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Rotavirus genotypes in children in the Basque Country (North of Spain): rapid and intense emergence of the G12[P8] genotype

  • G. CILLA (a1), M. MONTES (a1), M. GOMARIZ (a1), M. ALKORTA (a2), A. ITURZAETA (a2), E. G. PEREZ-YARZA (a3) (a4) and E. PEREZ-TRALLERO (a1) (a4)
  • DOI:
  • Published online: 03 July 2012

Between July 2009 and June 2011, rotavirus was detected in 507 of 4597 episodes of acute gastroenteritis in children aged <3 years in Gipuzkoa (Basque Country, Spain), of which the G-type was determined in 458 (90·3%). During the annual seasonal epidemic of 2010–2011, the unusual G-type 12 was predominant, causing 65% (145/223) of cases of rotavirus gastroenteritis. All the G12 strains were clustered in lineage III and were preferentially associated with P-type 8. This epidemic was characterized by broad geographical distribution (rural and urban) and, over 7 months, affected both infants and children, the most frequently affected being children between 4 and 24 months. Of children with rotavirus G12, 16% required hospital admission, the admission rate in children aged <2 years being 20·7 cases/10 000 children. The sudden emergence and predominance of G12 rotaviruses documented in this winter outbreak suggest that they may soon become a major human rotavirus genotype.

Corresponding author
*Author for correspondence: Dr G. Cilla, Servicio de Microbiología, Hospital Universitario Donostia, Paseo Dr. Beguiristain s/n, 20014 San Sebastián, Spain. (Email:
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1.JE Tate , ; the WHO-coordinated Global Rotavirus Surveillance Network. 2008 estimate of worldwide rotavirus-associated mortality in children younger than 5 years before the introduction of universal rotavirus vaccination programmes: a systematic review and meta-analysis. Lancet Infectious Diseases 2011; 12: 136141.

3. MMPatel , Real-world impact of rotavirus vaccination. Pediatric Infectious Diseases Journal 2011; 30 (Suppl. 1): S15.

4.N Santos , Y Hoshino . Global distribution of rotavirus serotypes/genotypes and its implication for the development and implementation of an effective rotavirus vaccine. Reviews in Medical Virology 2005; 15: 2956.

5.J Matthijnssens , Uniformity of rotavirus strain nomenclature proposed by the Rotavirus Classification Working Group (RCWG). Archives of Virology 2011; 156: 13971413.

6.M Iturriza-Gómara , B Isherwood , U Desselberger , J Gray . Reassortment in vivo: driving force for diversity of human rotavirus strains isolated in the United Kingdom between 1995 and 1999. Journal of Virology 2001; 75: 36963705.

7.L Maunula , CH Von Bonsdorff . Frequent reassortments may explain the genetic heterogeneity of rotaviruses: analysis of Finnish rotavirus strains. Journal of Virology 2002; 76: 1179311800.

9. ACLinhares , Burden and typing of rotavirus group A in Latin America and the Caribbean: systematic review and meta-analysis. Reviews in Medical Virology. Published online: 7 March 2011. doi:10.1002/rmv.682.

10.M Rahman , Evolutionary history and global spread of the emerging G12 human rotaviruses. Journal of Virology 2007; 81: 23822390.

11.MM Freeman , Phylogenetic analysis of novel G12 rotaviruses in the United States: A molecular search for the origin of a new strain. Journal of Medical Virology 2009; 81: 736746.

12.J Matthijnssens , Phylodynamic analyses of rotavirus genotypes G9 and G12 underscore their potential for swift global spread. Molecular Biology and Evolution 2010; 27: 24312436.

13.M Iturriza Gómara , Molecular characterization of VP6 genes of human rotavirus isolates: correlation of genogroups with subgroups and evidence of independent segregation. Journal of Virology 2002; 76: 65966601.

15.G Cilla , Rotavirus genotypes in children in the Basque Country (northern Spain) over a 13-year period (July 1996-June 2009). European Journal of Clinical Microbiology & Infectious Diseases 2010; 29: 955960.

17.Y Pongsuwanna , Detection of a human rotavirus with G12 and P[9] specificity in Thailand. Journal of Clinical Microbiology 2002; 40: 13901394.

18.DD Griffin , Characterization of nontypeable rotavirus strains from the United States: identification of a new rotavirus reassortant (P2A[6],G12) and rare P3[9] strains related to bovine rotaviruses. Virology 2002; 294: 256269.

19.AA Castello , Molecular epidemiology of group A rotavirus diarrhea among children in Buenos Aires, Argentina, from 1999 to 2003 and emergence of the infrequent genotype G12. Journal of Clinical Microbiology 2006; 44: 20462050.

20.JB Sherchand , Molecular epidemiology of rotavirus diarrhea among children aged <5 years in Nepal: predominance of emergent G12 strains during 2 years. Journal of Infectious Diseases 2009; 200 (Suppl. 1): S182–7.

21.S Sharma , Emergence of G12 rotavirus strains in Delhi, India, in 2000 to 2007. Journal of Clinical Microbiology 2008; 46: 13431348.

22.K Ahmed , Molecular characterization of VP7 gene of human rotaviruses from Bangladesh. Virus Genes 2010; 40: 347356.

23.A de Rougemont , Molecular and clinical characterization of rotavirus from diarrheal infants admitted to pediatric emergency units in France. Pediatric Infectious Diseases Journal 2011; 30: 118124.

24.A Steyer , Rotavirus genotypes in Slovenia: unexpected detection of G8P[8] and G12P[8] genotypes. Journal of Medical Virology 2007; 79: 626632.

25. KBányai , Emergence of serotype G12 rotaviruses, Hungary. Emerging Infectious Diseases 2007; 13: 916919.

26.A Sánchez-Fauquier , Global study of viral diarrhea in hospitalized children in Spain: results of structural surveillance of viral gastroenteritis net work (VIGESS-net) 2006–2008. Journal of Clinical Virology 2011; 52: 353358.

27. PVan Damme , Multicenter prospective study of the burden of rotavirus acute gastroenteritis in Europe, 2004–2005: the REVEAL study. Journal of Infectious Diseases 2007; 195 (Suppl. 1): S416.

28.DC Payne , Secular variation in United States rotavirus disease rates and serotypes: implications for assessing the rotavirus vaccination program. Pediatric Infectious Diseases Journal 2009; 28: 948953.

29. JAStupka , Increased frequency of rotavirus G3P[8] and G12P[8] in Argentina during 2008–2009: Whole-genome characterization of emerging G12P[8] strains. Journal of Clinical Virology. Published online: 14 March 2012; doi:10.1016/j.jcv.2012.02.011.

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