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    Chun Hong, H.S. Steltenkamp, R.J. and Smith, N.L. 1975. Quantitative Analysis of Tribromsalan in Blood and Urine. Journal of Pharmaceutical Sciences, Vol. 64, Issue. 12, p. 2007.
    Winkelman, James W. and Grossman, Judith. 1967. Quantitative fluorescence analysis in opaque suspensions using front face optics. Analytical Chemistry, Vol. 39, Issue. 8, p. 1007.
    Gibbs, B. M. and Stuttard, L. W. 1967. Evaluation of Skin Germicides. Journal of Applied Bacteriology, Vol. 30, Issue. 1, p. 66.
    Skelly, Norman E. and Kamke, Kenneth A. 1967. Thin layer chromatography of brominated salicylanilides on diethylaminoethyl cellulose. Analytical Chemistry, Vol. 39, Issue. 8, p. 1009.
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A respirometer technique for estimating germicidal activity on skin

  • R. C. S. Woodroffe (a1)
Extract

1. A technique for measuring the antibacterial activity of germicides on pig skin in micro-respirometers has been described.

2. Using this technique the activity of the following germicides has been estimated: 2,2-dihydroxy, 3,5,6,3′,5′,6′-hexachlorodiphenylmethane, 3,4,4′-trichlorocarbanilide, 3,5,4′tribromosalicylanilide, 2,2′-thiobis (4,6-dichlorophenol), Irgasan CF3*, 3,5,3′,4′-tetrachlorosalicylanilide.

3. The results obtained have been discussed in relation to hand-washing test results (Hurst et al. 1960).

Copyright
COPYRIGHT: © Cambridge University Press 1963
References
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Adams, J. B. (1958). The mode of action of chlorinated bisphenol antibacterials. Part I. Metal chelates of hexachlorophene and thiobisdichlorophenol. J. Pharm., Lond., 10, 507.
Adams, J. B. & Hobbs, M. (1958). The mode of action of chlorinated bisphenol antibacterials. Part II. Biological studies. J. Pharm., Lond., 10, 516.
Bechtold, C. L., Lawrence, E. A. & Owen, E. M. (1955). In vitro test for predicting the effectiveness of antibacterial agents in soap. Proc. Sci. Sect. Toilet Goods Ass. no. 24, 21.
Compeau, G. M. (1960). The adsorption of dodecylbenzenesulfonate and hexachlorophene on skin. J. Amer. pharm. Ass. (Sci. ed.), 49, 574.
Cruickshank, C. N. D. (1954). Continuous observation of the respiration of skin in vitro. Exp. Cell. Res. 7, 374.
Fahlberg, W. J., Swan, J. C. & Seastone, C. V. (1948). Studies on the retention of hexachlorophene (G11) in human skin. J. Bact. 56, 323.
Gould, B. S., Bosniak, M. A., Niedleman, S. & Gatt, S. (1953). Effect of hexachlorophene and related bisphenolic compounds on the dehydrogenases and cytochrome system of Bacillus subtilis and Escherichia coli. Arch. Biochim. Biophys. 44, 284.
Gould, B. S., Frigerio, N. A. & Lebowitz, W. B. (1955). The action of bisphenolic compounds on succinoxidase, cytochrome c oxidase, and lactic dehydrogenase of animal tissue. Arch. Biochim. Biophys. 56, 476.
Hare, R. & Ridley, M. (1958). Further studies on the transmission of Staphylococcus aureus. Brit. med. J. i, 69.
Hare, R. & Thomas, C. G. A. (1956). The transmission of Staphylococcus aureus. Brit. med. J. ii, 240.
Hurley, H. J. & Shelley, W. B. (1960). The Human Apocrine Sweat Gland in Health and Disease, p. 81. Oxford: Blackwell Scientific Publications.
Hurst, A., Stuttard, L. W. & Woodroffe, R. C. S. (1960). Disinfectants for use in bar-soaps. J. Hyg., Camb., 58, 159.
Joswick, H. L. (1961). Mode of action of hexachlorophene. Ph.D. Dissertation, University of Michigan.
Miles, A. A., Williams, R. E. O. & Clayton-Cooper, R. (1944). The carriage of Staphylococcus (pyogenes) aureus in man and its relation to wound infection. J. Path. Bact. 56, 513.
Vinson, L. (1961). In vitro tests for measuring antibacterial activity of toilet soaps and detergent bars. J. Pharm. Sci. 50, 827.
Wilkinson, D. S. (1961). Photodermatitis due to tetrachlorosalicylanilide. Brit. J. Derm. 73, 213.
Williams, R. E. O. (1946). Skin and nose carriage of bacteriophage types of Staphylococcus aureus. J. Path. Bact. 58, 259.
Woodroffe, R. (1963). The measurement of bacterial respiration on pig skin with micro-respirometers. J. Hyg., Camb., 61, 273.
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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
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