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  • Expert Reviews in Molecular Medicine, Volume 11
  • 2009, e2

Inflammation and neuropeptides: the connection in diabetic wound healing

  • Leena Pradhan (a1), Christoph Nabzdyk (a2), Nicholas D. Andersen (a1), Frank W. LoGerfo (a1) and Aristidis Veves (a3)
  • DOI: http://dx.doi.org/10.1017/S1462399409000945
  • Published online: 01 January 2009
Abstract

Abnormal wound healing is a major complication of both type 1 and type 2 diabetes, with nonhealing foot ulcerations leading in the worst cases to lower-limb amputation. Wound healing requires the integration of complex cellular and molecular events in successive phases of inflammation, cell proliferation, cell migration, angiogenesis and re-epithelialisation. A link between wound healing and the nervous system is clinically apparent as peripheral neuropathy is reported in 30–50% of diabetic patients and is the most common and sensitive predictor of foot ulceration. Indeed, a bidirectional connection between the nervous and the immune systems and its role in wound repair has emerged as one of the focal features of the wound-healing dogma. This review provides a broad overview of the mediators of this connection, which include neuropeptides and cytokines released from nerve fibres, immune cells and cutaneous cells. In-depth understanding of the signalling pathways in the neuroimmune axis in diabetic wound healing is vital to the development of successful wound-healing therapies.

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Corresponding author
*Corresponding author: Aristidis Veves, Microcirculation Laboratory, Beth Israel Deaconess Medical Center, Palmer 317, West Campus, One Deaconess Rd, Boston, MA 02215, USA. Tel: +1 617 632 7075; Fax: +1 617 632 0860; E-mail: aveves@bidmc.harvard.edu
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This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

1[No authors listed] (2008) Economic costs of diabetes in the U.S. in 2007. Diabetes Care 31, 596-615

3A.J. Boulton (2005) The global burden of diabetic foot disease. Lancet 366, 1719-1724

5F. Thomson (1991) A team approach to diabtic foot care–the Manchester experience. The Foot 1, 75-82

6V. Falanga (2005) Wound healing and its impairment in the diabetic foot. Lancet 366, 1736-1743

7J.D. Bagdade , R.K. Root and R.J. Bulger (1974) Impaired leukocyte function in patients with poorly controlled diabetes. Diabetes 23, 9-15

8C.M. Nolan , H.N. Beaty and J.D. Bagdade (1978) Further characterization of the impaired bactericidal function of granulocytes in patients with poorly controlled diabetes. Diabetes 27, 889-894

9V. Falanga (1993) Chronic wounds: pathophysiologic and experimental considerations. Journal of Investigative Dermatology 100, 721-725

10A.L. Claudy (1991) Detection of undegraded fibrin and tumor necrosis factor-alpha in venous leg ulcers. Journal of the American Academy of Dermatology 25, 623-627

11M.A. Loots (1998) Differences in cellular infiltrate and extracellular matrix of chronic diabetic and venous ulcers versus acute wounds. Journal of Investigative Dermatology 111, 850-857

12K. Rosner (1995) Immunohistochemical characterization of the cutaneous cellular infiltrate in different areas of chronic leg ulcers. APMIS 103, 293-299

13K. Moore , F. Ruge and K.G. Harding (1997) T lymphocytes and the lack of activated macrophages in wound margin biopsies from chronic leg ulcers. British Journal of Dermatology 137, 188-194

15Y. Duraisamy (2001) Effect of glycation on basic fibroblast growth factor induced angiogenesis and activation of associated signal transduction pathways in vascular endothelial cells: possible relevance to wound healing in diabetes. Angiogenesis 4, 277-288

16I.J. Elenkov (2008) Neurohormonal-cytokine interactions: implications for inflammation, common human diseases and well-being. Neurochemistry International 52, 40-51

17E. Engelhardt (1998) Chemokines IL-8, GROalpha, MCP-1, IP-10, and Mig are sequentially and differentially expressed during phase-specific infiltration of leukocyte subsets in human wound healing. American Journal of Pathology 153, 1849-1860

19A. Trautmann (2000) Mast cell involvement in normal human skin wound healing: expression of monocyte chemoattractant protein-1 is correlated with recruitment of mast cells which synthesize interleukin-4 in vivo. Journal of Pathology 190, 100-106

23F. Hildebrand , H.C. Pape and C. Krettek (2005) [The importance of cytokines in the posttraumatic inflammatory reaction.] Unfallchirurg 108, 793-794, 796–803 [Article in German]

25H. Tilg and A.R. Moschen (2008) Inflammatory mechanisms in the regulation of insulin resistance. Molecular Medicine 14, 222-231

