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Surveillance of antimicrobial resistance of Salmonella enterica serotype Typhi in seven Asian countries

  • C.-H. CHUANG (a1) (a2), L.-H. SU (a1), J. PERERA (a3), C. CARLOS (a4), B. H. TAN (a5), G. KUMARASINGHE (a5), T. SO (a6), P. H. VAN (a7), A. CHONGTHALEONG (a8), P.-R. HSUEH (a9), J.-W. LIU (a10), J.-H. SONG (a11) and C.-H. CHIU (a1)...

Two hundred and four Salmonella enterica serotype Typhi (S. Typhi) isolates were collected from seven Asian countries during 2002–2004. Multidrug-resistant S. Typhi (resistant to ⩾3 antibiotics) was detected in 84 (41·2%) isolates and 142 (69·6%) showed reduced susceptibility to ciprofloxacin (minimum inhibitory concentration=0·125–1·0 mg/l). This study highlights the worsening situation of antimicrobial resistance of S. Typhi in Asia.

Corresponding author
*Author for correspondence: C.-H. Chiu, M.D., Ph.D., Department of Pediatrics, Chang Gung Children's Hospital, 5 Fu-Hsin Street, Kweishan 333, Taoyuan, Taiwan. (Email:
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1. JH Mermin , Typhoid fever in the United States, 1985–1994: changing risks of international travel and increasing antimicrobial resistance. Archives of Internal Medicine 1998; 158: 633638.

2. SH Mirza , NJ Beeching , CA Hart . Multi-drug resistant typhoid: a global problem. Journal of Medical Microbiology 1996; 44: 317319.

3. CM Parry , Typhoid fever. New England Journal of Medicine 2002; 347: 17701782.

4. J Wain , Quinolone-resistant Salmonella typhi in Vietnam: molecular basis of resistance and clinical response to treatment. Clinical Infectious Diseases 1997; 25: 14041410.

6. MK Bhan , R Bahl , S Bhatnagar . Typhoid and paratyphoid fever. Lancet 2005; 366: 749762.

7. NN Linh , K Arnold . Treatment of typhoid fever and typhoid carriers in Southeast Asia. Viewpoint from South Vietnam. Drugs 1975; 9: 241243.

8. CM Parry . The treatment of multidrug-resistant and nalidixic acid-resistant typhoid fever in Vietnam. Transactions of the Royal Society of Tropical Medicine and Hygiene 2004; 98: 413422.

9. S Sood , Re-emergence of chloramphenicol-sensitive Salmonella typhi. Lancet 1999; 353: 12411242.

11. T Kadhiravan , Clinical outcomes in typhoid fever: adverse impact of infection with nalidixic acid-resistant Salmonella typhi. BMC Infectious Diseases 2005; 5: 37.

12. C Parry , Quinolone-resistant Salmonella typhi in Vietnam. Lancet 1998; 351: 1289.

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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
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