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Adipose-derived stromal cells for osteoarticular repair: trophic function versus stem cell activity

  • M. Ruetze (a1) and W. Richter (a1)

The identification of multipotent adipose-derived stromal cells (ASC) has raised hope that tissue regeneration approaches established with bone-marrow-derived stromal cells (BMSC) can be reproduced with a cell-type that is far more accessible in large quantities. Recent detailed comparisons, however, revealed subtle functional differences between ASC and BMSC, stressing the concept of a common mesenchymal progenitor existing in a perivascular niche across all tissues. Focussing on bone and cartilage repair, this review summarises recent in vitro and in vivo studies aiming towards tissue regeneration with ASC. Advantages of good accessibility, high yield and superior growth properties are counterbalanced by an inferiority of ASC to form ectopic bone and stimulate long-bone healing along with their less pronounced osteogenic and angiogenic gene expression signature. Hence, particular emphasis is placed on establishing whether stem cell activity of ASC is so far proven and relevant for successful osteochondral regeneration, or whether trophic activity may largely determine therapeutic outcome.

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*Corresponding author: W. Richter, Research Centre for Experimental Orthopaedics, Heidelberg University Hospital, Schlierbacher Landstrasse 200a, D-69118 Heidelberg, Germany. E-mail:
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1 M. Brittberg (1994) Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. New England Journal of Medicine 331, 889-895

3 S. Marlovits (2006) Cartilage repair: generations of autologous chondrocyte transplantation. European Journal of Radiology 57, 24-31

4 H. Nejadnik (2010) Autologous bone marrow-derived mesenchymal stem cells versus autologous chondrocyte implantation: an observational cohort study. American Journal of Sports Medicine 38, 1110-1116

5 P.A. Zuk (2001) Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Engineering 7, 211-228

6 B.T. Estes (2010) Isolation of adipose-derived stem cells and their induction to a chondrogenic phenotype. Nature Protocols 5, 1294-1311

7 M.J. Oedayrajsingh-Varma (2006) Adipose tissue-derived mesenchymal stem cell yield and growth characteristics are affected by the tissue-harvesting procedure. Cytotherapy 8, 166-177

8 M.F. Pittenger (1999) Multilineage potential of adult human mesenchymal stem cells. Science 284, 143-147

9 S. Gronthos (2001) Surface protein characterization of human adipose tissue-derived stromal cells. Journal of Cellular Physiology 189, 54-63

10 P.A. Zuk (2002) Human adipose tissue is a source of multipotent stem cells. Molecular Biology of the Cell 13, 4279-4295

11 S. Shi and S. Gronthos (2003) Perivascular niche of postnatal mesenchymal stem cells in human bone marrow and dental pulp. Journal of Bone and Mineral Research 18, 696-704

12 A.C. Zannettino (2008) Multipotential human adipose-derived stromal stem cells exhibit a perivascular phenotype in vitro and in vivo. Journal of Cellular Physiology 214, 413-421

13 J.H. Hwang (2013) Combination therapy of human adipose-derived stem cells and basic fibroblast growth factor hydrogel in muscle regeneration. Biomaterials 34, 6037-6045

14 Y.C. Lin (2013) Evaluation of a multi-layer adipose-derived stem cell sheet in a full-thickness wound healing model. Acta Biomaterialia 9, 5243-5250

16 R. Zhang (2012) Nuclear fusion-independent smooth muscle differentiation of human adipose-derived stem cells induced by a smooth muscle environment. Stem Cells 30, 481-490

17 M.S. Rao (2004) Stem sense: a proposal for the classification of stem cells. Stem Cells and Development 13, 452-455

18 P. Bianco (2013) The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine. Nature Medicine 19, 35-42

19 A.J. Becker , C.E. Mc and J.E. Till (1963) Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells. Nature 197, 452-454

20 B. Sacchetti (2007) Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment. Cell 131, 324-336

21 C.K. Chan (2013) Clonal precursor of bone, cartilage, and hematopoietic niche stromal cells. Proceedings of the National Academy Science of the United States of America 110, 12643-12648

22 M. Crisan (2008) A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell 3, 301-313

23 E. Alt (2011) Fibroblasts share mesenchymal phenotypes with stem cells, but lack their differentiation and colony-forming potential. Biology of the Cell 103, 197-208

24 J.B. Mitchell (2006) Immunophenotype of human adipose-derived cells: temporal changes in stromal-associated and stem cell-associated markers. Stem Cells 24, 376-385