26P. Bogdanski (2007) Influence of insulin therapy on expression of chemokine receptor CCR5 and selected inflammatory markers in patients with type 2 diabetes mellitus. International Journal of Clinical Pharmacology and Therapeutics 45, 563-567

28J.S. Rosa (2008) Sustained IL-1alpha, IL-4, and IL-6 elevations following correction of hyperglycemia in children with type 1 diabetes mellitus. Pediatric Diabetes 9, 9-16

29S. Devaraj (2006) Increased monocytic activity and biomarkers of inflammation in patients with type 1 diabetes. Diabetes 55, 774-779

31K. Kempf (2007) The metabolic syndrome sensitizes leukocytes for glucose-induced immune gene expression. Journal of Molecular Medicine 85, 389-396

33E. Hatanaka (2006) Neutrophils and monocytes as potentially important sources of proinflammatory cytokines in diabetes. Clinical and Experimental Immunology 146, 443-447

34W.L. Hand , D.L. Hand and Y. Vasquez (2007) Increased polymorphonuclear leukocyte respiratory burst function in type 2 diabetes. Diabetes Research and Clinical Practice 76, 44-50

35M.E. Stegenga (2008) Effect of acute hyperglycaemia and/or hyperinsulinaemia on proinflammatory gene expression, cytokine production and neutrophil function in humans. Diabetic Medicine 25, 157-164

36T.C. Alba-Loureiro (2006) Diabetes causes marked changes in function and metabolism of rat neutrophils. Journal of Endocrinology 188, 295-303

37K. Mastej and R. Adamiec (2008) Neutrophil surface expression of CD11b and CD62L in diabetic microangiopathy. Acta Diabetologica 45, 183-190

38W. Marhoffer (1993) Evidence of ex vivo and in vitro impaired neutrophil oxidative burst and phagocytic capacity in type 1 diabetes mellitus. Diabetes Research and Clinical Practice 19, 183-188

39T.C. Alba-Loureiro (2007) Neutrophil function and metabolism in individuals with diabetes mellitus. Brazilian Journal of Medical and Biological Research 40, 1037-1044

40O. Oncul (2007) Effect of the function of polymorphonuclear leukocytes and interleukin-1 beta on wound healing in patients with diabetic foot infections. Journal of Infection 54, 250-256

41O. Ochoa , F.M. Torres and P.K. Shireman (2007) Chemokines and diabetic wound healing. Vascular 15, 350-355

42N. Shanmugam , R.M. Ransohoff and R. Natarajan (2006) Interferon-gamma-inducible protein (IP)-10 mRNA stabilized by RNA-binding proteins in monocytes treated with S100b. Journal of Biological Chemistry 281, 31212-31221

43N. Shanmugam (2008) Proinflammatory effects of advanced lipoxidation end products in monocytes. Diabetes 57, 879-888

44H. Galkowska , U. Wojewodzka and W.L. Olszewski (2006) Chemokines, cytokines, and growth factors in keratinocytes and dermal endothelial cells in the margin of chronic diabetic foot ulcers. Wound Repair and Regeneration 14, 558-565

45P.S. Laine (2007) Palmitic acid induces IP-10 expression in human macrophages via NF-kappaB activation. Biochemical and Biophysical Research Communications 358, 150-155

46N. Maulik and D.K. Das (2002) Redox signaling in vascular angiogenesis. Free Radical Biology and Medicine 33, 1047-1060

48H. Lateef (2005) Pretreatment of diabetic rats with lipoic acid improves healing of subsequently-induced abrasion wounds. Archives of Dermatological Research 297, 75-83

49S. Straino (2008) High-mobility group box 1 protein in human and murine skin: involvement in wound healing. Journal of Investigative Dermatology 128, 1545-1553

50J.J. Corrales (2007) Decreased production of inflammatory cytokines by circulating monocytes and dendritic cells in type 2 diabetic men with atherosclerotic complications. Journal of Diabetes and its Complications 21, 41-49

51K. Maruyama (2007) Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing. American Journal of Pathology 170, 1178-1191

52V. Urbancic-Rovan (2005) Causes of diabetic foot lesions. Lancet 366, 1675-1676

53P. Sheehan (2003) Percent change in wound area of diabetic foot ulcers over a 4-week period is a robust predictor of complete healing in a 12-week prospective trial. Diabetes Care 26, 1879-1882

54M.J. Young , J.L. Breddy , A. Veves and A.J. Boulton (1994) The prediction of diabetic neuropathic foot ulceration using vibration perception thresholds. A prospective study. Diabetes Care 17, 557-560

55A.I. Adler (1997) Risk factors for diabetic peripheral sensory neuropathy. Results of the Seattle Prospective Diabetic Foot Study. Diabetes Care 20, 1162-1167

56G.E. Reiber (1999) Causal pathways for incident lower-extremity ulcers in patients with diabetes from two settings. Diabetes Care 22, 157-162

57J.S. Yao (2006) Interleukin-6 triggers human cerebral endothelial cells proliferation and migration: the role for KDR and MMP-9. Biochemical and Biophysical Research Communications 342, 1396-1404

59M. Lindberger (1989) Nerve fibre studies in skin biopsies in peripheral neuropathies. I. Immunohistochemical analysis of neuropeptides in diabetes mellitus. Journal of the Neurological Sciences 93, 289-296

58A.I. Vinik (2000) Diabetic neuropathies. Diabetologia 43, 957-973

60H. Galkowska (2006) Neurogenic factors in the impaired healing of diabetic foot ulcers. Journal of Surgical Research 134, 252-258

61C. Quattrini , M. Jeziorska and R.A. Malik (2004) Small fiber neuropathy in diabetes: clinical consequence and assessment. The International Journal of Lower Extremity Wounds 3, 16-21

62T.A. Luger (2002) Neuromediators–a crucial component of the skin immune system. Journal of Dermatological Science 30, 87-93

63I. Berczi (1996) The immune effects of neuropeptides. Baillieres Clinical Rheumatology 10, 227-257

64S.T. Krishnan (2007) Neurovascular factors in wound healing in the foot skin of type 2 diabetic subjects. Diabetes Care 30, 3058-3062

65F.B. Pomposelli (2003) A decade of experience with dorsalis pedis artery bypass: analysis of outcome in more than 1000 cases. Journal of Vascular Surgery 37, 307-315

66I. Vareniuk , I.A. Pavlov and I.G. Obrosova (2008) Inducible nitric oxide synthase gene deficiency counteracts multiple manifestations of peripheral neuropathy in a streptozotocin-induced mouse model of diabetes. Diabetologia 51, 2126-2133

67I.G. Obrosova (2005) Oxidative-nitrosative stress and poly(ADP-ribose) polymerase (PARP) activation in experimental diabetic neuropathy: the relation is revisited. Diabetes 54, 3435-3441

68A.P. Kellogg (2007) Protective effects of cyclooxygenase-2 gene inactivation against peripheral nerve dysfunction and intraepidermal nerve fiber loss in experimental diabetes. Diabetes 56, 2997-3005

69I.G. Obrosova (2007) High-fat diet induced neuropathy of pre-diabetes and obesity: effects of “healthy” diet and aldose reductase inhibition. Diabetes 56, 2598-2608

70D. Roosterman (2006) Neuronal control of skin function: the skin as a neuroimmunoendocrine organ. Physiological Reviews 86, 1309-1379

71M. Nakamura (2003) Promotion of corneal epithelial wound healing in diabetic rats by the combination of a substance P-derived peptide (FGLM-NH2) and insulin-like growth factor-1. Diabetologia 46, 839-842

72S. Movafagh (2006) Neuropeptide Y induces migration, proliferation, and tube formation of endothelial cells bimodally via Y1, Y2, and Y5 receptors. The FASEB Journal 20, 1924-1926

73A.J. Ekstrand (2003) Deletion of neuropeptide Y (NPY) 2 receptor in mice results in blockage of NPY-induced angiogenesis and delayed wound healing. Proceedings of the National Academy of Sciences of the United States of America 100, 6033-6038

74L.E. Kuo , K. Abe and Z. Zukowska (2007) Stress, NPY and vascular remodeling: Implications for stress-related diseases. Peptides 28, 435-440

76Z. Zukowska , D.S. Grant and E.W. Lee (2003) Neuropeptide Y: a novel mechanism for ischemic angiogenesis. Trends in Cardiovascular Medicine 13, 86-92

77T. Hokfelt (1975) Experimental immunohistochemical studies on the localization and distribution of substance P in cat primary sensory neurons. Brain Research 100, 235-252

78T. Hokfelt (1975) Substance p: localization in the central nervous system and in some primary sensory neurons. Science 190, 889-890

79C.A. Maggi (2000) The troubled story of tachykinins and neurokinins. Trends in Pharmacological Sciences 21, 173-175

80C.A. Maggi (1995) The mammalian tachykinin receptors. General Pharmacology 26, 911-944

81A.M. Khawaja and D.F. Rogers (1996) Tachykinins: receptor to effector. International Journal of Biochemistry and Cell Biology 28, 721-738

82S. Harrison and P. Geppetti (2001) Substance P. International Journal of Biochemistry and Cell Biology 33, 555-576

83T. Kunt (2000) Serum levels of substance P are decreased in patients with type 1 diabetes. Experimental and Clinical Endocrinology and Diabetes 108, 164-167

84J.E. Olerud (1999) Neutral endopeptidase expression and distribution in human skin and wounds. Journal of Investigative Dermatology 112, 873-881

