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Cannabis use in early adolescence is associated with higher negative schizotypy in females

Published online by Cambridge University Press:  23 March 2020

L. Albertella ,
M.E. Le Pelley  and
J. Copeland
L. Albertella*
Affiliation:
School of Psychology, UNSW Sydney, Kensington, NSW, Australia Brain and Mental Health Laboratory, Monash Institute of Cognitive and Clinical Neurosciences, School of Psychological Sciences, Monash University, Clayton, VIC, Australia
M.E. Le Pelley
Affiliation:
School of Psychology, UNSW Sydney, Kensington, NSW, Australia
J. Copeland
Affiliation:
Cannabis Information and Support, Sydney, NSW, Australia National Cannabis Prevention and Information Centre, UNSW Sydney, Randwick, NSW, Australia
*
*Corresponding author. Brain and Mental Health Laboratory, Monash Institute of Cognitive and Clinical Neurosciences, School of Psychological Sciences, Monash University, 770 Blackburn Road, Clayton, Victoria, 3168, Australia. E-mail address:lucy.albertella@monash.edu (L. Albertella).
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Abstract

The current study examined the relationship between early onset cannabis use (before age 16) and different schizotypy dimensions, and whether gender moderates these associations. Participants were 162 cannabis users, aged 15–24 years, who completed an online assessment examining alcohol and other drug use, psychological distress, and schizotypy. Participants were divided according to whether or not they had started using cannabis before the age of 16 (early onset = 47; later onset = 115) and gender (males = 66; females = 96). The interaction between gender and onset group was significantly associated with the dimension of introvertive anhedonia. Follow-up analyses showed that early onset cannabis use was associated with higher levels of introvertive anhedonia in females only. The current findings suggest that gender is an important moderator in the association between early onset cannabis use, schizotypy, and possibly, psychosis risk.

Keywords

MarijuanaIntrovertive anhedoniaGenderSexPsychosis
Type
Original article
Information
European Psychiatry , Volume 45 , September 2017 , pp. 235 - 241
Copyright
Copyright © European Psychiatric Association 2017

