Skip to main content
×
Home
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 32
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Howie, Stephen R C 2016. Global Hib vaccination: reasons to cheer and fear. The Lancet Global Health, Vol. 4, Issue. 3, p. e142.


    Oikawa, Junko Ishiwada, Naruhiko Takahashi, Yoshiko Hishiki, Haruka Nagasawa, Koo Takahashi, Sachiko Watanabe, Masaharu Chang, Bin and Kohno, Yoichi 2014. Changes in nasopharyngeal carriage of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis among healthy children attending a day-care centre before and after official financial support for the 7-valent pneumococcal conjugate vaccine and H. influenzae type b vaccine in Japan. Journal of Infection and Chemotherapy, Vol. 20, Issue. 2, p. 146.


    Townsend, Kelly Ladhani, Shamez N. Findlow, Helen and Borrow, Ray 2014. Evaluation and validation of a serum bactericidal antibody assay for Haemophilus influenzae type b and the threshold of protection. Vaccine, Vol. 32, Issue. 43, p. 5650.


    van Hoek, Albert Jan Sheppard, Carmen L. Andrews, Nick J. Waight, Pauline A. Slack, Mary P.E. Harrison, Timothy G. Ladhani, Shamez N. and Miller, Elizabeth 2014. Pneumococcal carriage in children and adults two years after introduction of the thirteen valent pneumococcal conjugate vaccine in England. Vaccine, Vol. 32, Issue. 34, p. 4349.


    Collins, S. Ramsay, M. Campbell, H. Slack, M. P. E. and Ladhani, S. N. 2013. Invasive Haemophilus influenzae Type b Disease in England and Wales: Who Is at Risk After 2 Decades of Routine Childhood Vaccination?. Clinical Infectious Diseases, Vol. 57, Issue. 12, p. 1715.


    Howie, S. R. C. Oluwalana, C. Secka, O. Scott, S. Ideh, R. C. Ebruke, B. E. Balloch, A. Sambou, S. Erskine, J. Lowe, Y. Corrah, T. and Adegbola, R. A. 2013. The Effectiveness of Conjugate Haemophilus influenzae Type B Vaccine in The Gambia 14 Years After Introduction. Clinical Infectious Diseases, Vol. 57, Issue. 11, p. 1527.


    Yoshida, Lay-Myint Nguyen, Hien-Anh Watanabe, Kiwao Le, Minh Nhat Nguyen, Ai ThiThuy Vu, HuongThi Thu Yoshino, Hiroshi Suzuki, Motoi Takahashi, Kensuke Le, ThoHuu Moriuch, Hiroyuki Kilgore, Paul E. Edmond, Karen Mulholland, Kim Dang, Duc-Anh and Ariyoshi, Koya 2013. Incidence of Radiologically-Confirmed Pneumonia and Haemophilus influenzae Type b Carriage before Haemophilus influenzae Type b Conjugate Vaccine Introduction in Central Vietnam. The Journal of Pediatrics, Vol. 163, Issue. 1, p. S38.


    Garcia, Salvador Lagos, Rosanna Muñoz, Alma Picón, Teresa Rosa, Raquel Alfonso, Adriana Abriata, Graciela Gentile, Angela Romanin, Viviana Regueira, Mabel Chiavetta, Laura Agudelo, Clara Inés Castañeda, Elizabeth De la Hoz, Fernando Higuera, Ana Betty Arce, Patricia Cohen, Adam L. Verani, Jennifer Zuber, Patrick Gabastou, Jean-Marc Pastor, Desiree Flannery, Brendan and Andrus, Jon 2012. Impact of vaccination against Haemophilus influenzae type b with and without a booster dose on meningitis in four South American countries. Vaccine, Vol. 30, Issue. 2, p. 486.


    Gkentzi, Despoina Slack, Mary P.E. and Ladhani, Shamez N. 2012. The burden of nonencapsulated Haemophilus influenzae in children and potential for prevention. Current Opinion in Infectious Diseases, Vol. 25, Issue. 3, p. 266.


    Jackson, Michael L. Rose, Charles E. Cohn, Amanda Coronado, Fatima Clark, Thomas A. Wenger, Jay D. Bulkow, Lisa Bruce, Michael G. Messonnier, Nancy E. and Hennessy, Thomas W. 2012. Modeling Insights intoHaemophilus influenzaeType b Disease, Transmission, and Vaccine Programs. Emerging Infectious Diseases, Vol. 18, Issue. 1, p. 13.