85G. Bou-Gharios (1995) Expression of ectopeptidases in scleroderma. Annals of the Rheumatic Diseases 54, 111-116

86M. Antezana (2002) Neutral endopeptidase activity is increased in the skin of subjects with diabetic ulcers. Journal of Investigative Dermatology 119, 1400-1404

87M.L. Spenny (2002) Neutral endopeptidase inhibition in diabetic wound repair. Wound Repair and Regeneration 10, 295-301

90J.P. Lai , S.D. Douglas and W.Z. Ho (1998) Human lymphocytes express substance P and its receptor. Journal of Neuroimmunology 86, 80-86

92B.N. Lambrecht (2001) Immunologists getting nervous: neuropeptides, dendritic cells and T cell activation. Respiratory Research 2, 133-138

93B.N. Lambrecht (1999) Endogenously produced substance P contributes to lymphocyte proliferation induced by dendritic cells and direct TCR ligation. European Journal of Immunology 29, 3815-3825

95T.M. O'Connor (2004) The role of substance P in inflammatory disease. Journal of Cellular Physiology 201, 167-180

97A.V. Delgado , A.T. McManus and J.P. Chambers (2003) Production of tumor necrosis factor-alpha, interleukin 1-beta, interleukin 2, and interleukin 6 by rat leukocyte subpopulations after exposure to substance P. Neuropeptides 37, 355-361

98W.L. Matis , R.M. Lavker and G.F. Murphy (1990) Substance P induces the expression of an endothelial-leukocyte adhesion molecule by microvascular endothelium. Journal of Investigative Dermatology 94, 492-495

99R. Vishwanath and R. Mukherjee (1996) Substance P promotes lymphocyte-endothelial cell adhesion preferentially via LFA-1/ICAM-1 interactions. Journal of Neuroimmunology 71, 163-171

101K. Bulut (2008) Sensory neuropeptides and epithelial cell restitution: the relevance of SP- and CGRP-stimulated mast cells. International Journal of Colorectal Disease 23, 535-541

102P. Felderbauer (2007) Substance P induces intestinal wound healing via fibroblasts–evidence for a TGF-beta-dependent effect. International Journal of Colorectal Disease 22, 1475-1480

103H.C. Seegers (2003) Enhancement of angiogenesis by endogenous substance P release and neurokinin-1 receptors during neurogenic inflammation. Journal of Pharmacology and Experimental Therapeutics 306, 8-12

105N.S. Gibran (2002) Diminished neuropeptide levels contribute to the impaired cutaneous healing response associated with diabetes mellitus. Journal of Surgical Research 108, 122-128

106A.G. Blomqvist and H. Herzog (1997) Y-receptor subtypes–how many more? Trends in Neurosciences 20, 294-298

107A. Ericsson (1987) Detection of neuropeptide Y and its mRNA in megakaryocytes: enhanced levels in certain autoimmune mice. Proceedings of the National Academy of Sciences of the United States of America 84, 5585-5589

109D. Larhammar (1996) Structural diversity of receptors for neuropeptide Y, peptide YY and pancreatic polypeptide. Regulatory Peptides 65, 165-174

110A. Franco-Cereceda , J.M. Lundberg and C. Dahlof (1985) Neuropeptide Y and sympathetic control of heart contractility and coronary vascular tone. Acta Physiologica Scandinavica 124, 361-369

111D. Erlinge , J. Brunkwall and L. Edvinsson (1994) Neuropeptide Y stimulates proliferation of human vascular smooth muscle cells: cooperation with noradrenaline and ATP. Regulatory Peptides 50, 259-265

112Z. Zukowska-Grojec (1993) Mitogenic effect of neuropeptide Y in rat vascular smooth muscle cells. Peptides 14, 263-268

113H.M. Frankish (1995) Neuropeptide Y, the hypothalamus, and diabetes: insights into the central control of metabolism. Peptides 16, 757-771

114G. Ahlborg and J.M. Lundberg (1996) Exercise-induced changes in neuropeptide Y, noradrenaline and endothelin-1 levels in young people with type I diabetes. Clinical Physiology 16, 645-655

116D.M. Levy (1989) Depletion of cutaneous nerves and neuropeptides in diabetes mellitus: an immunocytochemical study. Diabetologia 32, 427-433

117J. Kuncova (2005) Heterogenous changes in neuropeptide Y, norepinephrine and epinephrine concentrations in the hearts of diabetic rats. Autonomic Neuroscience 121, 7-15

118D. Andersson (1992) Diminished contractile responses to neuropeptide Y of arteries from diabetic rabbits. Journal of the Autonomic Nervous System 37, 215-222