25 M. Dominici (2006) Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 8, 315-317

26 P. Hematti (2012) Mesenchymal stromal cells and fibroblasts: a case of mistaken identity? Cytotherapy 14, 516-521

27 C.T. Gomillion and K.J. Burg (2006) Stem cells and adipose tissue engineering. Biomaterials 27, 6052-6063

28 S.W. Cho (2005) Engineering of volume-stable adipose tissues. Biomaterials 26, 3577-3585

29 M. Halbleib (2003) Tissue engineering of white adipose tissue using hyaluronic acid-based scaffolds. I. In vitro differentiation of human adipocyte precursor cells on scaffolds. Biomaterials 24, 3125-3132

30 K. Hemmrich (2005) Implantation of preadipocyte-loaded hyaluronic acid-based scaffolds into nude mice to evaluate potential for soft tissue engineering. Biomaterials 26, 7025-7037

31 P.N. Patel (2005) Poly(ethylene glycol) hydrogel system supports preadipocyte viability, adhesion, and proliferation. Tissue Engineering 11, 1498-1505

32 L. Hong (2005) Ex vivo adipose tissue engineering by human marrow stromal cell seeded gelatin sponge. Annals of Biomedical Engineering 33, 511-517

33 J.R. Mauney , V. Volloch and D.L. Kaplan (2005) Matrix-mediated retention of adipogenic differentiation potential by human adult bone marrow-derived mesenchymal stem cells during ex vivo expansion. Biomaterials 26, 6167-6175

34 M. Neubauer (2005) Adipose tissue engineering based on mesenchymal stem cells and basic fibroblast growth factor in vitro. Tissue Engineering 11, 1840-1851

35 M. Vermette (2007) Production of a new tissue-engineered adipose substitute from human adipose-derived stromal cells. Biomaterials 28, 2850-2860

36 H. Mizuno (2008) In vivo adipose tissue regeneration by adipose-derived stromal cells isolated from GFP transgenic mice. Cells Tissues Organs 187, 177-185

37 W. Jing (2007) Ectopic adipogenesis of preconditioned adipose-derived stromal cells in an alginate system. Cell and Tissue Research 330, 567-572

39 B.O. Diekman (2010) Chondrogenesis of adult stem cells from adipose tissue and bone marrow: induction by growth factors and cartilage-derived matrix. Tissue Engineering A 16, 523-533

40 A. Shafiee (2011) A comparison between osteogenic differentiation of human unrestricted somatic stem cells and mesenchymal stem cells from bone marrow and adipose tissue. Biotechnology Letters 33, 1257-1264

41 Z. Zhou (2013) Comparison of mesenchymal stromal cells from human bone marrow and adipose tissue for the treatment of spinal cord injury. Cytotherapy 15, 434-448

42 R.I. Dmitrieva (2012) Bone marrow- and subcutaneous adipose tissue-derived mesenchymal stem cells: differences and similarities. Cell Cycle 11, 377-383

43 S. Kern (2006) Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells 24, 1294-1301

44 L. Peng (2008) Comparative analysis of mesenchymal stem cells from bone marrow, cartilage, and adipose tissue. Stem Cells and Development 17, 761-773

45 T. Schubert (2011) The enhanced performance of bone allografts using osteogenic-differentiated adipose-derived mesenchymal stem cells. Biomaterials 32, 8880-8891

46 L. Danisovic (2009) Comparison of in vitro chondrogenic potential of human mesenchymal stem cells derived from bone marrow and adipose tissue. General Physiology and Biophysics 28, 56-62

48 D.A. De Ugarte (2003) Differential expression of stem cell mobilization-associated molecules on multi-lineage cells from adipose tissue and bone marrow. Immunology Letters 89, 267-270

49 P. Niemeyer (2007) Comparison of immunological properties of bone marrow stromal cells and adipose tissue-derived stem cells before and after osteogenic differentiation in vitro. Tissue Engineering 13, 111-121

50 G. Pachon-Pena (2011) Stromal stem cells from adipose tissue and bone marrow of age-matched female donors display distinct immunophenotypic profiles. Journal of Cellular Physiology 226, 843-851

51 S. Boeuf and W. Richter (2010) Chondrogenesis of mesenchymal stem cells: role of tissue source and inducing factors. Stem Cell Research & Therapy 1, 31-40

52 D. Noel (2008) Cell specific differences between human adipose-derived and mesenchymal-stromal cells despite similar differentiation potentials. Experimental Cell Research 314, 1575-1584

53 D.A. Rider (2008) Autocrine fibroblast growth factor 2 increases the multipotentiality of human adipose-derived mesenchymal stem cells. Stem Cells 26, 1598-1608

54 Y. Ikegame (2011) Comparison of mesenchymal stem cells from adipose tissue and bone marrow for ischemic stroke therapy. Cytotherapy 13, 675-685

55 I.M. Shih (1999) The role of CD146 (Mel-CAM) in biology and pathology. Journal of Pathology 189, 4-11

56 M. Ruetze (2013) A novel niche for skin derived precursors in non-follicular skin. Journal of Dermatological Science 69, 132-139

57 A. Sorrentino (2008) Isolation and characterization of CD146+ multipotent mesenchymal stromal cells. Experimental Hematology 36, 1035-1046

58 D.T. Covas (2008) Multipotent mesenchymal stromal cells obtained from diverse human tissues share functional properties and gene-expression profile with CD146+ perivascular cells and fibroblasts. Experimental Hematology 36, 642-654

59 J. Brocher (2013) Inferior ectopic bone formation of mesenchymal stromal cells from adipose tissue compared to bone-marrow: rescue by chondrogenic pre-induction. Stem Cell Res 11(3), 1393-406

60 K. Yoshimura (2006) Characterization of freshly isolated and cultured cells derived from the fatty and fluid portions of liposuction aspirates. Journal of Cellular Physiology 208, 64-76

61 M. Maumus (2011) Native human adipose stromal cells: localization, morphology and phenotype. International Journal of Obesity (London) 35, 1141-1153

62 T. Hennig (2007) Reduced chondrogenic potential of adipose tissue derived stromal cells correlates with an altered TGFbeta receptor and BMP profile and is overcome by BMP-6. Journal of Cellular Physiology 211, 682-691

63 R.H. Lee (2004) Characterization and expression analysis of mesenchymal stem cells from human bone marrow and adipose tissue. Cellular Physiology and Biochemistry 14, 311-324

64 M. Al-Nbaheen (2013) Human stromal (mesenchymal) stem cells from bone marrow, adipose tissue and skin exhibit differences in molecular phenotype and differentiation potential. Stem Cell Reviews 9, 32-43

65 S. Boeuf (2009) Enhanced ITM2A expression inhibits chondrogenic differentiation of mesenchymal stem cells. Differentiation 78, 108-115

66 E. Monaco (2012) Transcriptomics comparison between porcine adipose and bone marrow mesenchymal stem cells during in vitro osteogenic and adipogenic differentiation. PLoS ONE 7, e32481

67 C. Nakanishi (2011) Gene and protein expression analysis of mesenchymal stem cells derived from rat adipose tissue and bone marrow. Circulation Journal 75, 2260-2268

68 G.I. Im , Y.W. Shin and K.B. Lee (2005) Do adipose tissue-derived mesenchymal stem cells have the same osteogenic and chondrogenic potential as bone marrow-derived cells? Osteoarthritis and Cartilage 13, 845-853

69 T.M. Liu (2007) Identification of common pathways mediating differentiation of bone marrow- and adipose tissue-derived human mesenchymal stem cells into three mesenchymal lineages. Stem Cells 25, 750-760

70 J.I. Huang (2005) Chondrogenic potential of progenitor cells derived from human bone marrow and adipose tissue: a patient-matched comparison. Journal of Orthopaedic Research 23, 1383-1389

72 Y.A. Choi (2010) Secretome analysis of human BMSCs and identification of SMOC1 as an important ECM protein in osteoblast differentiation. Journal of Proteome Research 9, 2946-2956

73 M. Polacek (2011) The secretory profiles of cultured human articular chondrocytes and mesenchymal stem cells: implications for autologous cell transplantation strategies. Cell Transplantation 20, 1381-1393

74 H. Skalnikova (2011) Mapping of the secretome of primary isolates of mammalian cells, stem cells and derived cell lines. Proteomics 11, 691-708

75 Y. Saito (2013) The protective effect of adipose-derived stem cells against liver injury by trophic molecules. Journal of Surgical Research 180, 162-168

76 X. Wei (2009) IFATS collection: the conditioned media of adipose stromal cells protect against hypoxia-ischemia-induced brain damage in neonatal rats. Stem Cells 27, 478-488

