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    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Herath, Verangi C.K. and Carapetis, Jonathan 2015. Sore throat: Is it such a big deal anymore?. Journal of Infection, Vol. 71, p. S101.


    Zheng, Ruo-long Zhang, Hua and Jiang, Wen-long 2014. Tumor necrosis factor-alpha 308G>A polymorphism and risk of rheumatic heart disease: a meta-analysis. Scientific Reports, Vol. 4,


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The dynamic nature of group A streptococcal epidemiology in tropical communities with high rates of rheumatic heart disease

  • M. I. McDONALD (a1) (a2), R. J. TOWERS (a1), R. ANDREWS (a1), N. BENGER (a1), P. FAGAN (a1), B. J. CURRIE (a1) and J. R. CARAPETIS (a1)
  • DOI: http://dx.doi.org/10.1017/S0950268807008655
  • Published online: 01 May 2007
Abstract
SUMMARY

Prospective surveillance was conducted in three remote Aboriginal communities with high rates of rheumatic heart disease in order to investigate the epidemiology of group A β-haemolytic streptococci (GAS). At each household visit, participants were asked about sore throat. Swabs were taken from all throats and any skin sores. GAS isolates were emm sequence and pattern-typed using standard laboratory methods. There were 531 household visits; 43 different emm types and subtypes (emmST) were recovered. Four epidemiological patterns were observed. Multiple emmST were present in the population at any one time and household acquisition rates were high. Household acquisition was most commonly via 5- to 9-year-olds. Following acquisition, there was a 1 in 5 chance of secondary detection in the household. Throat detection of emmST was brief, usually <2 months. The epidemiology of GAS in these remote Aboriginal communities is a highly dynamic process characterized by emmST diversity and turnover.

Copyright
Corresponding author
*Author for correspondence: Dr M. I. McDonald, Menzies School of Health Research, PO Box 41096, Casuarina, 0811, NT, Australia. (Email: malcolm.mcdonald@menzies.edu.au)
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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
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