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References

AIHW, National Drug Strategy Household Survey detailed report: 2013; 2014.Google Scholar
Arseneault, LCannon, MPoulton, RMurray, RCaspi, AMoffitt, TECannabis use in adolescence and risk for adult psychosis: Longitudinal prospective study. Bmj 2002; 325(7374): 1212–1213.CrossRefGoogle ScholarPubMed
Di Forti, MMarconi, ACarra, EFraietta, STrotta, ABonomo, M, et al.Proportion of patients in south London with first-episode psychosis attributable to use of high potency cannabis: a case-control study. Lancet Psychiatr 2015; 2(3): 233–238.CrossRefGoogle ScholarPubMed
Ehrenreich, HRinn, TKunert, HJMoeller, MRPoser, WSchilling, L, et al.Specific attentional dysfunction in adults following early start of cannabis use. Psychopharmacology 1999; 142(3): 295–301. http://dx.doi.org/10.1007/s002130050892.CrossRefGoogle ScholarPubMed
Henquet, CKrabbendam, Spauwen, JKaplan, CLieb, RWittchen, H, et al.Prospective cohort study of cannabis use, predisposition for psychosis, and psychotic symptoms in young people. Bmj 2004; 330(7481): 11. http://dx.doi.org/10.1136/bmj.38267.664086.63.CrossRefGoogle ScholarPubMed
Schneider, MKoch, MChronic pubertal, but not adult chronic cannabinoid treatment impairs sensorimotor gating, recognition memory, and the performance in a progressive ratio task in adult rats. Neuropsychopharmacology 2003; 28(10): 1760–1769. http://dx.doi.org/10.1038/sj.npp.1300225.CrossRefGoogle ScholarPubMed
Silins, EHorwood, LJPatton, GCFergusson, DMOlsson, CAHutchinson, DM, et al.Young adult sequelae of adolescent cannabis use: an integrative analysis. Lancet Psychiatr 2014; 1(4): 286–293.CrossRefGoogle ScholarPubMed
Ellgren, MArtmann, ATkalych, OGupta, AHansen, HSHansen, S, et al.Dynamic changes of the endogenous cannabinoid and opioid mesocorticolimbic systems during adolescence: THC effects. Eur Neuropsychopharmacol 2008; 18(11): 826–834.CrossRefGoogle ScholarPubMed
Fernández-ruiz, JGómez, MHernández, MMiguel, RRamos, JCannabinoids and gene expression during brain development. Neurotox Res 2004; 6(5): 389–401. http://dx.doi.org/10.1007/BF03033314.CrossRefGoogle ScholarPubMed
Viveros, MLlorente, RSuarez, JLlorente-Berzal, ALópez-Gallardo, MRodriguez de Fonseca, FThe endocannabinoid system in critical neurodevelopmental periods: sex differences and neuropsychiatric implications. J Psychopharmacol 2012; 26(1): 164–176. http://dx.doi.org/10.1177/0269881111408956.CrossRefGoogle ScholarPubMed
Bossong, MGNiesink, R.J.M.Adolescent brain maturation, the endogenous cannabinoid system and the neurobiology of cannabis-induced schizophrenia. Prog Neurobiol 2010; 92(3): 370–385. http://dx.doi.org/10.1016/j.pneurobio.2010.06.010.CrossRefGoogle ScholarPubMed
Barrantes-Vidal, NGrant, PKwapil, TRThe role of schizotypy in the study of the etiology of schizophrenia spectrum disorders. Schizophr Bull 2015;41:S408–S416. http://dx.doi.org/10.1093/schbul/sbu191.CrossRefGoogle Scholar
Mason, OLinney, YClaridge, GShort scales for measuring schizotypy. Schizophr Res 2005;78(2–3):293–296. http://dx.doi.org/10.1016/j.schres.2005.06.020.CrossRefGoogle ScholarPubMed
Nelson, MTSeal, MLPantelis, CPhillips, LJEvidence of a dimensional relationship between schizotypy and schizophrenia: a systematic review. Neurosci Biobehav Rev 2013; 37(3): 317–327. http://dx.doi.org/10.1016/j.neubiorev.2013.01.004.CrossRefGoogle ScholarPubMed
Szoke, AGalliot, A.-M.Richard, J.-R.Ferchiou, ABaudin, GLeboyer, M, et al. Association between cannabis use and schizotypal dimensions–a meta-analysis of cross-sectional studies. Psychiatr Res 2014CrossRefGoogle Scholar
Stefanis, NCDelespaul, PHenquet, CBakoula, CStefanis, CNVan Os, JEarly adolescent cannabis exposure and positive and negative dimensions of psychosis. Addiction 2004; 99(10): 1333–1341. http://dx.doi.org/10.1111/j.1360-0443.2004.00806.x.CrossRefGoogle Scholar
Albertella, LLe Pelley, MECopeland, JFrequent cannabis use is associated with reduced negative priming among females. Exp Clin Psychopharmacol 2016; 24(5): 313–319.CrossRefGoogle ScholarPubMed
Allegri, FMurri, MBPaparelli, AMarcacci, TBraca, MMenchetti, M, et al.Current cannabis use and age of psychosis onset: a gender-mediated relationship. Results from an 8-year FEP incidence study in Bologna. Psychiatry Res 2013; 210(1): 368–370.CrossRefGoogle ScholarPubMed
Medina, KLMcQueeny, TNagel, BJHanson, KLYang, TTTapert, SFIMAGING STUDY: Prefrontal cortex morphometry in abstinent adolescent marijuana users: subtle gender effects. Addict Biol 2009; 14(4): 457–468. http://dx.doi.org/10.1111/j.1369-1600.2009.00166.x.CrossRefGoogle ScholarPubMed
Rubino, TParolaro, D Sex-dependent vulnerability to cannabis abuse in adolescence. Front Psychiatr 2015;6.CrossRefGoogle Scholar
