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Understanding the impact of Hib conjugate vaccine on transmission, immunity and disease in the United Kingdom

  • J. McVERNON (a1) (a2) (a3), M. E. RAMSAY (a2) and A. R. McLEAN (a1)
  • DOI: http://dx.doi.org/10.1017/S0950268807009168
  • Published online: 03 August 2007
Abstract
SUMMARY

A rise in invasive Haemophilus influenzae type b (Hib) infections occurred 8 years after vaccine introduction in the United Kingdom. Aspects of Hib vaccine delivery unique to the United Kingdom have been implicated. The authors developed a fully age-structured deterministic susceptible–infected–resistant–susceptible mathematical model, expressed as a set of partial differential equations, to better understand the causes of declining vaccine effectiveness. We also investigated the consequences of the vaccine's impact on reducing Hib transmission for maintenance of immunity. Our findings emphasized the importance of maintaining high post-immunization antibody titres among age groups at greatest risk of invasive infections. In keeping with UK population-based estimates, low direct efficacy of immunological memory against disease was found, cautioning against over-reliance on evidence of priming alone as a correlate of population protection. The contribution of herd immunity to disease control was reinforced. Possible intervention strategies will be explored in subsequent work.

Copyright
Corresponding author
*Author for correspondence: Dr J. McVernon, Vaccine and Immunisation Research Group, Murdoch Childrens Research Institute & School of Population Health, University of Melbourne, Level 5, 207 Bouverie Street, Carlton, Victoria, 3053, Australia. (Email: mcvernon@unimelb.edu.au)
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2. P Heath , Antibody concentration and clinical protection after Hib conjugate vacination in the United Kingdom. Journal of the American Medical Association 2000; 284: 23342340.

3. J McVernon , Risk of vaccine failure after Haemophilus influenzae type b (Hib) combination vaccines with acellular pertussis. Lancet 2003; 361: 15211523.

5. P Heath , M Ramsay . Haemophilus influenzae type b vaccine – booster campaign. British Medical Journal 2003; 326: 11581159.

6. M Ramsay , Estimating Haemophilus influenzae type b vaccine effectiveness in England and Wales by use of the screening method. Journal of Infectious Diseases 2003; 188: 481485.

7. CL Trotter , Antibody to Haemophilus influenzae type b after routine and catch-up vaccination. Lancet 2003; 361: 15231524.

8. T Murphy , Decreased Haemophilus colonization in children vaccinated with Haemophilus influenzae type b conjugate vaccine. J Pediatrics 1993; 122: 517523.

9. M Barbour , The impact of conjugate vaccine on carriage of Haemophilus influenzae type b. Journal of Infectious Diseases 1995; 171: 9398.

10. A Takala , Reduction of oropharyngeal carriage of Haemophilus influenzae type b (Hib) in children immunized with an Hib conjugate vaccine. Journal of Infectious Diseases 1991; 164: 982986.

11. J Mohle-Boetani , Carrige of Haemophilus influenzae type b in children after widespread vaccination with conjugate Haemophilus influenzae type b vaccines. Pediatric Infectious Disease Journal 1993; 12: 589593.

13. R Michaels , C Norden . Pharyngeal colonization with Haemophilus influenzae type b: a longitudinal study of families with a child with meningitis or epiglottitis due to H influenzae type b. Journal of Infectious Diseases 1977; 136: 222228.

16. P Anderson , Antibody to polyribophosphate of Haemophilus influenzae type b in infants and children: effect of imunization with polyribophosphate. Journal of Infectious Diseases 1977; 136 (Suppl.): S57S62.

17. H Kayhty , The protective level of serum antibodies to the capsular polysaccharide of Haemophilus influenzae type b. Journal of Infectious Diseases 1983; 147:1100.

18. M Halloran , Population biology, evolution, and immunology of vaccination and vaccination programs. American Journal of Medical Science 1998; 315: 7686.

22. M Kauppi-Korkeila , Mechanism of antibody-mediated reduction of nasopharyngeal colonization by Haemophilus influenzae type b studied in an infant rat model. Journal of Infectious Diseases 1996; 174: 13371340.

