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    Chen, Peng Zhou, Qingjun Wang, Junyi Zhao, Xiaowen Duan, Haoyun Wang, Yao Liu, Ting and Xie, Lixin 2016. Characterization of the corneal surface in limbal stem cell deficiency and after transplantation of cultured allogeneic limbal epithelial cells. Graefe's Archive for Clinical and Experimental Ophthalmology,


    Chirila, T.V. Suzuki, S. Hirst, L.W. and Harkin, D.G. 2016. Biomaterials and Regenerative Medicine in Ophthalmology.


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    Tan, Tien-En Peh, Gary S. L. Finkelstein, Eric A. and Mehta, Jodhbir S. 2015. A practical model for economic evaluation of tissue-engineered therapies. Wiley Interdisciplinary Reviews: Systems Biology and Medicine, Vol. 7, Issue. 2, p. 91.


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  • Expert Reviews in Molecular Medicine, Volume 15
  • 2013, e4

Ex-vivo ocular surface stem cell therapies: current techniques, applications, hurdles and future directions

  • Romesh I. Angunawela (a1), Jodhbir S. Mehta (a2) (a3) and Julie T. Daniels (a4)
  • DOI: http://dx.doi.org/10.1017/erm.2013.5
  • Published online: 01 June 2013
Abstract

Engineered tissue derived from ocular surface stem cells (SCs) are a cutting edge biotechnology for repair and restoration of severely damaged eyes as a result of ocular surface dysfunction because of SC failure. Ex-vivo SC expansion techniques have advanced significantly since the first patients were treated in the late 1990s. The techniques and clinical reports reviewed here highlight the evolution and successes of these techniques, while also revealing gaps in our understanding of ocular surface and SC biology that drives further research and development in this field. Although hurdles still remain before stem-cell-based therapies are more widely available for patients with devastating ocular surface disease, recent discoveries in the field of mesenchymal SCs and the potential of induced pluripotent SCs heralds a promising future for clinicians and our patients.

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Corresponding author
*Corresponding author: Julie T. Daniels, Department of Ocular Biology and Therapeutics, UCL Institute of Ophthalmology, 11-43 Bath Street, London EC1 V 9EL, UK. E-mail: j.daniels@ucl.ac.uk
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Expert Reviews in Molecular Medicine
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