77 S. Sadat (2007) The cardioprotective effect of mesenchymal stem cells is mediated by IGF-I and VEGF. Biochemical and Biophysical Research Communications 363, 674-679

78 Y.S. Park (2012) Improved viability and activity of neutrophils differentiated from HL-60 cells by co-culture with adipose tissue-derived mesenchymal stem cells. Biochemical and Biophysical Research Communications 423, 19-25

79 W. Peng (2012) Adipose-derived stem cells induced dendritic cells undergo tolerance and inhibit Th1 polarization. Cellular Immunology 278, 152-157

80 B. Puissant (2005) Immunomodulatory effect of human adipose tissue-derived adult stem cells: comparison with bone marrow mesenchymal stem cells. British Journal of Haematology 129, 118-129

82 J. Rehman (2004) Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. Circulation 109, 1292-1298

83 C. Chiellini (2008) Characterization of human mesenchymal stem cell secretome at early steps of adipocyte and osteoblast differentiation. BMC Molecular Biology 9, 26

84 M.J. Lee (2010) Proteomic analysis of tumor necrosis factor-alpha-induced secretome of human adipose tissue-derived mesenchymal stem cells. Journal of Proteome Research 9, 1754-1762

85 S. Zvonic (2007) Secretome of primary cultures of human adipose-derived stem cells: modulation of serpins by adipogenesis. Molecular & Cellular Proteomics 6, 18-28

86 C.S. Lee (2012) Adipose stem cells can secrete angiogenic factors that inhibit hyaline cartilage regeneration. Stem Cell Research & Therapy 3, 35

87 S.P. Blaber (2012) Analysis of in vitro secretion profiles from adipose-derived cell populations. Journal of Translational Medicine 10, 172

88 L. Cai (2009) IFATS collection: human adipose tissue-derived stem cells induce angiogenesis and nerve sprouting following myocardial infarction, in conjunction with potent preservation of cardiac function. Stem Cells 27, 230-237

89 G.E. Kilroy (2007) Cytokine profile of human adipose-derived stem cells: expression of angiogenic, hematopoietic, and pro-inflammatory factors. Journal of Cellular Physiology 212, 702-709

91 A.I. Caplan and J.E. Dennis (2006) Mesenchymal stem cells as trophic mediators. Journal of Cellular Biochemistry 98, 1076-1084

93 P. Kasten (2008) Porosity and pore size of beta-tricalcium phosphate scaffold can influence protein production and osteogenic differentiation of human mesenchymal stem cells: an in vitro and in vivo study. Acta Biomaterialia 4, 1904-1915

94 P. Janicki (2010) Chondrogenic pre-induction of human mesenchymal stem cells on beta-TCP: enhanced bone quality by endochondral heterotopic bone formation. Acta Biomaterialia 6, 3292-3301

95 P. Kasten (2005) Ectopic bone formation associated with mesenchymal stem cells in a resorbable calcium deficient hydroxyapatite carrier. Biomaterials 26, 5879-5889

96 P.H. Krebsbach (1997) Bone formation in vivo: comparison of osteogenesis by transplanted mouse and human marrow stromal fibroblasts. Transplantation 63, 1059-1069

97 M.H. Mankani (2006) In vivo bone formation by human bone marrow stromal cells: reconstruction of the mouse calvarium and mandible. Stem Cells 24, 2140-2149

98 W. Hao (2008) Collagen I gel can facilitate homogenous bone formation of adipose-derived stem cells in PLGA-beta-TCP scaffold. Cells Tissues Organs 187, 89-102

100 H. Hattori (2004) Osteogenic potential of human adipose tissue-derived stromal cells as an alternative stem cell source. Cells Tissues Organs 178, 2-12

102 S.J. Lee (2010) Enhancement of bone regeneration by gene delivery of BMP2/Runx2 bicistronic vector into adipose-derived stromal cells. Biomaterials 31, 5652-5659

103 M. Yang (2005) In vitro and in vivo induction of bone formation based on ex vivo gene therapy using rat adipose-derived adult stem cells expressing BMP-7. Cytotherapy 7, 273-281

104 E. Steck (2010) Discrimination between cells of murine and human origin in xenotransplants by species specific genomic in situ hybridization. Xenotransplantation 17, 153-159