23. J Fernandez , Prevention of Haemophilus influenzae type b colonization by vaccination: correlation with serum anti-capsular IgG concentration. Journal of Infectious Diseases 2000; 182: 15531556.

24. D Goldblatt , Immunological response to conjugate vaccines in infants: a follow up study. British Medical Journal 1998; 316: 15701571.

25. RM Anderson , R May . Infectious Disease of Humans: Oxford University Press, 1991.

26. T Murphy , Pharyngeal colonization with Haemophilus influenzae type b in children in a day care center without invasive disease. Journal of Paediatrics 1985; 106: 712716.

28. P Makela , Polysaccharide vaccines of Group A Neisseria meningitidis and Haemophilus influenzae type b: a field trial in Finland. Journal of Infectious Diseases 1977; 136 (Suppl): S43S50.

29. J Robbins , Prevention of systemic infectrions, especially meningitis, caused by Haemophilus influenzae type b. Journal of the American Medical Association 1996; 276: 11811185.

33. M Barbour , Haemophilus influenzae type b carriage and immunity four years after receiving the Haemophilus influenzae oligosaccharide-CRM 197 (HbOC) conjugate vaccine. Pediatric Infectious Disease Journal 1993; 12: 478484.

34. D Goldblatt , Antibody avidity as a surrogate marker of successful priming by Haemophilus influenzae type b conjugate vaccines following infant immunization. Journal of Infectious Diseases 1998; 177: 11121115.

35. D Scheifele , Extended follow-up of antibody levels and antigen responsiveness after 2 Haemophilus influenzae type b conjugate vaccines. Journal of Paediatrics 1999; 135: 240245.

36. P Makela , Long-term persistence of immunity after immunisation with Haemophilus influenzae type b conjugate vaccine. Vaccine 2003; 22: 287292.

37. F Bell , Effect of combination with an acellular pertussis, diphtheria, tetanus vaccine on antibody response to Hib vaccine (PRP-T). Vaccine 1998; 16: 637642.

39. J Eskola , Combined vaccination of Haemophilus influenzae type b conjugate and diphtheria-tetanus-pertussis containing acellular pertussis. Lancet 1999; 354: 20632068.

40. J Poolman , Clinical relevance of lower Hib response in DTPa-based combination vaccines. Vaccine 2001; 19: 22802285.

41. R Singleton , Experience with the prevention of invasive Haemophilus influenzae type b disease by vaccination in Alaska: the impact of persistent oropharyngeal carriage. Journal of Paediatrics 2000; 137: 313320.

42. A Smith . Pathogenesis of Haemophilus influenzae meningitis. Pediatric Infectious Disease Journal 1987; 6: 783786.

43. P Coen , Mathematical models of Haemophilus influenzae type b. Epidemiology and Infection 1998; 120: 281295.

44. A Rushdy , Infant Hib vaccination and herd immunity. Journal of Paediatrics 1999; 134: 253254.

45. J McVernon , Trends in Haemophilus influenzae type b infections in adults in England and Wales: surveillance study. British Medical Journal 2004; 329: 655658.

48. C Ounsted . Ecology of Haemophilus influenzae meningitis. Lancet 1951; 257: 800801.

49. C Trotter , N Gay , W Edmunds . Dynamic models of meningococcal carriage, disease and the impact of serogroup C conjugate vaccination. American Journal of Epidemiology 2005; 162: 89100.

51. J Robbins , Quantitative measurement of ‘natural’ and immunization-induced Haemophilus influenzae type b capsular polysaccharide antibodies. Pediatric Research 1973; 7: 103110.

52. P Coen , P Heath , G Garnett . The Hib immunization programme in the Oxford region: an analysis of the impact of vaccine administration on the incidence of disease. Epidemiology and Infection 1999; 123: 389402.

54. B Bolker , B Grenfell . Impact of vaccination on the spatial correlation and persistence of measles dynamics. Proceedings of the National Academy of Sciences 1996; 93: 1264812653.

56. M Glode , Epiglottitis in adults: association with Haemophilus influenzae type b colonization and disease in children. Pediatric Infectious Diseases Journal 1984; 3: 548551.

57. C Trotter , Effectiveness of meningococcal serogroup C conjugate vaccine 4 years after introduction. Lancet 2004; 364: 365367.

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