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Non-invasive molecular biomarkers for predicting outcomes of micro-TESE in patients with idiopathic non-obstructive azoospermia

Published online by Cambridge University Press:  06 June 2022

Dongdong Tang Open the ORCID record for Dongdong Tang [Opens in a new window] ,
Kuokuo Li ,
Xiaojin He Open the ORCID record for Xiaojin He [Opens in a new window] ,
Yan Zhang  and
Yunxia Cao
Dongdong Tang
Affiliation:
Department of Obstetrics and Gynecology, Reproductive Medicine Center, The First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei 230022, Anhui, China NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), No 81 Meishan Road, Hefei 230032, Anhui, China Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, No 81 Meishan Road, Hefei 230032, Anhui, China
Kuokuo Li
Affiliation:
Department of Obstetrics and Gynecology, Reproductive Medicine Center, The First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei 230022, Anhui, China NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), No 81 Meishan Road, Hefei 230032, Anhui, China Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, No 81 Meishan Road, Hefei 230032, Anhui, China
Xiaojin He*
Affiliation:
Department of Obstetrics and Gynecology, Reproductive Medicine Center, The First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei 230022, Anhui, China NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), No 81 Meishan Road, Hefei 230032, Anhui, China Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, No 81 Meishan Road, Hefei 230032, Anhui, China
Yan Zhang*
Affiliation:
Department of Clinical Laboratory, Renmin Hospital of Wuhan University, WuHan 430060, Hubei, China
Yunxia Cao*
Affiliation:
Department of Obstetrics and Gynecology, Reproductive Medicine Center, The First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei 230022, Anhui, China NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), No 81 Meishan Road, Hefei 230032, Anhui, China Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, No 81 Meishan Road, Hefei 230032, Anhui, China
*
Author for correspondence: Yunxia Cao, E-mail: caoyunxia6@126.com; Yan Zhang, E-mail: peneyyan@mail.ustc.edu.cn; Xiaojin He, E-mail: hxj0117@126.com
Author for correspondence: Yunxia Cao, E-mail: caoyunxia6@126.com; Yan Zhang, E-mail: peneyyan@mail.ustc.edu.cn; Xiaojin He, E-mail: hxj0117@126.com
Author for correspondence: Yunxia Cao, E-mail: caoyunxia6@126.com; Yan Zhang, E-mail: peneyyan@mail.ustc.edu.cn; Xiaojin He, E-mail: hxj0117@126.com
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Abstract

Non-obstructive azoospermia (NOA), the most severe type of male infertility, affects approximately 1% of men worldwide. However, the aetiology of most NOA cases is not definite, that is defined as idiopathic NOA (INOA), posing a clinical conundrum worldwide. Most of these patients must receive donor sperm treatment until the emergence of microdissection testicular sperm extraction (micro-TESE). Although this procedure has recently become a promising treatment for INOA, the low sperm retrieval rate and testicular trauma have prompted us to explore appropriate non-invasive molecular biomarkers to predict the outcomes of sperm recovery preoperatively. Previous studies have identified a spectrum of biomarkers to address this challenging issue at various levels in different tissues, such as DNAs, RNAs, protein and steroid levels in the blood and seminal fluid. To better understand and assess the predictive values of diverse molecular biomarkers from different tissues on the outcome of sperm retrieval by micro-TESE in patients with INOA, we summarised recent findings and discussed the potential applications of these methods. The ultimate goal of this study was to provide references for further studies and clinical management.

Keywords

Azoospermiaidiopathicmale infertilitymicro-TESEmolecular biomarkersnon-obstructiveoutcome
Type
Review
Information
Expert Reviews in Molecular Medicine , Volume 24 , 2022 , e22
Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press

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Footnotes

*

These authors contributed equally to this work.

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