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    Clarke, Michelle McIntyre, Peter B. Blyth, Christopher C. Wood, Nick Octavia, Sophie Sintchenko, Vitali Giles, Lynne Quinn, Helen Hill, Verity Hanly, Gabrielle Lan, Ruiting and Marshall, Helen S. 2016. The relationship between Bordetella pertussis genotype and clinical severity in Australian children with pertussis. Journal of Infection, Vol. 72, Issue. 2, p. 171.

    Clarke, Michelle Thomas, Natalie Giles, Lynne and Marshall, Helen 2015. Community awareness and predictors of uptake of pertussis booster vaccine in South Australian adults. Vaccine, Vol. 33, Issue. 51, p. 7337.

    Sala-Farré, Maria-Rosa Arias-Varela, César Recasens-Recasens, Assumpta Simó-Sanahuja, Maria Muñoz-Almagro, Carmen and Pérez-Jové, Josefa 2015. Pertussis epidemic despite high levels of vaccination coverage with acellular pertussis vaccine. Enfermedades Infecciosas y Microbiología Clínica, Vol. 33, Issue. 1, p. 27.


The pertussis epidemic: informing strategies for prevention of severe disease

  • M. F. CLARKE (a1) (a2), K. RASIAH (a1), J. COPLAND (a3), M. WATSON (a3), A. P. KOEHLER (a3), K. DOWLING (a4) and H. S. MARSHALL (a1) (a2)
  • DOI:
  • Published online: 17 May 2012

To assess the impact of Bordetella pertussis infections in South Australia during an epidemic and determine vulnerable populations, data from notification reports for pertussis cases occurring between July 2008 and December 2009 were reviewed to determine the distribution of disease according to specific risk factors and examine associations with hospitalizations. Although the majority (66%) of the 6230 notifications for pertussis occurred in adults aged >24 years, the highest notification and hospitalization rate occurred in infants aged <1 year. For these infants, factors associated with hospitalization included being aged <2 months [relative risk (RR) 2·3, 95% confidence interval (CI) 1·60–3·32], Indigenous ethnicity (RR 1·7, 95% CI 1·03–2·83) and receiving fewer than two doses of pertussis vaccine (RR 4·1, 95% CI 1·37–12·11). A combination of strategies aimed at improving direct protection for newborns, vaccination for the elderly, and reducing transmission from close contacts of infants are required for prevention of severe pertussis disease.

Corresponding author
*Author for correspondence: Mrs M. F. Clarke, Discipline of Paediatrics, School of Paediatrics and Reproductive Health, Women's and Children's Hospital, 72 King William Road, North Adelaide, SA 5006, Australia. (Email:
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8.MP Preziosi , E Halloran . Effects of pertussis vaccination on disease: vaccine efficacy in reducing clinical severity. Clinical Infectious Diseases 2003; 37: 772779.

9.P Juretko , Effectiveness of acellular pertussis vaccine assessed by hospital based active surveillance in Germany. Clinical Infectious Diseases 2002; 35: 162167.

11.V Kolos , R Menzies , P McIntyre . Higher pertussis hospitalization rates in indigenous Australian infants, and delayed vaccination. Vaccine 2007; 25: 588590.

12.NM Nielsen , K Hedegaard , P Aaby . Intensity of exposure and severity of whooping cough. Journal of Infection 2001; 43: 1771781.

13.N Wood , P McIntyre , H Marshall , D Roberton . Acellular pertussis vaccine at birth and one month induces antibody responses by two months of age. Pediatric Infectious Diseases Journal 2010; 29: 209215.

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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
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