119J. Wheway , H. Herzog and F. Mackay (2007) NPY and receptors in immune and inflammatory diseases. Current Topics in Medicinal Chemistry 7, 1743-1752

120D.A. Groneberg (2004) Neuropeptide Y (NPY). Pulmonary Pharmacology and Therapeutics 17, 173-180

121S. Bedoui (2003) Relevance of neuropeptide Y for the neuroimmune crosstalk. Journal of Neuroimmunology 134, 1-11

122P. Salo (2007) Neuropeptides regulate expression of matrix molecule, growth factor and inflammatory mediator mRNA in explants of normal and healing medial collateral ligament. Regulatory Peptides 142, 1-6

123G. Ghersi (2001) Critical role of dipeptidyl peptidase IV in neuropeptide Y-mediated endothelial cell migration in response to wounding. Peptides 22, 453-458

125Z. Zukowska-Grojec (1998) Neuropeptide Y: a novel angiogenic factor from the sympathetic nerves and endothelium. Circulation Research 83, 187-195

126J. Kitlinska (2005) Differential effects of neuropeptide Y on the growth and vascularization of neural crest-derived tumors. Cancer Research 65, 1719-1728

127Z. Zukowska (2003) Neuropeptide Y: a new mediator linking sympathetic nerves, blood vessels and immune system? Canadian Journal of Physiology and Pharmacology 81, 89-94

128J. Kitlinska (2002) Neuropeptide Y-induced angiogenesis in aging. Peptides 23, 71-77

129D. van Rossum , U.K. Hanisch and R. Quirion (1997) Neuroanatomical localization, pharmacological characterization and functions of CGRP, related peptides and their receptors. Neuroscience and Biobehavioral Reviews 21, 649-678

130P. Holzer (1988) Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. Neuroscience 24, 739-768

131C.A. Maggi (1995) Tachykinins and calcitonin gene-related peptide (CGRP) as co-transmitters released from peripheral endings of sensory nerves. Progress in Neurobiology 45, 1-98

132S. Russwurm (2001) Procalcitonin and CGRP-1 mrna expression in various human tissues. Shock 16, 109-112

133D.L. Hay , D.R. Poyner and R. Quirion (2008) International Union of Pharmacology. LXIX. Status of the calcitonin gene-related peptide subtype 2 receptor. Pharmacological Reviews 60, 143-145

135M. Dux (2007) Loss of capsaicin-induced meningeal neurogenic sensory vasodilatation in diabetic rats. Neuroscience 150, 194-201

136E. Adeghate (2006) Pattern of distribution of calcitonin gene-related Peptide in the dorsal root ganglion of animal models of diabetes mellitus. Annals of the New York Academy of Sciences 1084, 296-303

139M. Sheykhzade (2000) The effect of long-term streptozotocin-induced diabetes on contractile and relaxation responses of coronary arteries: selective attenuation of CGRP-induced relaxations. British Journal of Pharmacology 129, 1212-1218

140M. Chottova Dvorakova (2005) Cardiomyopathy in streptozotocin-induced diabetes involves intra-axonal accumulation of calcitonin gene-related peptide and altered expression of its receptor in rats. Neuroscience 134, 51-58

141M.A. Yorek (2004) Sensory nerve innervation of epineurial arterioles of the sciatic nerve containing calcitonin gene-related peptide: effect of streptozotocin-induced diabetes. Experimental Diabesity Research 5, 187-193

142R. Ambalavanar (2006) Muscle inflammation induces a rapid increase in calcitonin gene-related peptide (CGRP) mRNA that temporally relates to CGRP immunoreactivity and nociceptive behavior. Neuroscience 143, 875-884

143R. Ambalavanar (2006) Deep tissue inflammation upregulates neuropeptides and evokes nociceptive behaviors which are modulated by a neuropeptide antagonist. Pain 120, 53-68

144C.L. Hu , J.Z. Xiang and F.F. Hu (2008) Vanilloid receptor TRPV1, sensory C-fibers, and activation of adventitial mast cells A novel mechanism involved in adventitial inflammation. Medical Hypotheses 71, 102-103

145P. Linscheid (2004) Expression and secretion of procalcitonin and calcitonin gene-related peptide by adherent monocytes and by macrophage-activated adipocytes. Critical Care Medicine 32, 1715-1721

146P. Linscheid (2005) Autocrine/paracrine role of inflammation-mediated calcitonin gene-related peptide and adrenomedullin expression in human adipose tissue. Endocrinology 146, 2699-2708

147A. Dallos (2006) Effects of the neuropeptides substance P, calcitonin gene-related peptide, vasoactive intestinal polypeptide and galanin on the production of nerve growth factor and inflammatory cytokines in cultured human keratinocytes. Neuropeptides 40, 251-263

