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The Toxicology of Nickel Carbonyl

  • H. W. Armit (a1)
Extract

1. Nickel carbonyl is a highly toxic compound.

2. Dissociation of nickel carbonyl takes place rapidly at the temperature of the body in the presence of air, moisture and carbon dioxide.

Nickel carbonyl also dissociates at the temperature of the body in the absence of air, moisture and carbon dioxide, but not to the same extent as in the presence of these owing to the fact that a reversible action occurs between the nickel and the dissociated carbon monoxide.

3. Nickel carbonyl is soluble in water to the amount of 2·36 c.cm. of vapour (i.e. 6·43 mgrs. of nickel) per 100 grs. at 9·8° C.

The amount dissolved in water is directly proportional to the pressure, when the temperature is constant.

The solubility in water diminishes as the temperature is raised.

4. The solubility of nickel carbonyl in serum and in blood is about 2½ times greater than that in water. At 10° C. 100 grs. of serum dissolves 5·98 c.cm. of nickel carbonyl vapour (i.e. 15·71 mgrs. of nickel).

5. When nickel carbonyl is brought into contact with water, serum, blood and other liquids, if oxygen and carbon dioxide are present, dissociation occurs and a substance is formed, probably a hydrated basic carbonate of nickel, which is slightly soluble, but also forms a very fine precipitate, which renders the liquid turbid. The liquid can only be cleared of the turbidity by passing it through a Berkefeld filter.

6. Water dissolves about 0·0035% of the product of dissociated nickel carbonyl (reckoned as nickel) at 18° C. About the same amount is dissolved in 10% solutions of sodium carbonate.

The solubility of this product of dissociated nickel carbonyl is greater in serum than in water. Serum dissolves about 0·0183% (reckoned as nickel). A solution of the salts of serum, under the same conditions, dissolves 0·005% (reckoned as nickel). Solutions of sodium phosphate of approximately the same strength as the phosphates in serum, dissolve 0·0025% (reckoned as nickel).

7. Nickel hydrate is insoluble in water but is soluble in serum to the extent of 0·0225 gr. nickel per 100 grs. serum, and in sodium phosphate solutions to the extent of 0·012% (reckoned as nickel).

8. Nickel carbonate is soluble in water to the extent of 0·0005% (reckoned as nickel), and in serum to an amount, corresponding to 0·016 gr.% of nickel. Salts of serum dissolve 0·0045 gr. % of nickel carbonate reckoned as nickel. Nickel carbonate is insoluble in sodium phosphate solutions.

9. Dissociation product in aqueous solution is precipitated by boiling, and to a certain extent by the addition of electrolytes. Some of it is thrown out of solution spontaneously on standing for some days, whereas solutions of nickel carbonate are not precipitated by either of the above means.

10. Solutions of dissociation product dialyse more slowly than solutions of similar strength of nickel carbonate, and at a certain stage in the dialysis the greater part of the nickel is adsorbed into the membrane.

11. No constant ratio exists between the nickel and the nitrogen contents of solutions of dissociation product in serum of different strengths.

12. When the proteids of the serum, containing the product of dissociated nickel carbonyl in solution, are precipitated by ammonium sulphate, nine-tenths of the nickel remains in solution. One-tenth is precipitated by adding sufficient ammonium sulphate to produce one-third of saturation, and about an additional one-hundredth by producing one-half of saturation.

13. The product of dissociated nickel carbonyl when dissolved in serum is only incompletely removable from solution by dialysis.

The product of dissociated nickel carbonyl is therefore not identical with nickel carbonate or nickel hydrate, and appears to exist in a condition of colloidal solution.

14. The poisonous properties of nickel carbonyl do not depend, as was at first supposed, on the carbon monoxide of the compound.

15. Nickel carbonyl when mixed with air and inhaled by an animal, cannot be absorbed as such, as it becomes split up into the nickel containing substance (? hydrated basic carbonate of nickel) and carbon monoxide, before or soon after reaching the alveoli of the lungs.

16. The poisonous effects of nickel carbonyl are entirely due to the nickel of the compound. The peculiar toxicity of the compound is due to the fact that being introduced in a gaseous form and that the nickel is deposited as a slightly soluble compound in a very fine state of subdivision over the immense area of the respiratory surface.

