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    Sanz, Ivan Rojo, Silvia Tamames, Sonia Eiros, José and Ortiz de Lejarazu, Raúl 2017. Heterologous Humoral Response against H5N1, H7N3, and H9N2 Avian Influenza Viruses after Seasonal Vaccination in a European Elderly Population. Vaccines, Vol. 5, Issue. 3, p. 17.
    Sarateanu, D.E Ehrengut, W Pressler, K Peukert, M and Schenk, K.D 1980. Serologic response to whole, split and subunit influenza vaccines of persons with and without immunological experience towards influenza A/U.S.S.R.90/77 virus. Comparative Immunology, Microbiology and Infectious Diseases, Vol. 3, Issue. 1-2, p. 225.
    Pyhälä, R. 1980. Protection by a polyvalent influenza vaccine and persistence of homologous and heterologous HI antibodies during a period of two epidemic seasons. Journal of Hygiene, Vol. 84, Issue. 02, p. 237.
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Homologous and heterologous antibody responses to subunit influenza virus vaccine

  • Brian J. Feery (a1), M. G. Evered (a1) and Kathleen Hayes (a2)
Summary

In a group of 32 adult volunteers given subunit influenza virus vaccine containing 250 international units (i.u.) of A/Victoria/3/75, 250 i.u. of A/Scotland/ 840/74 and 300 i.u. of B/Hong Kong/8/73, there were substantial increases in the geometric mean homologous haemagglutination-inhibiting (HI) antibody titres. There was also substantial boosting of the antibodies to the earlier variants of the Hong Kong (H3N2) series and to a later variant of the Asian (H2N2) series. There was no boosting of antibodies to the A/FM/1/47 strain, a representative member of the H1N1 series, but two individuals showed substantial rises to A/PR/8/34 (H0N1).

There were increases in the HI titre of antibodies cross reactive with two recent isolations, A/Texas/1/77, and A/Victoria/35/77, but the majority of vaccinees failed to reach antibody titres likely to be protective against such strains.

Copyright
COPYRIGHT: © Cambridge University Press 1978
References
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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
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