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Rapid assessment of influenza vaccine effectiveness: analysis of an internet-based cohort

  • K. T. D. EAMES (a1), E. BROOKS-POLLOCK (a1), D. PAOLOTTI (a2), M. PEROSA (a2), C. GIOANNINI (a2) and W. J. EDMUNDS (a1)...
Abstract
SUMMARY

The effectiveness of influenza vaccination programmes is seldom known during an epidemic. We developed an internet-based system to record influenza-like symptoms and response to infection in a participating cohort. Using self-reports of influenza-like symptoms and of influenza vaccine history and uptake, we estimated vaccine effectiveness (VE) without the need for individuals to seek healthcare. We found that vaccination with the 2010 seasonal influenza vaccine was significantly protective against influenza-like illness (ILI) during the 2010–2011 influenza season (VE 52%, 95% CI 27–68). VE for individuals who received both the 2010 seasonal and 2009 pandemic influenza vaccines was 59% (95% CI 27–77), slightly higher than VE for those vaccinated in 2010 alone (VE 46%, 95% CI 9–68). Vaccinated individuals with ILI reported taking less time off work than unvaccinated individuals with ILI (3·4 days vs. 5·3 days, P<0·001).

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Corresponding author
*Author for correspondence: Dr K. T. D. Eames, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK. (Email: Ken.Eames@lshtm.ac.uk)
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2. M Valenciano , Study designs for timely estimation of influenza vaccine effectiveness using European sentinel practitioner networks. Vaccine 2010; 28: 73817388.

4. DM Skowronski , Estimating vaccine effectiveness against laboratory-confirmed influenza using a sentinel physician network: results from the 2005–2006 season of dual A and B vaccine mismatch in Canada. Vaccine 2007; 25: 28422851.

8. C Savulescu , Estimating the influenza vaccine effectiveness in elderly on a yearly basis using the Spanish influenza surveillance network – pilot case-control studies using different control groups, 2008–2009 season, Spain. Vaccine 2010; 28: 29032907.

10. E Brooks-Pollock , Using an online survey of healthcare-seeking behaviour to estimate the magnitude and severity of the 2009 H1N1v influenza epidemic in England. BMC Infectious Diseases 2011; 11: 68.

11. N Tilston , Internet-based surveillance of Influenza-like-illness in the UK during the 2009 H1N1 influenza pandemic. BMC Public Health 2010; 10: 650.

12. I Friesma , Internet-based monitoring of influenza-like illness in the general population: experience of five influenza seasons in the Netherlands. Vaccine 2009; 27: 63536357.

13. LA McNutt , Estimating the relative risk in cohort studies and clinical trials of common outcomes. American Journal of Epidemiology 2003; 157: 940943

14. G Zou . A modified Poisson regression approach to prospective studies with binary data. American Journal of Epidemiology 2004; 159: 702706.

16. R Ihaka , R Gentleman . R: A language for data analysis and graphics. Journal of Computational and Graphical Statistics 1996; 5: 299314.

19. CB Bridges , Effectiveness and cost-benefit of influenza vaccination of healthy working adults. Journal of the American Medical Association 2000; 284: 16551663.

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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
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