Skip to main content
×
Home
    • Aa
    • Aa

Trends in antimicrobial resistance phenotypes in non-typhoid Salmonellae from human and poultry origins in France

  • J. CAILHOL (a1), R. LAILLER (a2), P. BOUVET (a3), S. LA VIEILLE (a1), F. GAUCHARD (a1), P. SANDERS (a4) and A. BRISABOIS (a2)...
Summary
SUMMARY

A total of 1873 strains from human origin and 4283 strains from non-human origin of Salmonella enterica serotypes Typhimurium, Enteritidis, Heidelberg, Hadar and Virchow, collected over three years 1993, 1997 and 2000, were examined in order to determine the rate of antimicrobial resistance to 12 antimicrobial drugs. The objective of the study was to describe and to compare the evolution of the main resistance types in human and non-human isolates, focusing on the poultry sector. The evolution and the rates of antimicrobial resistances for the five serotypes, with the exception of Virchow, were almost comparable in strains isolated from human and non-human sources over the period studied. The most striking result concerning single resistance was the spectacular increase of the resistance frequency to nalidixic acid for the strains belonging to serotypes Hadar and Virchow, especially in the poultry food sector (14% in 1993 vs. 72% in 2000 for Salmonella Virchow, 4% in 1993 vs. 70% in 2000 for Salmonella Hadar) and also in human isolates (24% in 1997 vs. 48% in 2000 for S. Virchow, 31% in 1997 vs. 78% in 2000 for S. Hadar). In addition to the classical resistance to ampicillin, streptomycin, sulphonamide, chloramphenicol and tetracycline (ASSuCT resistance type), which stabilized between 1997 and 2000, the emergence of a new resistance type was observed.