    Khatami, Ameneh Snape, Matthew D. Wysocki, Jacek John, Tessa M. Westcar, Sharon Mesaros, Narcisa Peddiraju, Kavitha Boutriau, Dominigue Yu, Ly-Mee and Pollard, Andrew J. 2012. Persistence of Antibody Response Following a Booster Dose of Hib-MenC-TT Glycoconjugate Vaccine to Five Years. The Pediatric Infectious Disease Journal, p. 1.


    Ladhani, Shamez N. 2012. Two Decades of Experience With the Haemophilus influenzae Serotype b Conjugate Vaccine in the United Kingdom. Clinical Therapeutics, Vol. 34, Issue. 2, p. 385.


    Otsuka, Taketo Fujii, Koyata Okazaki, Minoru Komiyama, Kenichi Yoshida, Kazunaga Ishikawa, Yukio and Zaraket, Hassan 2012. Genotyping of Haemophilus influenzae type b in pre-vaccination era. Journal of Infection and Chemotherapy, Vol. 18, Issue. 2, p. 213.


    Visser, Adele and Hoosen, Anwar 2012. Haemophilus influenzae type b conjugate vaccines – A South African perspective. Vaccine, Vol. 30, p. C52.


    2012. Clinical Practice Guidelines for the Management of Bacterial Meningitis in Adults in Korea. Infection & Chemotherapy, Vol. 44, Issue. 3, p. 140.


    Jacups, Susan P 2011. The continuing role ofHaemophilus influenzaetype b carriage surveillance as a mechanism for early detection of invasive disease activity. Human Vaccines, Vol. 7, Issue. 12, p. 1254.


    Jacups, Susan P. Morris, Peter S. and Leach, Amanda J. 2011. Haemophilus influenzae type b carriage in Indigenous children and children attending childcare centers in the Northern Territory, Australia, spanning pre- and post-vaccine eras. Vaccine, Vol. 29, Issue. 16, p. 3083.


    Campbell, Helen Borrow, Ray Salisbury, David and Miller, Elizabeth 2009. Meningococcal C conjugate vaccine: The experience in England and Wales. Vaccine, Vol. 27, p. B20.


    Ladhani, Shamez Neely, Fiona Heath, Paul T. Nazareth, Bernadette Roberts, Richard Slack, Mary P.E. McVernon, Jodie and Ramsay, Mary E. 2009. Recommendations for the prevention of secondary Haemophilus influenzae type b (Hib) disease. Journal of Infection, Vol. 58, Issue. 1, p. 3.


    Dagan, Ron Poolman, Jan T and Zepp, Fred 2008. Combination vaccines containing DTPa–Hib: impact of IPV and coadministration of CRM197 conjugates. Expert Review of Vaccines, Vol. 7, Issue. 1, p. 97.


    ×

Long-term impact of vaccination on Haemophilus influenzae type b (Hib) carriage in the United Kingdom

  • J. McVERNON (a1), A. J. HOWARD (a2), M. P. E. SLACK (a3) and M. E. RAMSAY (a1)
  • DOI: http://dx.doi.org/10.1017/S0950268804002122
  • Published online: 01 July 2004
Abstract

A recent resurgence in serious infections due to Haemophilus influenzae type b (Hib) has been observed in the United Kingdom. More information on Hib transmission in the population is required in order to better understand the mechanism of this increase. The Public Health Laboratory Service (subsumed into the Health Protection Agency since April 2004) conducted four cross-sectional studies of asymptomatic oropharyngeal Hib carriage in children attending day-care nurseries in England and Wales in 1992, 1994, 1997 and 2002. These demonstrated a marked reduction in the prevalence of Hib colonization over time since vaccine introduction (3·98% in 1992; 0·70% in 1994; 0% in 1997; 0% in 2002), which did not explain the increase in invasive disease reports from 1999 onwards. We believe that a reduction in antibody levels over the first 5 years of life in immunized children in recent years has fuelled the rise in reported cases in the absence of an obvious increase in transmission.

Copyright
Corresponding author
Author for correspondence.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×