149C.A. Foster (1992) Calcitonin gene-related peptide is chemotactic for human T lymphocytes. Annals of the New York Academy of Sciences 657, 397-404

150J.S. Zhang (2006) Regulatory peptides modulate adhesion of polymorphonuclear leukocytes to bronchial epithelial cells through regulation of interleukins, ICAM-1 and NF-kappaB/IkappaB. Acta Biochimica et Biophysica Sinica 38, 119-128

151M.T. Tran (2000) Calcitonin gene-related peptide induces IL-8 synthesis in human corneal epithelial cells. Journal of Immunology 164, 4307-4312

152M. Yamaguchi (2004) Neuropeptides stimulate production of interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha in human dental pulp cells. Inflammation Research 53, 199-204

153R. Yaraee (2003) Neuropeptides (SP and CGRP) augment pro-inflammatory cytokine production in HSV-infected macrophages. International Immunopharmacology 3, 1883-1887

154M. Toda (2008) Roles of calcitonin gene-related peptide in facilitation of wound healing and angiogenesis. Biomedicine and Pharmacotherapy 62, 352-359

155A. Haegerstrand (1990) Calcitonin gene-related peptide stimulates proliferation of human endothelial cells. Proceedings of the National Academy of Sciences of the United States of America 87, 3299-3303

156D. Richard , Q. Huang and E. Timofeeva (2000) The corticotropin-releasing hormone system in the regulation of energy balance in obesity. International Journal of Obesity and Related Metabolic Disorders 24 Suppl 2, S36-39

157S.M. Baigent (2001) Peripheral corticotropin-releasing hormone and urocortin in the control of the immune response. Peptides 22, 809-820

158K.M. Carlin , W.W. Vale and T.L. Bale (2006) Vital functions of corticotropin-releasing factor (CRF) pathways in maintenance and regulation of energy homeostasis. Proceedings of the National Academy of Sciences of the United States of America 103, 3462-3467

159M.H. Perrin and W.W. Vale (1999) Corticotropin releasing factor receptors and their ligand family. Annals of the New York Academy of Sciences 885, 312-328

160I. Chiodini (2005) Association of subclinical hypercortisolism with type 2 diabetes mellitus: a case-control study in hospitalized patients. European Journal of Endocrinology 153, 837-844

161L. Ghizzoni (1993) Adrenal steroid and adrenocorticotropin responses to human corticotropin-releasing hormone stimulation test in adolescents with type I diabetes mellitus. Metabolism 42, 1141-1145

162M.S. Roy (1993) The ovine corticotropin-releasing hormone-stimulation test in type I diabetic patients and controls: suggestion of mild chronic hypercortisolism. Metabolism 42, 696-700

163O. Chan (2002) Hyperactivation of the hypothalamo-pituitary-adrenocortical axis in streptozotocin-diabetes is associated with reduced stress responsiveness and decreased pituitary and adrenal sensitivity. Endocrinology 143, 1761-1768

164O. Chan (2005) Hyperglycemia does not increase basal hypothalamo-pituitary-adrenal activity in diabetes but it does impair the HPA response to insulin-induced hypoglycemia. American Journal of Physiology – Regulatory, Integrative and Comparative Physiology 289, R235-246

165O. Chan (2002) Diabetes impairs hypothalamo-pituitary-adrenal (HPA) responses to hypoglycemia, and insulin treatment normalizes HPA but not epinephrine responses. Diabetes 51, 1681-1689

166A.V. Turnbull and C.L. Rivier (1999) Sprague-Dawley rats obtained from different vendors exhibit distinct adrenocorticotropin responses to inflammatory stimuli. Neuroendocrinology 70, 186-195

167N. Lozovaya and A.D. Miller (2003) Chemical neuroimmunology: health in a nutshell bidirectional communication between immune and stress (limbic-hypothalamic-pituitary-adrenal) systems. Chembiochem 4, 466-484

169I.J. Elenkov (1999) Stress, corticotropin-releasing hormone, glucocorticoids, and the immune/inflammatory response: acute and chronic effects. Annals of the New York Academy of Sciences 876, 1-11; discussion 11–13

170I.J. Elenkov and G.P. Chrousos (1999) Stress Hormones, Th1/Th2 patterns, Pro/Anti-inflammatory Cytokines and Susceptibility to Disease. Trends in Endocrinology and Metabolism 10, 359-368

171E.L. Webster , I.J. Elenkov and G.P. Chrousos (1997) Corticotropin-releasing hormone acts on immune cells to elicit pro-inflammatory responses. Molecular Psychiatry 2, 345-346

172L. Monney (2002) Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature 415, 536-541

173D.H. Brown and B.S. Zwilling (1994) Activation of the hypothalamic-pituitary-adrenal axis differentially affects the anti-mycobacterial activity of macrophages from BCG-resistant and susceptible mice. Journal of Neuroimmunology 53, 181-187

174J.F. Sheridan (1998) Stress-induced neuroendocrine modulation of viral pathogenesis and immunity. Annals of the New York Academy of Sciences 840, 803-808

175E.L. Webster (1998) Corticotropin-releasing hormone and inflammation. Annals of the New York Academy of Sciences 840, 21-32

176K. Karalis (1997) CRH and the immune system. Journal of Neuroimmunology 72, 131-136

177T.C. Theoharides (1998) Corticotropin-releasing hormone induces skin mast cell degranulation and increased vascular permeability, a possible explanation for its proinflammatory effects. Endocrinology 139, 403-413

178K. Karalis (1991) Autocrine or paracrine inflammatory actions of corticotropin-releasing hormone in vivo. Science 254, 421-423

180E.R. Glasper and A.C. Devries (2005) Social structure influences effects of pair-housing on wound healing. Brain, Behavior, and Immunity 19, 61-68

181C.E. Detillion (2004) Social facilitation of wound healing. Psychoneuroendocrinology 29, 1004-1011

182N.H. Kalin (2006) Stress decreases, while central nucleus amygdala lesions increase, IL-8 and MIP-1alpha gene expression during tissue healing in non-human primates. Brain, Behavior, and Immunity 20, 564-568

183C.C. Head (2006) Androstenediol reduces the anti-inflammatory effects of restraint stress during wound healing. Brain, Behavior, and Immunity 20, 590-596

184A.M. Mercado (2002) Altered kinetics of IL-1 alpha, IL-1 beta, and KGF-1 gene expression in early wounds of restrained mice. Brain, Behavior, and Immunity 16, 150-162

185I.G. Rojas (2002) Stress-induced susceptibility to bacterial infection during cutaneous wound healing. Brain, Behavior, and Immunity 16, 74-84

186I. Gantz and T.M. Fong (2003) The melanocortin system. American Journal of Physiology – Endocrinology and Metabolism 284, E468-474

187N.G. Seidah (1999) The subtilisin/kexin family of precursor convertases. Emphasis on PC1, PC2/7B2, POMC and the novel enzyme SKI-1. Annals of the New York Academy of Sciences 885, 57-74

188A.J. Thody (1983) MSH peptides are present in mammalian skin. Peptides 4, 813-816

190J.E. Mazurkiewicz , D. Corliss and A. Slominski (2000) Spatiotemporal expression, distribution, and processing of POMC and POMC-derived peptides in murine skin. Journal of Histochemistry and Cytochemistry 48, 905-914

191M. Bohm (2006) Melanocortin receptor ligands: new horizons for skin biology and clinical dermatology. Journal of Investigative Dermatology 126, 1966-1975

193U. Hochgeschwender (2003) Altered glucose homeostasis in proopiomelanocortin-null mouse mutants lacking central and peripheral melanocortin. Endocrinology 144, 5194-5202

194W. Fan (2000) The central melanocortin system can directly regulate serum insulin levels. Endocrinology 141, 3072-3079

195M. Lee (2007) Transgenic MSH overexpression attenuates the metabolic effects of a high-fat diet. American Journal of Physiology – Endocrinology and Metabolism 293, E121-131

197P.J. Havel (2000) Effects of streptozotocin-induced diabetes and insulin treatment on the hypothalamic melanocortin system and muscle uncoupling protein 3 expression in rats. Diabetes 49, 244-252

200N. Rajora (1997) alpha-MSH modulates experimental inflammatory bowel disease. Peptides 18, 381-385

201A. Catania (1999) alpha-MSH in systemic inflammation. Central and peripheral actions. Annals of the New York Academy of Sciences 885, 183-187

203A. Catania (2004) Targeting melanocortin receptors as a novel strategy to control inflammation. Pharmacological Reviews 56, 1-29

204M. Bohm (1999) Alpha-melanocyte-stimulating hormone modulates activation of NF-kappa B and AP-1 and secretion of interleukin-8 in human dermal fibroblasts. Annals of the New York Academy of Sciences 885, 277-286

207A. Catania (2000) Plasma concentrations and anti-L-cytokine effects of alpha-melanocyte stimulating hormone in septic patients. Critical Care Medicine 28, 1403-1407

208R.A. Star (1995) Evidence of autocrine modulation of macrophage nitric oxide synthase by alpha-melanocyte-stimulating hormone. Proceedings of the National Academy of Sciences of the United States of America 92, 8016-8020

209I. Mandrika , R. Muceniece and J.E. Wikberg (2001) Effects of melanocortin peptides on lipopolysaccharide/interferon-gamma-induced NF-kappaB DNA binding and nitric oxide production in macrophage-like RAW 264.7 cells: evidence for dual mechanisms of action. Biochemical Pharmacology 61, 613-621

