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Cholesterol concentrations in violent and non-violent women suicide attempters

Published online by Cambridge University Press:  16 April 2020

J. Vevera ,
I. Žukov ,
T. Morcinek  and
H. Papežová
J. Vevera*
Affiliation:
Psychiatric Clinic, 1st Medical Faculty, Charles University of Prague, Prague, Czech Republic School of Public Health, University of California at Berkeley, 140 Warren Hall, MC7360, Berkeley, CA 94720, USA
I. Žukov
Affiliation:
Psychiatric Clinic, 1st Medical Faculty, Charles University of Prague, Prague, Czech Republic
T. Morcinek
Affiliation:
Psychiatric Hospital in Bohnice, Prague, Czech Republic
H. Papežová
Affiliation:
Psychiatric Clinic, 1st Medical Faculty, Charles University of Prague, Prague, Czech Republic
*
*E-mail address: j_vevera@hotmail.com
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Abstract

The aim of this study was to evaluate whether women with a history of violent suicide attempts have lower serum cholesterol concentrations than those who attempted suicide by non-violent methods. Our retrospective study used a case-control design to compare serum total cholesterol concentration, hematocrit, red blood cell count and body mass index (BMI) in women with a history of violent (n = 19) or non-violent (n = 51) suicide attempts and of non-suicidal controls (n = 70) matched by diagnosis and age. Analysis of covariance (ANCOVA) with age as the covariate was used to analyze differences in cholesterol levels in groups according to violence. Violence was found to be a significant factor (P = 0.016). Using the Scheffé test, a significant difference (P = 0.011) was revealed between the group of violent and non-violent suicide attempters and between the violent suicide attempters and the control group. Patients with a violent suicidal attempt have significantly lower cholesterol levels than patients with non-violent attempts and the control subjects. Our findings suggest that suicide attempts should not be considered a homogenous group. They are consistent with the theory that low levels of cholesterol are associated with increased tendency for impulsive behavior and aggression and contribute to a more violent pattern of suicidal behavior.

Keywords

CholesterolSuicideViolenceImpulsivity
Type
Original article
Information
European Psychiatry , Volume 18 , Issue 1 , February 2003 , pp. 23 - 27
Copyright
Copyright © Éditions scientifiques et médicales Elsevier SAS 2003

