Skip to main content
×
Home
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 4
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Lindstrand, Ann Galanis, Ilias Darenberg, Jessica Morfeldt, Eva Naucler, Pontus Blennow, Margareta Alfvén, Tobias Henriques-Normark, Birgitta and Örtqvist, Åke 2016. Unaltered pneumococcal carriage prevalence due to expansion of non-vaccine types of low invasive potential 8years after vaccine introduction in Stockholm, Sweden. Vaccine,


    Miernyk, Karen M. Bulkow, Lisa R. Case, Samantha L. Zulz, Tammy Bruce, Michael G. Harker-Jones, Marcella Hurlburt, Debby A. Hennessy, Thomas W. and Rudolph, Karen M. 2016. Population structure of invasive Streptococcus pneumoniae isolates among Alaskan children in the conjugate vaccine era, 2001 to 2013. Diagnostic Microbiology and Infectious Disease,


    Nau, Roland Djukic, Marija Spreer, Annette Ribes, Sandra and Eiffert, Helmut 2015. Bacterial meningitis: an update of new treatment options. Expert Review of Anti-infective Therapy, Vol. 13, Issue. 11, p. 1401.


    Dando, Samantha J. Mackay-Sim, Alan Norton, Robert Currie, Bart J. St. John, James A. Ekberg, Jenny A. K. Batzloff, Michael Ulett, Glen C. and Beacham, Ifor R. 2014. Pathogens Penetrating the Central Nervous System: Infection Pathways and the Cellular and Molecular Mechanisms of Invasion. Clinical Microbiology Reviews, Vol. 27, Issue. 4, p. 691.


    ×

Laboratory surveillance of invasive pneumococcal disease in New South Wales, Australia, before and after introduction of 7-valent conjugate vaccine: reduced disease, but not antibiotic resistance rates

  • S. OFTADEH (a1), H. F. GIDDING (a1) (a2) and G. L. GILBERT (a1) (a3)
  • DOI: http://dx.doi.org/10.1017/S095026881200218X
  • Published online: 25 September 2012
Abstract
SUMMARY

We compared serotype distributions of Streptococcus pneumoniae isolates from patients aged <5 and ⩾5 years with invasive pneumococcal disease in New South Wales, Australia, and antibiotic susceptibilities of isolates from the <5 years age group only, before (2002–2004) and after (2005–2009) introduction of the 7-valent pneumococcal conjugate vaccine (PCV7). Overall, there were significant decreases in the mean annual number of referred isolates (770 vs. 515) and the proportion belonging to PCV7 serotypes (74% vs. 38%), but non-PCV7 serotypes, particularly 19A, increased (5% vs. 18%). All changes were more marked in the <5 years age group. Susceptibility testing of isolates from the <5 years age group showed variation in resistance between serotypes, but significant overall increases in penicillin non-susceptibility (23% vs. 31%), ceftriaxone resistance (2% vs. 12%) and multidrug resistance (4% vs. 7%) rates; erythromycin resistance fell (32% vs. 25%). Continued surveillance is needed to monitor changes following the introduction of 13-valent PCV in 2012.

Copyright
Corresponding author
*Author for correspondence: Dr S. Oftadeh, Centre for Infectious Diseases and Microbiology – Public Health (CIDM), Institute of Clinical Pathology and Medical Research (ICPMR), Westmead Hospital, Darcy Road, Westmead, New South Wales, 2145Australia. (Email: shahin.oftadeh@swahs.health.nsw.gov.au)
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

1.KL O'Brien , Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates. Lancet 2009; 374: 893902.

5.JA Bettinger , The effect of routine vaccination on invasive pneumococcal infections in Canadian children, Immunization Monitoring Program, Active 2000–2007. Vaccine 2010; 28: 21302136.

7.WH Liao , Impact of pneumococcal vaccines on invasive pneumococcal disease in Taiwan. European Journal of Clinical Microbiology and Infectious Diseases 2010; 29: 489492.

14.J Linares , Changes in antimicrobial resistance, serotypes and genotypes in Streptococcus pneumoniae over a 30-year period. Clinical Microbiology and Infection 2010; 16: 402410.

19.HE Hsu , Effect of pneumococcal conjugate vaccine on pneumococcal meningitis. New England Journal of Medicine 2009; 360: 244256.

20.SI Pelton , Emergence of 19A as virulent and multidrug resistant pneumococcus in Massachusetts following universal immunization of infants with pneumococcal conjugate vaccine. Pediatric Infectious Disease Journal 2007; 26: 468472.

31.AR Tunkel , Practice guidelines for the management of bacterial meningitis. Clinical Infectious Diseases 2004; 39: 12671284.

38.M Imohl , Temporal variations among invasive pneumococcal disease serotypes in children and adults in Germany (1992–2008). International Journal of Microbiology 2010; 2010: 121136.

39.EH Choi , Streptococcus pneumoniae serotype 19A in children, South Korea. Emerging Infectious Diseases 2008; 14: 275281.

41.X Xu , Distribution of serotypes, genotypes, and resistance determinants among macrolide-resistant Streptococcus pneumoniae isolates. Antimicrobial Agents and Chemotherapy 2010; 54: 11521159.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: