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    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Eberhardt, Kirsten Alexandra Sarfo, Fred Stephen Dompreh, Albert Kuffour, Edmund Osei Geldmacher, Christof Soltau, Mareike Schachscheider, Marei Drexler, Jan Felix Eis-Hübinger, Anna Maria Häussinger, Dieter Bedu-Addo, George Phillips, Richard Odame Norman, Betty Burchard, Gerd Dieter and Feldt, Torsten 2015. Helicobacter pyloriCoinfection Is Associated With Decreased Markers of Immune Activation in ART-Naive HIV-Positive and in HIV-Negative Individuals in Ghana. Clinical Infectious Diseases, Vol. 61, Issue. 10, p. 1615.


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The immune response to tuberculosis infection in the setting of Helicobacter pylori and helminth infections

  • S. PERRY (a1), A. H. CHANG (a1), L. SANCHEZ (a1), S. YANG (a1), T. D. HAGGERTY (a1) and J. PARSONNET (a1)
  • DOI: http://dx.doi.org/10.1017/S0950268812001823
  • Published online: 07 September 2012
Abstract
SUMMARY

We screened 176 healthy, adult (aged 18–55 years) US refugees from tuberculosis (TB)-endemic countries to evaluate whether cytokine responses to latent TB infection (LTBI) are modified in the setting of concurrent H. pylori and helminth infection. As measured by the Quantiferon-TB GOLD interferon-γ release assay, a total 38 (22%) subjects had LTBI, of which 28 (74%) also were H. pylori seropositive and/or helminth infected. Relative to ten subjects with LTBI only, 16 subjects with concurrent H. pylori infection had significantly elevated levels of IFN-γ, and nine subjects with both H. pylori and helminth infection had significantly elevated levels of IFN-γ, IL-2, IL-13, and IL-5. H. pylori is associated with enhanced IFN-γ responses to TB, even in the setting of concurrent helminth infection. Efficacy of TB vaccines may vary with the co-existence of these three infections in the developing world.

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Corresponding author
*Author for correspondence: S. Perry, Ph.D., Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA, USA. (Email: shnperry@stanford.edu)
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Epidemiology & Infection
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