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References

Agargun, MY, Sekeroglu, MR, Kara, H, Ozer, OA, Tombul, T, Kiran, Uet al. Sleep-related violence and low serum cholesterol: a preliminary study. Psychiatry Clin Neurosci 2002;56:195–8.CrossRefGoogle ScholarPubMed
Alwarez, JC, Cremniter, D, Lesieur, P, Gregoire, A, Gilton, A, Mavquin-Mavier, Iet al. Low blood cholesterol and low platelet serotonin levels in violent suicide attempters. Biol Psychiatry 1999;45:1066–9.CrossRefGoogle Scholar
Alvarez, JC, Cremniter, D, Gluck, N, Quintin, P, Leboyer, M, Berlin, Iet al. Spreux-Varoquaux O: low serum cholesterol in violent but not in non-violent suicide attempters. Psychiatry Res 2000;2:103–8.CrossRefGoogle Scholar
Apter, A, Laufer, N, Bar-Sever, M, Har-Even, D, Ofek, H, Weizman, ASerum cholesterol, suicidal tendencies, impulsivity, aggression and depression in adolescent psychiatric inpatients. Biol psychiatry 1999;46:532–41.CrossRefGoogle ScholarPubMed
Balon, RCholesterol, mental illness and violence. Psychiatrie 2000;2:83–90.Google Scholar
Boyd, JH. The increasing rate of suicide by firearms. N Engl J Med 1983;308:872–4.CrossRefGoogle ScholarPubMed
Brown, GL, Linnoila, MICSF serotonin metabolite (5-HIAA) studies in depression, impulsivity and violence. J Clin Psychiatry 1990;51:31–41.Google ScholarPubMed
Engelberg, HLow serum cholesterol and suicide. Lancet 1992;339:727–9.CrossRefGoogle ScholarPubMed
Gimpl, G, Burger, K, Fahrenholz, FCholesterol as modulator of receptor function. Biochemistry 1997;36:10959–74.CrossRefGoogle ScholarPubMed
Golier, J, Marzuk, P, Leon, A, Weiner, C, Tardiff, KLow serum cholesterol level and attempted suicide. Am J Psychiatry 1997;95:212–21.Google Scholar
Golomb, BA, Stattin, H, Mednick, SLow cholesterol and violent crime. J Psychiatry Res 2000;34:301–9.CrossRefGoogle ScholarPubMed
Hillbrand, M, Waite, BM, Miller, DS, Spitz, RT, Lingswiler, VMSerum cholesterol concentrations and mood states in violent psychiatric patients: an experience sampling study. J Behav Med 2000;23:519–29.CrossRefGoogle ScholarPubMed
Kim, YK, Lee, HJ, Kim, JY, Yoon, DK, Choi, SH, Lee, MSLow serum cholesterol is correlated to suicidality in a Korean sample. Acta Psychiatr Scand 2002;105:141–8.CrossRefGoogle Scholar
Kunugi, H, Takei, H, Aoki, H, Nanko, SLow serum cholesterol in suicide attempts. Biol Psychiatr 1997;41:196–200.CrossRefGoogle Scholar
Law, MR, Thompson, SG, Wald, NJAssessing possible hazards of reducing serum cholesterol. BMJ 1994;308:373–9.CrossRefGoogle ScholarPubMed
Linhartová, L. Serum cholesterol and risk of suicide - a clinical catamnestic study. Psychiatrie 1999;3:150–2.Google Scholar
Mann, JJNeurochemical studies of violent and nonviolent suicide. Psychopharmacol Bull 1989;25:407–12.Google ScholarPubMed
Maes, M, Smith, R, Christophe, A, Vandoolaeghe, E, Van Gastel, V, Neels, Het al. Lower serum high density lipoprotein cholesterol (HDL-C) in major depression and in depressed men with serious suicidal attempts: relationship with immune-inflammatory markers. Acta Psychiatr Scand 1994;90:252–8.CrossRefGoogle Scholar
Terao, T, Nakamura, J, Yoshimura, R, Ohmori, O, Takahashi, N, Kojima, Het al. Serum cholesterol levels and suicidal tendencies in psychiatric inpatients. J Clin Psychiatr 1994;55:252–4.Google Scholar
Mufti, RM, Balon, R, Arfkem, CLow cholesterol and violence. Psychiatr Serv 1998;49:221–4.CrossRefGoogle ScholarPubMed
Muldoon, MF, Manuck, SB, Matthews, KALowering cholesterol concentrations and mortality: a quantitative review of primary prevention trials. Br Med J 1990;301:309–14.CrossRefGoogle ScholarPubMed
Muldoon, MF, Manuck, SB, Mendelsohn, AB, Kaplan, JR, Belle, SHCholesterol reduction and non-illness mortality: meta-analysis of randomized clinical trials. Br Med J 2001;322:11–5.CrossRefGoogle Scholar
Partonen, T, Haukka, J, Virtamo, JAssociation of low serum total cholesterol with major depression and suicide. BJP 1999;175:259–62.CrossRefGoogle ScholarPubMed
Pekkanen, J, Nissinen, A, Punsar, S, Karvonen, MJSerum cholesterol and risk of accidental or violent death in a 25 year follow-up: the finnish cohorts of the seven countries study. Arch Intern Med 1989;149:1589–91.CrossRefGoogle ScholarPubMed
Sarchiapone, M, Camardese, G, Roy, A Della Casa S, Satta, MA, Gonzalez, Bet al. Cholesterol and serotonin indices in depressed and suicidal patients. J Affect Disord 2001;3:217–9.CrossRefGoogle Scholar
Steinert, T, Woelfle, M, Gebhardt, RPNo correlation of serum cholesterol levels with measures of violence in patients with schizophrenia and non-psychotic disorders. Eur Psychiatry 1999;14:346–8.CrossRefGoogle ScholarPubMed
Scanlon, SM, Williams, DC, Schloss, PMembrane cholesterol modulates serotonin transporter activity. Biochemistry 2001;3:10507–13.CrossRefGoogle Scholar
Schmidtke, A, Hafner, HThe Werner effect after television films: new evidence for an old hypothesis. Psychol Med 1988;18:665–76.CrossRefGoogle Scholar
Spitz, R, Hillbrand, M, Foster, HSerum cholesterol levels and severity of aggression. Psychol Rep 1994;74:622.CrossRefGoogle Scholar
Steegmans, PH, Fekkes, D, Hoes, AW, Bak, AA van der Does E, Grobbee, DELow serum cholesterol concentration and serotonin metabolism in men. Br Med J 1996:312:221.CrossRefGoogle ScholarPubMed
Strandberg, TE, Saloma, W, Naukkarinen, VA, Vanhanen, HT, Sarna, SJ, Miettinen, TALong term mortality after 5-year multifactorial primary prevention of cardiovascular diseases in middle aged men. JAMA 1991;266:1225–91.CrossRefGoogle ScholarPubMed
Sullivan, PF, Joyce, PR, Bulik, CM, Mulder, RT, Oakley-Browne, MTotal cholesterol and suicidality in depression. Biol. Psychiatr 1994;36:472–7.CrossRefGoogle ScholarPubMed
Tanskanen, AViolent suicide linked to high serum cholesterol levels. Am J Psychiatry 2000;157:648–50.CrossRefGoogle Scholar
Terao, T, Nakamura, J, Yoshimura, R, Ohmori, O, Takahashi, N, Kojima, Het al. Relationship between serum cholesterol levels and meta-chlorophenylpiperazine-induced cortisol responses in healthy men and women. Psychiatry Res 2000;96:167–73.CrossRefGoogle ScholarPubMed
Vevera, J, Papežová, H, Žukov, I, Linhartová, LCholesterol and violent behaviour. CS Psychiatrie 2001;97:69–73.Google Scholar
Virkkunen, MSerum cholesterol in antisocial personality. Neuropsy-chobiology 1979;5:27–30.CrossRefGoogle ScholarPubMed
Virkkunen, MSerum cholesterol levels in homicidal offenders: a low cholesterol level in connected with a habitually violent tendency under the influence of alcohol. Neuropsychobiology 1983;10:65–9.CrossRefGoogle ScholarPubMed
Virkkunen, M, Penttinen, HSerum cholesterol in aggressive conduct disorder: a preliminary study. Biol psychiatry 1984;19:435–9.Google ScholarPubMed
Volavka, JNeurotransmitters, hormones, and genes. Neurobiology of violence 2nd. Washington (DC): American Psychiatric Publishing; 2002. p. 45–81.Google Scholar
Žukov, I, Vevera, J, Morcinek, TLower cholesterol levels in delinquents with affective violent offences as compared with delinquents without violent offences and control group. CS Psychiatrie 2001;8:414–7.Google Scholar
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