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Reduced melatonin levels may facilitate glioblastoma initiation in the subventricular zone

Published online by Cambridge University Press:  16 May 2022

Majid Ghareghani Open the ORCID record for Majid Ghareghani [Opens in a new window] ,
Kazem Zibara ,
Russel J. Reiter  and
Serge Rivest Open the ORCID record for Serge Rivest [Opens in a new window]
Majid Ghareghani
Affiliation:
Neuroscience Laboratory, CHU de Québec Research Centre, Department of Molecular Medicine, Faculty of Medicine, Laval University, Québec City, Québec G1V 4G2, Canada
Kazem Zibara
Affiliation:
PRASE and Biology Department, Faculty of Sciences – I, Lebanese University, Beirut, Lebanon
Russel J. Reiter
Affiliation:
Department of Cell Systems and Anatomy, UT Health, Long School of Medicine, San Antonio, TX, USA
Serge Rivest*
Affiliation:
Neuroscience Laboratory, CHU de Québec Research Centre, Department of Molecular Medicine, Faculty of Medicine, Laval University, Québec City, Québec G1V 4G2, Canada
*
Author for correspondence: Serge Rivest, E-mail: serge.rivest@crchudequebec.ulaval.ca
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Abstract

There is increasing evidence that glioblastoma, a highly aggressive brain tumour, originates from a neural stem cell (NSC) located in the subventricular zone (SVZ) of the lateral cerebral ventricle. Using the most advanced in vivo imaging techniques, Gengatharan and colleagues recently identified a day/night difference in the adult SVZ-NSC division. They reported that the circadian melatonin rhythm and its receptor control the day/night difference in NSC division with high mitotic activity during the day and low activity at night. Expression of melatonin and its receptor diminishes during ageing, which eliminates the regulatory effect of melatonin on NSC mitosis. Moreover, the circadian melatonin rhythm is dampened by light-at-night with the potential of altering the circadian mitotic cycle of NSC in the SVZ. Also, men with a lower melatonin amplitude than women exhibit a 60% higher rate of glioblastoma incidence. Given that ageing contributes significantly to glioblastoma initiation and progression, we suggest that the decline in circadian melatonin synthesis and release as well as its receptors in the SVZ, which also diminish with an ageing act in concert with other factors to facilitate glioblastoma initiation and growth.

Keywords

Cancerglioblastomalightmelatoninneural stem cells
Type
Review
Information
Expert Reviews in Molecular Medicine , Volume 24 , 2022 , e24
Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press

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