Skip to main content
×
×
Home

Progressive increase in community-associated methicillin-resistant Staphylococcus aureus in Indigenous populations in northern Australia from 1993 to 2012

  • S. Y. C. TONG (a1), L. VARRONE (a1), M. D. CHATFIELD (a1), M. BEAMAN (a2) and P. M. GIFFARD (a1)...
Summary

Hospital-based studies have determined high rates of community-associated methicillin-resistant Staphylococcus aureus (MRSA) in Indigenous populations. However, there is a paucity of community-based data. We obtained 20 years (1993–2012) of data on S. aureus isolates (N = 20 210) collected from community clinics that provide services for Indigenous communities in the Northern Territory, Australia. Methicillin resistance increased from 7% to 24%, resistance to macrolides remained stable at ~25%, and there was a slight increase in resistance to trimethoprim-sulfamethoxazole. The increase in methicillin resistance is concerning for the Indigenous communities represented by this data, but it is also of significance if virulent MRSA clones emerge and spread more widely from such settings.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Progressive increase in community-associated methicillin-resistant Staphylococcus aureus in Indigenous populations in northern Australia from 1993 to 2012
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Progressive increase in community-associated methicillin-resistant Staphylococcus aureus in Indigenous populations in northern Australia from 1993 to 2012
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Progressive increase in community-associated methicillin-resistant Staphylococcus aureus in Indigenous populations in northern Australia from 1993 to 2012
      Available formats
      ×
Copyright
Corresponding author
* Author for correspondence: Dr S. Y. C. Tong, Menzies School of Health Research, PO Box 40196, Casuarina, NT, 0810, Australia. (Email: Steven.Tong@menzies.edu.au)
References
Hide All
1. World Health Organization. Antimicrobial resistance: global report on surveillance (http://www.who.int/drugresistance/documents/surveillancereport/en/), 2014. Accessed 19 May 2014.
2. Tong, SY, Chen, LF, Fowler, VG. Jr. Colonization, pathogenicity, host susceptibility, and therapeutics for Staphylococcus aureus: what is the clinical relevance? Seminars in Immunopathology 2012; 34: 185200.
3. Chambers, HF, Deleo, FR. Waves of resistance: Staphylococcus aureus in the antibiotic era. Nature Reviews Microbiology 2009; 7: 629641.
4. Udo, EE, Pearman, JW, Grubb, WB. Genetic analysis of community isolates of methicillin-resistant Staphylococcus aureus in Western Australia. Journal of Hospital Infection 1993; 25: 97108.
5. Tong, SY, et al. Community-associated strains of methicillin-resistant Staphylococcus aureus and methicillin-susceptible S. aureus in Indigenous northern Australia: epidemiology and outcomes. Journal of Infectious Diseases 2009; 199: 14611470.
6. Coombs, GW, et al. Prevalence of MRSA strains among Staphylococcus aureus isolated from outpatients, 2006. Communicable Disease Intelligence 2009; 33: 1020.
7. Bell, SM, Gatus, BJ, Pham, JN. The Calibrated Dichotomous Sensitivity (CDS) test. Microbiology Australia 2000; 21: 2324.
8. McMeniman, E, et al. Skin disease in the first two years of life in Aboriginal children in East Arnhem Land. Australasian Journal of Dermatology 2011; 52: 270273.
9. Tong, SY, et al. Clinical correlates of Panton-Valentine leukocidin (PVL), PVL isoforms, and clonal complex in the Staphylococcus aureus population of Northern Australia. Journal of Infectious Diseases 2010; 202: 760769.
10. Tong, SY, et al. Global implications of the emergence of community-associated methicillin-resistant Staphylococcus aureus in Indigenous populations. Clinical Infectious Diseases 2008; 46: 18711878.
11. Stinear, TP, et al. Adaptive change inferred from genomic population analysis of the ST93 epidemic clone of community-associated methicillin-resistant Staphylococcus aureus . Genome Biology and Evolution 2014; 6: 366378.
12. Valery, PC, et al. Long-term azithromycin for Indigenous children with non-cystic-fibrosis bronchiectasis or chronic suppurative lung disease (Bronchiectasis Intervention Study): a multicentre, double-blind, randomised controlled trial. Lancet Respiratory Medicine 2013; 1: 610620.
13. Bowen, AC, et al. Short-course oral co-trimoxazole versus intramuscular benzathine benzylpenicillin for impetigo in a highly endemic region: an open-label, randomised, controlled, non-inferiority trial. Lancet. Published online: 27 August 2014 . doi:10.1016/S0140-6736(14)60841-2.
14. Tong, SY, Kearns, AM. Community-associated MRSA from the Indian subcontinent. Lancet Infectious Diseases 2013; 13: 734735.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Epidemiology & Infection
  • ISSN: -
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed