Skip to main content
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 8
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Aguilar-Madrid, Guadalupe Castelán-Vega, Juan Arturo Juárez-Pérez, Cuauhtémoc Arturo Ribas-Aparicio, Rosa María Estrada-García, Iris Baltierra-Jasso, Laura Cervantes-Servín, Nicté Méndez-Ortega, Vanessa Haro-García, Luis C. Sánchez-Román, Francisco Raúl Ortiz-Navarrete, Vianney Fabila-Castillo, Luis H. Magaña-Hernández, Anastasia Chávez-Negrete, Adolfo Salamanca-Gómez, Fabio Abdel and Jiménez-Alberto, Alicia 2015. Seroprevalence of Pandemic A(H1N1) pmd09 Virus Antibodies in Mexican Health Care Workers Before and After Vaccination. Archives of Medical Research, Vol. 46, Issue. 2, p. 154.

    Zhang, Yi Seale, Holly Yang, Peng MacIntyre, Chandini R. Blackwell, Brett Tang, Song and Wang, Quanyi 2013. Factors associated with the transmission of pandemic (H1N1) 2009 among hospital healthcare workers in Beijing, China. Influenza and Other Respiratory Viruses, Vol. 7, Issue. 3, p. 466.

    Glass, Kathryn Kelly, Heath and Mercer, Geoffry Norman 2012. Pandemic Influenza H1N1. Epidemiology, Vol. 23, Issue. 1, p. 86.

    Horby, P. Mai, L. Q. Fox, A. Thai, P. Q. Thi Thu Yen, N. Thanh, L. T. Le Khanh Hang, N. Duong, T. N. Thoang, D. D. Farrar, J. Wolbers, M. and Hien, N. T. 2012. The Epidemiology of Interpandemic and Pandemic Influenza in Vietnam, 2007-2010: The Ha Nam Household Cohort Study I. American Journal of Epidemiology, Vol. 175, Issue. 10, p. 1062.

    Poeppl, W. Poeppl, G. Hunger, M. Tobudic, S. Winkler, H. Faas, A. Mooseder, G. and Burgmann, H. 2012. Pre- and post-pandemic prevalence of antibodies to the 2009 pandemic influenza A (H1N1) virus in Austrian adults. Journal of Medical Virology, Vol. 84, Issue. 9, p. 1331.

    Yang, Peng Zhang, Li Shi, Weixian Lu, Guilan Cui, Shujuan Peng, Xiaomin Zhang, Daitao Liu, Yimeng Liang, Huijie Pang, Xinghuo and Wang, Quanyi 2012. Seroprevalence of pandemic (H1N1) 2009 influenza and effectiveness of 2010/2011 influenza vaccine during 2010/2011 season in Beijing, China. Influenza and Other Respiratory Viruses, Vol. 6, Issue. 6, p. 381.

    Chen, Y. Zheng, Q. Yang, K. Zeng, F. Lau, S.-Y. Wu, W.L. Huang, S. Zhang, J. Chen, H. and Xia, N. 2011. Serological survey of antibodies to influenza A viruses in a group of people without a history of influenza vaccination. Clinical Microbiology and Infection, Vol. 17, Issue. 9, p. 1347.

    Steens, A. Waaijenborg, S. Teunis, P. F. M. Reimerink, J. H. J. Meijer, A. van der Lubben, M. Koopmans, M. van der Sande, M. A. B. Wallinga, J. and van Boven, M. 2011. Age-Dependent Patterns of Infection and Severity Explaining the Low Impact of 2009 Influenza A (H1N1): Evidence From Serial Serologic Surveys in the Netherlands. American Journal of Epidemiology, Vol. 174, Issue. 11, p. 1307.


Serological survey of 2009 H1N1 influenza in residents of Beijing, China

  • Y. DENG (a1), X. H. PANG (a1), P. YANG (a1), W. X. SHI (a1), L. L. TIAN (a1), B. W. LIU (a1), S. LI (a1), S. J. CUI (a1), Y. LI (a1), G. L. LU (a1), L. ZHANG (a1), X. ZHANG (a1), B. LIU (a1), H. SEALE (a2), F. HUANG (a1) and Q. Y. WANG (a1)
  • DOI:
  • Published online: 21 September 2010

In order to determine the prevalence of antibody against 2009 H1N1 influenza in Beijing, we conducted a serological survey in 710 subjects, 1 month after the epidemic peak. We found that 13·8% of our cohort was seropositive. Subjects aged ⩾60 years recorded the lowest seroprevalence (4·5%). The age-weighted seroprevalence of 14·0% was far lower than the supposed infection rate at the epidemic peak, derived from the basic reproduction number for 2009 H1N1 virus. For subjects who had received the pandemic vaccine seroprevalence was 51·4%. In subjects aged ⩾60 years the seasonal influenza vaccination was not significantly associated with being seropositive. Our study suggests that many factors, and not just the immunological level against 2009 H1N1 influenza in the community, affected the spread of the virus within the population of Beijing.

Corresponding author
*Author for correspondence: Dr X. H. Pang, Beijing Center for Disease Prevention and Control (CDC), Capital Medical University School of Public Health and Family Medicine, Beijing 100013, China. (Email:
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

1.R Perez-Padilla , Pneumonia and respiratory failure from swine-origin influenza A (H1N1) in Mexico. New England Journal of Medicine 2009; 361: 680689.

3.C Fraser , Pandemic potential of a strain of influenza A (H1N1): early findings. Science 2009; 324: 15571561.

6.Beijing Health Bureau. A confirmed influenza A (H1N1) case reported in Beijing. 2009 ( Accessed 6 December 2009.

7.P Yang , Review of an influenza surveillance system, Beijing, People's Republic of China. Emerging Infectious Diseases 2009; 15: 16031608.

9.Novel Swine-Origin Influenza A (H1N1) Virus Investigation Team. Emergence of a novel swine-origin influenza A (H1N1) virus in humans. New England Journal of Medicine 2009; 360: 26052615.

10.B Cao , Clinical features of the initial cases of 2009 pandemic influenza A (H1N1) virus infection in China. New England Journal of Medicine 2009; 361: 25072517.

11.S Jain , Hospitalized patients with 2009 H1N1 influenza in the United States, April-June 2009. New England Journal of Medicine 2009; 361: 19351944.

12.S Echevarría-Zuno , Infection and death from influenza A H1N1 virus in Mexico: a retrospective analysis. Lancet 2009; 374: 20722079.

13.ANZIC Influenza Investigators. Critical care services and 2009 H1N1 influenza in Australia and New Zealand. New England Journal of Medicine 2009; 361: 19251934.

15.R Zarychanski , Correlates of severe disease in patients with 2009 pandemic influenza (H1N1) virus infection. Canadian Medical Association Journal 2010; 182: 257264.

16.RR Miller 3rd, Clinical findings and demographic factors associated with intensive care unit admission in Utah due to 2009 novel influenza A (H1N1) infection. Chest 2010; 137: 752758.

17.JK Louie , Severe 2009 H1N1 influenza in pregnant and postpartum women in California. New England Journal of Medicine 2009; 362: 2735.

19.NM Ferguson , Strategies for containing an emerging influenza pandemic in Southeast Asia. Nature 2005; 437: 209214.

20.World Health Organization. Characteristics of the emergent influenza A (H1N1) viruses and recommendations for vaccine development. 2009 ( Accessed 6 December 2009.

21.CW Olsen , Serologic evidence of H1 swine Influenza virus infection in swine farm residents and employees. Emerging Infectious Diseases 2002; 8: 814819.

22.H Chen , Serologic survey of pandemic (H1N1) 2009 virus, Guangxi Province, China. Emerging Infectious Diseases 2009; 15: 18491850.

23.F Carrat , Influenza burden of illness: estimates from a national prospective survey of household contacts in France. Archives of Internal Medicine 2002; 162: 18421848.

24.D Guo , Y Yin . Data Assembly of the Sampling Survey on 1% population in Beijing in 2005. Beijing: China Statistics Press, 2007.

25.E Miller , Incidence of 2009 pandemic influenza A H1N1 infection in England: a cross-sectional serological study. Lancet 2010; 375: 11001108.

26.K Hancock , Cross-reactive antibody responses to the 2009 pandemic H1N1 influenza virus. New England Journal of Medicine 2009; 361: 19451952.

27.MI Chen , 2009 influenza A(H1N1) seroconversion rates and risk factors among distinct adult cohorts in Singapore. Journal of the American Medical Association 2010; 303: 13831391.

28.FC Zhu , A novel influenza A (H1N1) vaccine in various age groups. New England Journal of Medicine 2009; 361: 24142423.

29.XF Liang , Safety and immunogenicity of 2009 pandemic influenza A H1N1 vaccines in China: a multicentre, double-blind, randomised, placebo-controlled trial. Lancet 2010; 375: 5666.

30.ME Greenberg , Response to a monovalent 2009 influenza A (H1N1) vaccine. New England Journal of Medicine 2009; 361: 24052413.

31.Centers for Disease Control and Prevention (CDC). Effectiveness of 2008–09 trivalent influenza vaccine against 2009 pandemic influenza A (H1N1) – United States, May–June 2009. Morbidity and Mortality Weekly Report 2009; 58: 12411245.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
Please enter your name
Please enter a valid email address
Who would you like to send this to? *