105 A. Scherberich (2007) Three-dimensional perfusion culture of human adipose tissue-derived endothelial and osteoblastic progenitors generates osteogenic constructs with intrinsic vascularization capacity. Stem Cells 25, 1823-1829

107 X.B. Jin (2007) Neocartilage formation from predifferentiated human adipose derived stem cells in vivo. Acta Pharmacologica Sinica 28, 663-671

108 H.H. Yoon (2012) Enhanced cartilage formation via three-dimensional cell engineering of human adipose-derived stem cells. Tissue Engineering A 18, 1949-1956

109 X. Jin (2007) Ectopic neocartilage formation from predifferentiated human adipose derived stem cells induced by adenoviral-mediated transfer of hTGF beta2. Biomaterials 28, 2994-3003

110 Y. Jung (2009) In situ chondrogenic differentiation of human adipose tissue-derived stem cells in a TGF-beta1 loaded fibrin-poly(lactide-caprolactone) nanoparticulate complex. Biomaterials 30, 4657-4664

111 A.T. Mehlhorn (2009) Chondrogenesis of adipose-derived adult stem cells in a poly-lactide-co-glycolide scaffold. Tissue Engineering A 15, 1159-1167

112 K. Pelttari (2006) Premature induction of hypertrophy during in vitro chondrogenesis of human mesenchymal stem cells correlates with calcification and vascular invasion after ectopic transplantation in SCID mice. Arthritis & Rheumatology 54, 3254-3266

113 G.P. Dowthwaite (2004) The surface of articular cartilage contains a progenitor cell population. Journal of Cell Science 117(Pt 6), 889-897

114 M. ter Huurne (2012) Antiinflammatory and chondroprotective effects of intraarticular injection of adipose-derived stem cells in experimental osteoarthritis. Arthritis & Rheumatology 64, 3604-3613

115 G. Desando (2013) Intra-articular delivery of adipose derived stromal cells attenuates osteoarthritis progression in an experimental rabbit model. Arthritis Research & Therapy 15, R22

117 J.L. Dragoo (2007) Healing full-thickness cartilage defects using adipose-derived stem cells. Tissue Engineering 13, 1615-1621

118 G.I. Im , H.J. Kim and J.H. Lee (2011) Chondrogenesis of adipose stem cells in a porous PLGA scaffold impregnated with plasmid DNA containing SOX trio (SOX-5,-6 and -9) genes. Biomaterials 32, 4385-4392

119 L. Cui (2009) Repair of articular cartilage defect in non-weight bearing areas using adipose derived stem cells loaded polyglycolic acid mesh. Biomaterials 30, 2683-2693

120 T. Matsumoto (2010) Articular cartilage repair with autologous bone marrow mesenchymal cells. Journal of Cellular Physiology 225, 291-295

121 M.M. Wilke , D.V. Nydam and A.J. Nixon (2007) Enhanced early chondrogenesis in articular defects following arthroscopic mesenchymal stem cell implantation in an equine model. Journal of Orthopaedic Research 25, 913-925

122 C.T. Lim (2013) Repair of osteochondral defects with rehydrated freeze-dried oligo[poly(ethylene glycol) fumarate] hydrogels seeded with bone marrow mesenchymal stem cells in a porcine model. Tissue Engineering A 19, 1852-1861

123 J.A. Conejero (2006) Repair of palatal bone defects using osteogenically differentiated fat-derived stem cells. Plastic and Reconstructive Surgery 117, 857-863

124 L. Cui (2007) Repair of cranial bone defects with adipose derived stem cells and coral scaffold in a canine model. Biomaterials 28, 5477-5486

125 C. Di Bella , P. Farlie and A.J. Penington (2008) Bone regeneration in a rabbit critical-sized skull defect using autologous adipose-derived cells. Tissue Engineering A 14, 483-490

126 J.R. Dudas (2006) The osteogenic potential of adipose-derived stem cells for the repair of rabbit calvarial defects. Annals of Plastic Surgery 56, 543-548

127 J.Y. Kim (2010) Evaluation of solid free-form fabrication-based scaffolds seeded with osteoblasts and human umbilical vein endothelial cells for use in vivo osteogenesis. Tissue Engineering A 16, 2229-2236

128 E. Yoon (2007) In vivo osteogenic potential of human adipose-derived stem cells/poly lactide-co-glycolic acid constructs for bone regeneration in a rat critical-sized calvarial defect model. Tissue Engineering 13, 619-627

