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    Dottori, M. and Fabricius, G. 2015. SIR model on a dynamical network and the endemic state of an infectious disease. Physica A: Statistical Mechanics and its Applications, Vol. 434, p. 25.

    Gaillard, María Emilia Bottero, Daniela Moreno, Griselda Rumbo, Martin Hozbor, Daniela and Carbonetti, Nicholas 2015. Strategies and new developments to control pertussis, an actual health problem: Graphical Abstract Figure.. Pathogens and Disease, Vol. 73, Issue. 8, p. ftv059.

    Pesco, P. Bergero, P. Fabricius, G. and Hozbor, D. 2015. Mathematical modeling of delayed pertussis vaccination in infants. Vaccine, Vol. 33, Issue. 41, p. 5475.

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    Pesco, P. Bergero, P. Fabricius, G. and Hozbor, D. 2014. Modelling the effect of changes in vaccine effectiveness and transmission contact rates on pertussis epidemiology. Epidemics, Vol. 7, p. 13.

    Chiappini, Elena Stival, Alessia Galli, Luisa and de Martino, Maurizio 2013. Pertussis re-emergence in the post-vaccination era. BMC Infectious Diseases, Vol. 13, Issue. 1,


Modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in Argentina

  • G. FABRICIUS (a1), P. E. BERGERO (a1), M. E. ORMAZABAL (a2), A. L. MALTZ (a3) and D. F. HOZBOR (a2)
  • DOI:
  • Published online: 06 July 2012

Due to the current epidemiological situation of pertussis, several countries have implemented vaccination strategies that include a booster dose for adolescents. Since there is still no evidence showing that the adolescent booster has a positive effect on the most vulnerable group represented by infants, it is difficult to universalize the recommendation to include such reinforcement. In this work we present an age-structured compartmental deterministic model that considers the outstanding epidemiological features of the disease in order to assess the impact of the booster dose at age 11 years (Tdap booster) to infants. To this end, we performed different parameterizations of the model that represent distinct possible epidemiological scenarios. The results obtained show that the inclusion of a single Tdap dose at age 11 years significantly reduces the incidence of the disease within this age group, but has a very low impact on the risk group (0–1 year). An effort to improve the coverage of the first dose would have a much greater impact on infants. These results hold in the 18 scenarios considered, which demonstrates the robustness of these conclusions.

Corresponding author
*Author for correspondence: Dr G. Fabricius, Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas, Diagonal 113 y 64, Cc. 16, Suc. 4, 1900 La Plata, Argentina. (Email:
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Epidemiology & Infection
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