210D.H. Kalden (1999) Mechanisms of the antiinflammatory effects of alpha-MSH. Role of transcription factor NF-kappa B and adhesion molecule expression. Annals of the New York Academy of Sciences 885, 254-261

212P. Redondo (1998) Alpha-MSH regulates interleukin-10 expression by human keratinocytes. Archives of Dermatological Research 290, 425-428

213V. Bonfiglio (2006) Effects of the COOH-terminal tripeptide alpha-MSH(11–13) on corneal epithelial wound healing: role of nitric oxide. Experimental Eye Research 83, 1366-1372

214B.M. Evers (2006) Neurotensin and growth of normal and neoplastic tissues. Peptides 27, 2424-2433

215K.J. Gross and C. Pothoulakis (2007) Role of neuropeptides in inflammatory bowel disease. Inflammatory Bowel Diseases 13, 918-932

218M. Berelowitz and L.A. Frohman (1982) The role of neurotensin in the regulation of carbohydrate metabolism and in diabetes. Annals of the New York Academy of Sciences 400, 150-159

219M.H. Fernstrom (1981) Immunoreactive neurotensin levels in pancreas: elevation in diabetic rats and mice. Metabolism 30, 853-855

220M. El-Salhy (1998) Neuroendocrine peptides of the gastrointestinal tract of an animal model of human type 2 diabetes mellitus. Acta Diabetologica 35, 194-198

221F.J. Service (1986) Neurotensin in diabetes and obesity. Regulatory Peptides 14, 85-92

222R. Goldman (1982) Enhancement of phagocytosis by neurotensin, a newly found biological activity of the neuropeptide. Advances in Experimental Medicine and Biology 155, 133-141

227W. Hartschuh , E. Weihe and M. Reinecke (1983) Peptidergic (neurotensin, VIP, substance P) nerve fibres in the skin. Immunohistochemical evidence of an involvement of neuropeptides in nociception, pruritus and inflammation. British Journal of Dermatology 109 Suppl 25, 14-17

228J. Donelan (2006) Corticotropin-releasing hormone induces skin vascular permeability through a neurotensin-dependent process. Proceedings of the National Academy of Sciences of the United States of America 103, 7759-7764

229D. Zhao (2005) Neurotensin stimulates interleukin-8 expression through modulation of I kappa B alpha phosphorylation and p65 transcriptional activity: involvement of protein kinase C alpha. Molecular Pharmacology 67, 2025-2031

230D. Zhao (2003) Neurotensin stimulates IL-8 expression in human colonic epithelial cells through Rho GTPase-mediated NF-kappa B pathways. American Journal of Physiology – Cell Physiology 284, C1397-1404

231P. Brun (2005) Neuropeptide neurotensin stimulates intestinal wound healing following chronic intestinal inflammation. American Journal of Physiology – Gastrointestinal and Liver Physiology 288, G621-629

233T.L. Dinh and A. Veves (2006) Treatment of diabetic ulcers. Dermatologic Therapy 19, 348-355

234D.L. Steed (2006) Guidelines for the treatment of diabetic ulcers. Wound Repair and Regeneration 14, 680-692

236A.R. Denet , R. Vanbever and V. Preat (2004) Skin electroporation for transdermal and topical delivery. Advanced Drug Delivery Reviews 56, 659-674

237R. Vanbever and V.V. Preat (1999) In vivo efficacy and safety of skin electroporation Advanced Drug Delivery Reviews 35, 77-88

238P.Y. Lee , S. Chesnoy and L. Huang (2004) Electroporatic delivery of TGF-beta1 gene works synergistically with electric therapy to enhance diabetic wound healing in db/db mice. Journal of Investigative Dermatology 123, 791-798

239M.P. Lin (2006) Delivery of plasmid DNA expression vector for keratinocyte growth factor-1 using electroporation to improve cutaneous wound healing in a septic rat model. Wound Repair and Regeneration 14, 618-624

240A. Gohshi (1998) Changes in adrenocorticotropic hormone (ACTH) release from the cultured anterior pituitary cells of streptozotocin-induced diabetic rats. Biological & Pharmaceutical Bulletin 21, 795-799

R. Blakytny and E Jude (2006) The molecular biology of chronic wounds and delayed healing in diabetes. Diabetic Medicine 23, 594-608

A. Vinik (2006) Diabetic neuropathies: clinical manifestations and current treatment options. Nature Clinical Practice Endocrinology & Metabolism 2, 269-281

A. Veves , J.M. Giurini and F.W. LoGerfo (2002) The Diabetic Foot: Medical and Surgical Management, Humana Press, Totowa, NJ, USA

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Expert Reviews in Molecular Medicine
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