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Maternal tobacco smoking in pregnancy and children’s socio-emotional development at age 5: The EDEN mother-child birth cohort study

Published online by Cambridge University Press:  15 April 2020

M. Melchior ,
R. Hersi ,
J. van der Waerden ,
B. Larroque ,
M.-J. Saurel-Cubizolles ,
A. Chollet  and
C. Galéra
M. Melchior*
Affiliation:
INSERM, UMR-S 1136, Department of Social Epidemiology, Pierre-Louis Institute of Epidemiology and Public Health, 75013Paris, France UMR-S 1136, Department of Social Epidemiology, Pierre Louis Institute of Epidemiology and Public Health, Sorbonne Universités, UPMC – Université Paris 06, 75013Paris, France
R. Hersi
Affiliation:
INSERM, UMR-S 1136, Department of Social Epidemiology, Pierre-Louis Institute of Epidemiology and Public Health, 75013Paris, France UMR-S 1136, Department of Social Epidemiology, Pierre Louis Institute of Epidemiology and Public Health, Sorbonne Universités, UPMC – Université Paris 06, 75013Paris, France
J. van der Waerden
Affiliation:
INSERM, UMR-S 1136, Department of Social Epidemiology, Pierre-Louis Institute of Epidemiology and Public Health, 75013Paris, France UMR-S 1136, Department of Social Epidemiology, Pierre Louis Institute of Epidemiology and Public Health, Sorbonne Universités, UPMC – Université Paris 06, 75013Paris, France
B. Larroque
Affiliation:
INSERM, Obstetrical, Perinatal and Pediatric Epidemiology Research Team, Center for Epidemiology and Biostatistics (U1153), Paris-Descartes University, 75020Paris, France UMR-S 953, UPMC – Université Paris 06, 75020Paris, France
M.-J. Saurel-Cubizolles
Affiliation:
INSERM, Obstetrical, Perinatal and Pediatric Epidemiology Research Team, Center for Epidemiology and Biostatistics (U1153), Paris-Descartes University, 75020Paris, France UMR-S 953, UPMC – Université Paris 06, 75020Paris, France
A. Chollet
Affiliation:
INSERM, UMR-S 1136, Department of Social Epidemiology, Pierre-Louis Institute of Epidemiology and Public Health, 75013Paris, France UMR-S 1136, Department of Social Epidemiology, Pierre Louis Institute of Epidemiology and Public Health, Sorbonne Universités, UPMC – Université Paris 06, 75013Paris, France
C. Galéra
Affiliation:
Department of Child and Adolescent Psychiatry, Charles-Perrens Hospital, University of Bordeaux, 33076Bordeaux, France INSERM U897, Center for Research in Epidemiology and Biostatistics, prévention et prise en charge des traumatismes, Bordeaux, France
*
⁎Corresponding author. INSERM, UMR-S 1136, hôpital Paul-Brousse, 16, avenue Paul-Vaillant-Couturier, 94800 Villejuif, France. Tel.: +33 1 77 74 74 27. E-mail address: maria.melchior@inserm.fr (M. Melchior).
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Abstract

Background

There is debate as to whether maternal tobacco use in pregnancy is related to offspring behaviour later on. We tested this association examining multiple aspects of children's behaviour at age 5 and accounting for parental smoking outside of pregnancy, as well as child and family characteristics.

Methods

Data come from a prospective community based birth cohort study (EDEN; n = 1113 families in France followed since pregnancy in 2003–2005 until the child's 5th birthday). Maternal tobacco use in pregnancy was self-reported. Children's socio-emotional development (emotional symptoms, conduct problems, symptoms of hyperactivity/inattention, peer relationship problems, prosocial behaviour) was assessed by mothers using the Strengths and Difficulties Questionnaire (SDQ) at age 5 years. Logistic regression analyses controlled for Inverse Probability Weights (IPW) of maternal tobacco use calculated based on study center, children's characteristics (sex, premature birth, low birth weight, breastfeeding), maternal characteristics (age at the child's birth, psychological difficulties and alcohol use in pregnancy, post-pregnancy depression, and smoking), paternal smoking in and post-pregnancy, parental educational attainment, family income, parental separation, and maternal negative life events.

Results

Maternal smoking in pregnancy only predicted children's high symptoms of hyperactivity/inattention (sex and study center-adjusted ORs: maternal smoking in the 1st trimester: 1.95, 95%CI: 1.13–3.38; maternal smoking throughout pregnancy: OR = 2.11, 95%CI: 1.36–3.27). In IPW-controlled regression models, only children of mothers who smoked throughout pregnancy had significantly elevated levels of hyperactivity/inattention (OR = 2.20, 95%CI: 1.21–4.00).

Conclusions

Maternal tobacco smoking in pregnancy may contribute directly or through epigenetic mechanisms to children's symptoms of hyperactivity/inattention.

Keywords

PregnancyCohort studyCigaretteADHD symptomsAddictionMental health
Type
Original article
Information
European Psychiatry , Volume 30 , Issue 5 , July 2015 , pp. 562 - 568
Copyright
Copyright © Elsevier Masson SAS 2015

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Footnotes

1

Deceased.

2

The EDEN Mother-Child Cohort Study Group: I. Annesi-Maesano, J. Botton, M.A. Charles, P. Dargent-Molina, B. de Lauzon-Guillain, P. Ducimetière, M. de Agostini, B. Foliguet, A. Forhan, X. Fritel, A. Germa, V. Goua, R. Hankard, B. Heude, M. Kaminski, B. Larroque, N. Lelong, J. Lepeule, G. Magnin, L. Marchand, C. Nabet, R. Slama, M.J. Saurel-Cubizolles, M. Schweitzer, O. Thiebaugeorge.

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