Copyright
Corresponding author
*Author for correspondence: Dr A. Brisabois, AFSSA Lerqap, Maisons-Alfort, France. (Email: a.brisabois@afssa.fr)
References
Hide All
1.Haeghebaert S, Le Querrec F, Gallay A, Bouvet P, Gomez M, Vaillant V. Foodborne diseases in France in 1999 and 2000. In: Surveillance nationale des maladies infectieuses, 1998–2000. Institut de Veille Sanitaire, Saint-Maurice, France. November 2002: 161169.
2.Cloeckaert A, Schwarz S. Molecular characterization, spread and evolution of multidrug resistance in Salmonella enterica typhimurium DT104. Vet Res 2001; 32: 301310.
3.Threlfall EJ. Epidemic salmonella typhimurium DT 104 – a truly international multiresistant clone. J Antimicrob Chemother 2000; 46: 710.
4.Breuil J, Brisabois A, Casin I, Armand-Lefevre L, Fremy S, Collatz E. Antibiotic resistance in salmonellae isolated from humans and animals in France: comparative data from 1994 and 1997. J Antimicrob Chemother 2000; 46: 965971.
5.Cruchaga S, Echeita A, Aladuena A, Garcia-Pena J, Frias N, Usera MA. Antimicrobial resistance in salmonellae from humans, food and animals in Spain in 1998. J Antimicrob Chemother 2001; 47: 315321.
6.Leegaard TM, Caugnat DA, Froholm LO, Hoiby EA, Lassen J. Emerging antibiotic resistance in Salmonella typhimurium in Norway. Epidemiol Infect 2000; 125: 473480.
7.Murphy TM, McNamara E, Hill M, et al. Epidemiological studies of human and animal Salmonella typhimurium DT104 and DT104b isolates in Ireland. Epidemiol Infect 2001; 126: 39.
8.Hart CA, Kariuki S. Antimicrobial resistance in developing countries. BMJ 1998; 317: 647650.
9.Hakanen A, Siitonen A, Kotilainen P, Huovinen P. Increasing fluoroquinolone resistance in Salmonella serotypes in Finland during 1995–1997. J Antimicrob Chemother 1999; 43: 145148.
10.Threlfall EJ, Ward LR, Rowe B. Resistance to ciprofloxacin in non-typhoidal salmonellas from humans in England and Wales – the current situation. Clin Microbiol Infect 1999; 5: 130134.
11.Aarestrup FM. Association between the consumption of antimicrobial agents in animal husbandry and the occurrence of resistant bacteria among food animals. Int J Antimicrob Agents 1999; 12: 279285.
12.McEwen SA, Fedorka-Cray PJ. Antimicrobial use and resistance in animals. Clin Infect Dis 2002; 34 (Suppl 3): S93S106.
13.van den Bogaard AE, Stobberingh EE. Epidemiology of resistance to antibiotics. Links between animals and humans. Int J Antimicrob Agents 2000; 14: 327335.
14.Barza M, Travers K. Excess infections due to antimicrobial resistance: the ‘Attributable Fraction’. Clin Infect Dis 2002; 34 (Suppl 3): S126S130.
15.Travers K, Barza M. Morbidity of infections caused by antimicrobial-resistant bacteria. Clin Infect Dis 2002; 34 (Suppl 3): S131S134.
16.Caprioli A, Busani L, Martel JL, Helmuth R. Monitoring of antibiotic resistance in bacteria of animal origin: epidemiological and microbiological methodologies. Int J Antimicrob Agents 2000; 14: 295301.
17.Fuchs PC, Barry AL, Pfaller MA, Hardy DJ, McLaughlin JC, Gerlach EH. In vitro activity of ampicillin, amoxicillin, ampicillin-sulbactam, and amoxicillin-clavulanic acid against consecutive clinical isolates of Enterobacteriaceae. Diagn Microbiol Infect Dis 1993; 17: 171175.
18.Franklin A, Acar J, Anthony F, et al. Antimicrobial resistance: harmonisation of national antimicrobial resistance monitoring and surveillance programmes in animals and in animal-derived food. Rev Sci Tech 2001; 20: 859870.
19.Bager F, Helmuth R. Epidemiology of resistance to quinolones in Salmonella. Vet Res 2001; 32: 285290.
20.Davies RH, Teale CJ, Wray C, et al. Nalidixic acid resistance in salmonellae isolated from turkeys and other livestock in Great Britain. Vet Rec 1999; 144: 320322.
21.Fey PD, Safranek TJ, Rupp ME, et al. Ceftriaxone-resistant salmonella infection acquired by a child from cattle. N Engl J Med 2000; 342: 12421249.
22.Poppe C, Smart N, Khakhria R, Johnson W, Spika J, Prescott J. Salmonella typhimurium DT104: a virulent and drug-resistant pathogen. Can Vet J 1998; 39: 559565.
23.Rabsch W, Tschape H, Baumler AJ. Non-typhoidal salmonellosis: emerging problems. Microbes Infect 2001; 3: 237247.
24.White DG, Zhao S, Sudler R, et al. The isolation of antibiotic-resistant salmonella from retail ground meats. N Engl J Med 2001; 345: 11471154.
25.Martel JL, Tardy F, Brisabois A, Lailler R, Coudert M, Chaslus-Dancla E. The French antibiotic resistance monitoring programs. Int J Antimicrob Agents 2000; 14: 275283.
26.Martel JL, Tardy F, Sanders P, Boisseau J. New trends in regulatory rules and surveillance of antimicrobial resistance in bacteria of animal origin. Vet Res 2001; 32: 381392.
27.Cloeckaert A, Sidi Boumedine K, Flaujac G, Imberechts H, D'Hooghe I, Chaslus Dancla E. Occurrence of a Salmonella enterica serotype Typhimurium DT104-like antibiotic resistance gene cluster including the floR gene in S. enterica serotype Agona. Antimicrob Agents Chemother 2000; 44: 13591361.
28.Cloeckaert A, Chaslus-Dancla E. Mechanisms of quinolone resistance in Salmonella. Vet Res 2001; 32: 291300.
29.Johnston AM. Use of antimicrobial drugs in veterinary practice. BMJ 1998; 317: 665667.
30.Threlfall EJ, Skinner JA, Graham A, Ward LR, Smith HR. Resistance to ceftriaxone and cefotaxime in non-typhoidal Salmonella enterica in England and Wales, 1998–99. J Antimicrob Chemother 2000; 46: 860862.
31.Walker RA, Lawson AJ, Lindsay EA, et al. Decreased susceptibility to ciprofloxacin in outbreak-associated multiresistant Salmonella typhimurium DT104. Vet Rec 2000; 147: 395396.
32.Hakanen A, Kotilainen P, Jalava J, Siitonen A, Huovinen P. Detection of decreased fluoroquinolone susceptibility in Salmonellas and validation of nalidixic acid screening test. J Clin Microbiol 1999; 37: 35723577.
33.Threlfall EJ, Ward LR, Skinner JA, Graham A. Antimicrobial drug resistance in non-typhoidal salmonellas from humans in England and Wales in 1999: decrease in multiple resistance in Salmonella enterica serotypes Typhimurium, Virchow, and Hadar. Microb Drug Resist 2000; 6: 319325.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Metrics

Full text views

Total number of HTML views: 1
Total number of PDF views: 4 *
Loading metrics...

Abstract views

Total abstract views: 94 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 21st October 2017. This data will be updated every 24 hours.