study the tropism and host responses of highly pathogenic avian influenza A (H5N1) and other influenza viruses. Virus Research 178, 133145.
38.Rimmelzwaan, GF et al. (2007) Attachment of infectious influenza A viruses of various subtypes to live mammalian and avian cells as measured by flow cytometry. Virus Research 129, 175181.
39.Nicholls, JM et al. (2007) Sialic acid receptor detection in the human respiratory tract: evidence for widespread distribution of potential binding sites for human and avian influenza viruses. Respiratory Research 8, 73.
40.Ning, ZY et al. (2009) Detection of expression of influenza virus receptors in tissues of BALB/c mice by histochemistry. Veterinary Research Communications 33, 895903.
41.Smrt, ST and Lorieau, JL (2017) Membrane fusion and infection of the influenza hemagglutinin. Advances in Experimental Medicine and Biology 966, 3754.
42.Eriksson, P et al. (2019) Attachment patterns of human and avian influenza viruses to trachea and colon of 26 bird species – support for the community concept. Frontiers in Microbiology 10, 815.
43.Grohskopf, L, Sokolow, L and Broder, K (2016) Prevention and control of seasonal influenza with vaccines recommendations of the advisory committee on immunization practices-United States, 2016–17 influenza season. Morbidity and Mortality Weekly Report 65, 154.
44.Grohskopf, LA et al. (2017) Prevention and control of seasonal influenza with vaccines: recommendations of the advisory committee on immunization practices-United States, 2017–18 influenza season. Morbidity and Mortality Weekly Report 66, 120.
45.Cox, CM et al. (2012) Increase in rates of hospitalization due to laboratory-confirmed influenza among children and adults during the 2009–10 influenza pandemic. Journal of Infectious Diseases 206, 13501358.
46.Homaira, N et al. (2019) Impact of influenza on hospitalization rates in children with a range of chronic lung diseases. Influenza and Other Respiratory Viruses 13, 233239.
47.Neuzil, KM et al. (2000) The burden of influenza illness in children with asthma and other chronic medical conditions. Journal of Pediatrics 137, 856864.

Keywords

High expression levels of influenza virus receptors in airway of the HBV-transgenic mice

  • Jiajun Yang (a1), Hao Li (a2), Liyuan Jia (a1), Xianchun Lan (a1), Yuhui Zhao (a1) (a3), Huijie Bian (a2) and Zheng Li (a1)...

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed