Skip to main content Accessibility help
×
×
Home

The Stonehouse survey: nasopharyngeal carriage of meningococci and Neisseria lactamica

  • K. A. V. Cartwright (a1), J. M. Stuart (a2), D. M. Jones (a3) and N. D. Noah (a4)

Summary

A total of 6234 nasopharyngeal swabs was collected during a survey of the population of Stonehouse, Gloucestershire in November 1986 as part of an investigation into an outbreak of meningococcal disease. The overall meningococcal carriage rate was 10·9%. The carriage rate rose with age from 2·1% in the 0- to 4-year-olds to a peak of 24·5% in the 15- to 19-year-olds, and thereafter declined steadily with age. Male carriers outnumbered female carriers of meningococci by 3:2. Group B (or non-groupable) type 15 sulphonamide-resistant strains which had caused the outbreak were isolated from 1·4% of subjects. The age distribution of carriers of these strains was similar to that of other meningococci apart from an additional peak in the 5–9-year age group and a more rapid decline in carriage with increasing age. Variations in the carriage rates of the outbreak strain were seen in children attending different schools and in the residents of different areas of the town. The low carriage rate of these strains in a community during a prolonged outbreak supports the hypothesis that these organisms are less transmissible but more virulent than other strains of pathogenic meningococci.

Carriage of Neisseria lactamica, which is thought to be important in the development of meningococcal immunity, was most frequent in children under the age of 5 years and was six times commoner in this age group than carriage of Neisseria meningitidis. In older children and adults female carriers of N. lactamica increasingly outnumbered males in contrast to the male preponderance observed with meningococcal carriage.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      The Stonehouse survey: nasopharyngeal carriage of meningococci and Neisseria lactamica
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      The Stonehouse survey: nasopharyngeal carriage of meningococci and Neisseria lactamica
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      The Stonehouse survey: nasopharyngeal carriage of meningococci and Neisseria lactamica
      Available formats
      ×

Copyright

References

Hide All
Abbott, J. D., Jones, D. M., Painter, M. J. & Young, S. E. J. (1985). The epidemiology of meningococcal infections in England and Wales 1912–1983. Journal of Infection 11, 241257.
Cann, K. J., Rogers, T. R., Jones, D. M., Noah, N. D. & Burns, C. (1987). Neisseria meningitidis in a primary school. Archives of Disease in Childhood. In press.
Cartwright, K. A. V., Stuart, J. M. & Noah, N. D. (1986). An outbreak of meningococcal disease in Gloucestershire. Lancet ii, 558561.
Fallon, R. J., Brown, W. M. & Lore, W. (1984). Meningococcal infections in Scotland 1972–82. Journal of Hygiene 93, 167180.
Gold, R., Goldschneider, I., Lepow, M. L., Draper, T. F. & Randolph, M. (1978). Carriage of Neisseria meningitidis and Neisseria lactamica in infants and children. The Journal of Infectious Diseases 137, 112121.
Greenwood, B. M. (1984). Meningococcal Infection. In Oxford Textbook of Medicine (ed. Ledingham, Weatherall & Warrell, ). 5. 165174.
Kaiser, A. B., Hennekens, C. H., Saslaw, M. S., Hayes, P. S. & Bennett, J. V. (1974). Seroepidemiology and chemoprophylaxis of disease due to sulphonamide resistant Neisseria meningitidis in a civilian population. The Journal of Infectious Diseases 130, 217224.
Poolman, J. T., Lind, I., Jonsdottir, K., Froholm, L. O., Jones, D. M. & Zanen, H. C. (1986). Meningococcal serotypes and serogroup B disease in north-west Europe. Lancet ii, 555557.
Stuart, J. M., Cartwright, K. A. V., Jones, D. M., Noah, N. D., Wall, R. J., Blackwell, C. C., Jephcott, A. E. & Ferguson, I. R. (1987). An outbreak of meningococcal disease in Stonehouse: planning and execution of a large scale survey. Epidemiology and Infection 99, 579589.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed