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The effect of ABO blood groups on the incidence of epidemic influenza and on the response to live attenuated and detergent split influenza virus vaccines

  • J. S. Mackenzie (a1) and P. J. Fimmel (a2)
  • DOI:
  • Published online: 01 May 2009

The effect of blood group status on the incidence of epidemic influenza A (H3N2) infections and on serological response to influenza vaccination with killed subunit and live attenuated vaccines have been investigated during comparative vaccine trials in Western Australia. A significantly higher incidence of epidemic influenza was observed in subjects of blood group B compared with those of other blood groups, regardless of whether they had serological evidence of previous exposure to H3N2 antigens or not. Volunteers of different blood groups exhibited similar seroconversion frequencies to both vaccines after the administration of two doses, but a significantly higher proportion of blood group A subjects seroconverted after receiving their first dose of live attenuated vaccine compared with those of other blood groups. Although this finding was inconsistent with the increased incidence of epidemic influenza in subjects of blood group B, it is discussed in terms of the methods employed to obtain attenuation. Higher geometric mean HI antibody titres were observed in blood group O subjects after the administration of killed subunit vaccine. The results described in this report supported the contention that genetic factors linked to ABO blood groups may play a role in susceptibility to infection with influenza A virus, but that any association must be indirect.

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J. Lindenmann (1964). Inheritance of resistance to influenza virus in mice. Proceedings of the Society for Erperimental Biology and Medicine 116, 506–9.

M. J. Spencer , J. D. Cherry & P. I. Terasaki (1976). HL-A antigens and antibody response after influenza A vaccination. Decreased response associated with HL-A Type W16. New England Journal of Medicine 294, 1316.

G. F. Springer & H. Tritel (1962). Blood group A active substances in embryonated chicken eggs and their relation to egg-grown virus. Science, New York 138, 687–8.

D. A. J. Tyrrell , P. Sparrow & A. S. Beare (1968). Relation between blood groups and resistance to infection with influenza and some picornaviruses. Nature, London 220, 819–20.

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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
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