Norberg, MMMackenzie, JCopeland, JQuantifying cannabis use with the Timeline Followback approach: a psychometric evaluation. Drug Alcohol Depend 2012; 121(3): 247–252. http://dx.doi.org/10.1016/j.drugalcdep.2011.09.007.CrossRefGoogle ScholarPubMed
Albertella, LNorberg, MMMental health symptoms and their relationship to cannabis use in adolescents attending residential treatment. J Psychoactive Drugs 2012; 44(5): 381–389.CrossRefGoogle ScholarPubMed
Swift, WCoffey, CCarlin, JBDegenhardt, LPatton, GCAdolescent cannabis users at 24 years: trajectories to regular weekly use and dependence in young adulthood. Addiction 2008; 103(8): 1361–1370. http://dx.doi.org/10.1111/j.1360-0443.2008.02246.x.CrossRefGoogle ScholarPubMed
Lawrinson, PCopeland, JIndig, DDevelopment and validation of a brief instrument for routine outcome monitoring in opioid maintenance pharmacotherapy services: The Brief Treatment Outcome Measure (BTOM). Drug Alcohol Depend 2005; 80(1): 125–133. http://dx.doi.org/10.1016/j.drugalcdep.2005.04.001.CrossRefGoogle Scholar
Mason, OClaridge, GJackson, MNew scales for the assessment of schizotypy. Personality and Individual differences 1995; 18(1): 7–13.CrossRefGoogle Scholar
Lovibond, SHLovibond, PFManual for the Depression Anxiety Stress Scales Sydney: Psychology Foundation; 1995 [2nd. Ed.].Google Scholar
Albertella, LLe Pelley, MECopeland, JCannabis use, schizotypy, and negative priming. Psychiatry research 2015; 228(3): 404–410.CrossRefGoogle ScholarPubMed
Calkins, MECurtis, CEGrove, WMIacono, WGMultiple dimensions of schizotypy in first degree biological relatives of schizophrenia patients. Schizophr Bull 2004; 30(2): 317–325.CrossRefGoogle ScholarPubMed
Nunn, JARizza, FPeters, ERThe incidence of schizotypy among cannabis and alcohol users. J Nerv Ment Dis 2001; 189(11): 741–748.CrossRefGoogle ScholarPubMed
Tarbox, SIPogue-Geile, MFA multivariate perspective on schizotypy and familial association with schizophrenia: a review. Clin Psychol Rev 2011; 31(7): 1169–1182.CrossRefGoogle ScholarPubMed
Williams, JHWellman, NAAllan, LMTaylor, ETonin, JFeldon, J, et al.Tobacco smoking correlates with schizotypal and borderline personality traits. Personality and Individual differences 1996; 20(2): 267–270. http://dx.doi.org/10.1016/0191-8869(95)00179-4.CrossRefGoogle Scholar
Zamberletti, EPrini, PSpeziali, SGabaglio, MSolinas, MParolaro, D, et al.Gender-dependent behavioral and biochemical effects of adolescent delta-9-tetrahydrocannabinol in adult maternally deprived rats. Neuroscience 2012; 204: 245–257. http://dx.doi.org/10.1016/j.neuroscience.2011.11.038.CrossRefGoogle ScholarPubMed
Burston, JJWiley, JLCraig, AASelley, DESim-Selley, LJRegional enhancement of cannabinoid CB1 receptor desensitization in female adolescent rats following repeated ?9-tetrahydrocannabinol exposure. Br J Pharmacol 2010; 161(1): 103–112.CrossRefGoogle Scholar
Wiers, CEShokri-Kojori, EWong, CTAbi-Dargham, ADemiral, SBTomasi, D, et al.Cannabis Abusers show hypofrontality and blunted brain responses to a stimulant challenge in females but not in males. Neuropsychopharmacology 2016; 41(10): 2596–2605. http://dx.doi.org/10.1038/npp.2016.67.CrossRefGoogle ScholarPubMed
Uroševic, SCollins, PMuetzel, RSchissel, ALim, KOLuciana, MEffects of reward sensitivity and regional brain volumes on substance use initiation in adolescence. Soc Cogn Affect Neurosci 2015; 10(1): 106–113. http://dx.doi.org/10.1093/scan/nsu022.CrossRefGoogle ScholarPubMed
van Hemel-Ruiter, MEde Jong, PJOstafin, BDOldehinkel, AJReward-related attentional bias and adolescent substance use: a prognostic relationship?. PLoS ONE 2015;10(3):e0121058. http://dx.doi.org/10.1371/journal.pone.0121058.CrossRefGoogle ScholarPubMed
Lighthall, NRSakaki, MVasunilashorn, SNga, LSomayajula, SChen, EYMather, MGender differences in reward-related decision processing under stress. Soc Cogn Affect Neurosci 2012; 7(4): 476–484. http://dx.doi.org/10.1093/scan/nsr026.CrossRefGoogle ScholarPubMed
Lighthall, NRMather, MGorlick, MAAcute stress increases sex differences in risk seeking in the balloon analogue risk task. PLoS ONE 2009;4(7):e6002.CrossRefGoogle ScholarPubMed
Power, RAVerweij, K.J.H.Zuhair, MMontgomery, GWHenders, AKHeath, A.C.N.G.Genetic predisposition to schizophrenia associated with increased use of cannabis. Mol Psychiatry 2014. http://dx.doi.org/10.1038/mp.2014.51.CrossRefGoogle Scholar
Hesselbrock, MBabor, TFHesselbrock, VMeyer, REWorkman, KNever believe an alcoholic”? On the validity of self-report measures of alcohol dependence and related constructs. Int J Addictions 1983; 18(5): 593–609. http://dx.doi.org/10.3109/10826088309027359.CrossRefGoogle ScholarPubMed
Martin, GCopeland, JSwift, WThe Adolescent Cannabis Check-Up: Feasibility of a brief intervention for young cannabis users. J Subst Abuse Treat 2005; 29(3): 207–213. http://dx.doi.org/10.1016/j.jsat.2005.06.005.CrossRefGoogle ScholarPubMed
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