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References
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Apt, (1898), Ueber die elektrische und magnetische Eigenschaften des Nickeltetrakarbonyls. Schrift. des naturw. Vereins f. Schleswig-Holstein, vol. II. Part II.
Berthelot, (1891), Sur une combinaison volatile de fer et d'oxyde de carbone, le fer carbonyle, et sur le nickel carbonyle. Comptes rend., vol. CXII. p. 1343.
Berthelot, Sur l'oxydation du nickel carbonyle. Comptes rend., vol. CXII. p. 679.
Berthelot, Essais divers avec les métaux et l'oxyde de carbone. Ann. chim. Phys. vol. XXII. p. 304.
Dewar, and Jones, (1903), On some physical properties of nickel carbonyl. Trans. Roy. Soc. vol. LXXI. p. 427.
Dewar, and Jones, (1905), The physical and chemical properties of Iron Carbonyl. Roy. Soc. Pros. A. 1905, vol. LXXVI. p. 558.
Dewar, and Jones, (1906), On a new Iron Carbonyl, and on the action of light and of heat on the Iron Carbonyls. Roy. Soc. Pros. A. 1906, vol. LXXIX. p. 66.
Frey, H. (1896), Eine neue Bindungsweise von Nickelkohlenoxyd. Ber. d. deutsch. chem. Gesellsch. vol. XXVIII. (3) p. 2512.
Gladstone, J. H. (1893), Notes on some recent determinations of molecular refraction and dispersion. Philosoph. Mag., vol. XXXV. p. 204.
Mittasch, A. (1902), Ueber die chemische Dynamik des Nickelkohlenoxyd. Zeitschrift f. phys. Chemie, vol. XL. p. 1.
Mond, L. (1891), On Nickel Carbon Oxide and its application in arts and manufacture. Chem. News, vol. LXIV. p. 108.
Mond, L., Langer, C. and Quincke, F. (1890), The action of Carbon Monoxide on Nickel. Journal Chem. Soc., vol. LVII. p. 749.
Mond, L. and Nasini, R. (1891), Ueber einige physikalische Eigenschaften des Nickeltetrakarbonyls und andrer Nickelverbindungen. Zeitschr. f. phys. Chemie, vol. VIII. p. 150.
Mond, L. and Nasini, R.Studi sul Nichel tetracarbonile. Atti d. Rend. Accad. Lincei, vol. VII. p. 411.
Nasini, R. and Anderlini, (1894), Sul potere rifrangente dei composti contenenti il carbonile. Atti d. Rend. Accad. Lincei, vol. III. (1st Semester) p. 49.
Nasini, R. and Anderlini, Sul potere rifrangente dei composti contenenti il carbonile. Gazz. chim. ital. vol. XXIV. (1) p. 157.
Reicher, (1896), De verbrandingswarmte van Nikkelkooloxyde. Werk. v. h. Genootschap t. bevoord. d. natuur-, genees- en heelkunde, 2nd Series, Deel 2, p. 296.
Reicher, and Jorissen, (1894). Maandblad voor natuurwetenschappen, No. 1.
Wartha, (1892), Zur Kenntniss der Metall-kohlenoxyd-verbindungen. Chem. Zeit., vol. XV. p. 915.
Henriot, et Richet (1891), Des effets physiologiques et toxiques du nickel carbonyle. Comptes rend. d. l. Soc. Biolog., vol. III. (Series 9) p. 185.
Langlois, P. (1891), Action du Nickel Carbonyl sur les gaz du sang. Comptes rend. d. l. Soc. Biol., vol. III. (Series 9) p. 212.
McKendrick, and Snodgrass, (1891), On the physiological action of Carbon monoxide of Nickel. Brit. Med. Journ. vol. I. p. 1215.
Vahlen, E. (1902), Ueber das Verhalten des Kohlenoxydnickels im Thierkörper. Arch. f. exper. Pathol. u. Pharmak., vol. XLVIII. p. 117.
Brodie, (1859), On the combination of Carbonic Oxide with Potassium. Journ. Chem. Soc. vol. XII. p. 269.
Liebig, Justus (1834), Ueber das Verhalten des Kohlenoxyd zu Kalium. Ann. d. chem. Pharm., vol. XI. p. 182.
Grehant, (1888), Sur les accidents avec l'oxyde de carbone. Comptes rend., vol. CVI. p. 289.
Grehant, (1891), Loi de l'absorption de l'oxyde de carbone par le sang d'un mammifère vivant. Comptes rend., vol. CXIV. p. 6.
Gruber, Max (1883), Ueber den Nachweis und die Giftigkeit des Kohlenoxyds und sein Vorkommen in Wohnräume. Arch. f. Hygiene, vol. I. p. 145.
Haldane, J. (1895), The action of Carbonic Oxide in man. Journ. Phys., vol. XVIII. Nos. 5 and 6, p. 430.
Haldane, J.A method of detecting and estimating Carbonic Oxide in Air. Journ. Phys., vol. XVIII. Nos 5 and 6, p. 463.
Kunkel, A. J. (1899), Handbuch der Toxicologie. Jena (G. Fischer).
Sachs, W. (1900), Die Kohlenoxyd-Vergiftung. Braunschweig (F. Vieweg und Sohn).
Anderson, Stuart (1884), Ueber die Einfluss der Nickel- und Kobaltverbindungen auf den thierischen Organismus. Arch. f. exp. Pathol. u. Pharmak., vol. XVIII. p. 151. (Also Journal of Physiology, vol. XVIII. p. 89.) (Literature.)
Birnbaum, (1883), Ueber die Widerstandskraft von Gefässen aus nickelplattiertem Eisenbleche, gegen organische Säure. Dingler's polyt. Journ., vols. CCXLVIII. and CCXLIX. pp. 421 and 515.
Chittenden, and Norris, (1889), The relative absorption of Nickel and Cobalt. Studies of the Phys. Laboratories, Yale Univers., vol. III. p. 148.
Coppola, (1885), Sull’ azione fisiologica del nichel e’ del cobalto. Lo Sperimentale, April. Sull’ azione fisiologica del nichel e' del cobalto. Ann. di chim. e di farm. (4th Series), vol. IV. p. 123.
Laborde, and Riche, (1888), Action du sulfate de nickel sur l'orgauisme. Comptes rend. d. l. Soc. Biolog., vol. xl. p. 681.
Laborde, and Riche, Action physiologique de sulfate de nickel. Journ. d. Pharm. et d. Chimie, vol. XVII. p. 59.
Pitini, and Messina, (1899), Ueber die blutbildende Kraft des Nickels und des Kobalts. Arch. di Farm. e Terap. vol. VII. p. 1. (Abst. in Maly, vol. XXXII. p. 229, only available.)
Riche, A. (1888), Sur l'action des sels de nickel sur l'organisme. Journ. de Pharm. et de Chimie, vol. XVII. p. 5.
Rohde, (1889), Ueber die Angreifbarkeit der Nickelverbindungen durch organische Säuren. Arch. f. Hygiene, vol. IX. p. 331.
Roos, (1887), Versuche über die physiologischen Wirkungen des Nickelacetats mit Rücksicht auf den Gebrauch dieses Metalles für Kochgeräthe. Chem. Centralb., p. 1360.
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