129 Q. Chen (2010) Adipose-derived stem cells modified genetically in vivo promote reconstruction of bone defects. Cytotherapy 12, 831-840

130 D. Han and J. Li (2013) Repair of bone defect by using vascular bundle implantation combined with Runx II gene-transfected adipose-derived stem cells and a biodegradable matrix. Cell and Tissue Research 352, 561-571

131 C.Y. Lin (2012) Immune responses during healing of massive segmental femoral bone defects mediated by hybrid baculovirus-engineered ASCs. Biomaterials 33, 7422-7434

132 B. Peterson (2005) Healing of critically sized femoral defects, using genetically modified mesenchymal stem cells from human adipose tissue. Tissue Engineering 11, 120-129

133 D. Sheyn (2011) Gene-modified adult stem cells regenerate vertebral bone defect in a rat model. Molecular Pharmaceutics 8, 1592-1601

134 R.C. de Guzman (2013) Bone regeneration with BMP-2 delivered from keratose scaffolds. Biomaterials 34, 1644-1656

135 J.O. Teixeira and M.R. Urist (1998) Bone morphogenetic protein induced repair of compartmentalized segmental diaphyseal defects. Archives of Orthopaedic and Trauma Surgery 117, 27-34

136 K.K. Wurzler (1998) Radiation-induced impairment of bone healing can be overcome by recombinant human bone morphogenetic protein-2. Journal of Craniofacial Surgery 9, 131-137

137 Y.F. Chou (2011) Adipose-derived stem cells and BMP2. Part 1. BMP2-treated adipose-derived stem cells do not improve repair of segmental femoral defects. Connective Tissue Research 52, 109-118

138 C. Keibl (2011) Human adipose derived stem cells reduce callus volume upon BMP-2 administration in bone regeneration. Injury 42, 814-820

139 K. Mesimaki (2009) Novel maxillary reconstruction with ectopic bone formation by GMP adipose stem cells. International Journal of Oral and Maxillofacial Surgery 38, 201-209

140 G.K. Sandor (2012) Tissue engineering of bone: clinical observations with adipose-derived stem cells, resorbable scaffolds, and growth factors. Annals of Maxillofacial Surgery 2, 8-11

141 D.M. Smith (2011) Regenerative surgery in cranioplasty revisited: the role of adipose-derived stem cells and BMP-2. Plastic and Reconstructive Surgery 128, 1053-1060

142 B. Levi (2010) Human adipose derived stromal cells heal critical size mouse calvarial defects. PLoS ONE 5, e11177

143 P. Niemeyer (2010) Comparison of mesenchymal stem cells from bone marrow and adipose tissue for bone regeneration in a critical size defect of the sheep tibia and the influence of platelet-rich plasma. Biomaterials 31, 3572-3579

144 C.M. Cowan (2004) Adipose-derived adult stromal cells heal critical-size mouse calvarial defects. Nature Biotechnology 22, 560-567

145 B. Levi (2011) Differences in osteogenic differentiation of adipose-derived stromal cells from murine, canine, and human sources in vitro and in vivo. Plastic and Reconstructive Surgery 128, 373-386

146 P. Streckbein (2013) Reconstruction of critical-size mandibular defects in immunoincompetent rats with human adipose-derived stromal cells. Journal of Craniomaxillofacial Surgery 41, 496-503

147 S.M. Wilson (2012) Adipose-derived mesenchymal stem cells enhance healing of mandibular defects in the ramus of swine. Journal of Oral and Maxillofacial Surgery 70, e193-e203

148 S. Kachgal and A.J. Putnam (2011) Mesenchymal stem cells from adipose and bone marrow promote angiogenesis via distinct cytokine and protease expression mechanisms. Angiogenesis 14, 47-59

149 P. Niemeyer (2008) Survival of human mesenchymal stromal cells from bone marrow and adipose tissue after xenogenic transplantation in immunocompetent mice. Cytotherapy 10(8), 784-95

150 K.C. Hicok (2004) Human adipose-derived adult stem cells produce osteoid in vivo. Tissue Eng 10(3-4), 371-80

151 P. Supronowicz (2011) Human adipose-derived side population stem cells cultured on demineralized bone matrix for bone tissue engineering. Tissue Eng Part A 17(5-6), 789-98

152 J. Yao (2010) Ectopic bone formation in adipose-derived stromal cell-seeded osteoinductive calcium phosphate scaffolds. J Biomater Appl 24(7), 607-24

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