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The production and preliminary investigation of Burulin, a new skin test reagent for Mycobacterium ulcerans infection

  • J. L. Stanford (a1), W. D. L. Revill (a1), W. J. Gunthorpe (a1) and J. M. Grange (a1)
  • DOI:
  • Published online: 01 May 2009

The preparation of a skin test antigen from Mycobacterium ulcerans by ultrasonic disintegration and filtration is described. The reagent, called Burulin, was tested in Africa in normal school children, and in patients with leprosy, tuberculosis or M. ulcerans disease. Those with tuberculosis or M. ulcerans disease were simultaneously tested with Tuberculin PPD. Burulin was found to be highly specific for patients in the reactive stage of M. ulcerans disease, and there was no cross-reaction in patients with other mycobacterioses. On the other hand, the majority of patients with M. ulcerans disease reacting to Burulin also produce positive reactions to Tuberculin PPD.

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D. J. P. Barker (1972). Epidemiology of Mycobacterium ulcerans infection. Transactions of the Royal Society of Tropical Medicine and Hygiene 67, 4350.

S. Mudd (1925). A study by new methods of the surfaces of normal and sensitized acid fast bacteria. Proceedings of the Society for Experimental Biology and Medicine 23, 569–72.

J. L. Stanford (1973). An immunodiffusion analysis of strains of Mycobacterium ulcerans isolated in Australia, Malaya, Mexico, Uganda and Zaire. Journal of Medical Microbiology 6, 405–8.

Uganda Buruli Group (1971). Epidemiology of Mycobacterium ulcerans infection (Buruli ulcer) at Kinyara, Uganda. Transactions of the Royal Society of Tropical Medicine and Hygiene 65, 763–75.

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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
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