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    Tan, Jie Liu, Ai Ping Sun, Chao Bai, Yun Fei and Lv, Fuzhen 2014. Association of ADAM33 gene polymorphisms with COPD in the Mongolian population of China. Annals of Human Biology, Vol. 41, Issue. 1, p. 9.

    Lương, Khanh vinh quốc and Hoàng Nguyễn, Lan Thi 2012. The role of vitamin D in asthma. Pulmonary Pharmacology & Therapeutics, Vol. 25, Issue. 2, p. 137.

    2009. GEMA (Guía española del manejo del asma). Archivos de Bronconeumología, Vol. 45, p. 2.

    Bourdin, A. Chanez, P. Chiron, R. Bousquet, J. Demoly, P. and Godard, P. 2006. Asthme bronchique. EMC - Pneumologie, Vol. 3, Issue. 1, p. 1.

    Aronica, Mark A and Vogel, Nicola 2005. Pathogens and immunologic memory in asthma: what have we learned?. Expert Review of Clinical Immunology, Vol. 1, Issue. 4, p. 589.

    Demoly, P. Godard, P. and Bousquet, J. 2005. Une synthèse sur l'épidémiologie de l'asthme. Revue Française d'Allergologie et d'Immunologie Clinique, Vol. 45, Issue. 6, p. 464.


The discovery and role of ADAM33, a new candidate gene for asthma

  • John W. Holloway (a1), Tim P. Keith (a2), Donna E. Davies (a3), Robert Powell (a3), Hans-Michael Haitchi (a3) and Stephen T. Holgate (a3)
  • DOI:
  • Published online: 01 August 2004

Asthma is a complex disorder in which major genetic and environmental factors interact to initiate the disease and propagate it as a chronic relapsing disorder. Until recently, genetic factors implicated in the disease pathogenesis have been restricted to variants in known molecules involved in the inflammatory or remodelling pathways. This review discusses evidence for a new susceptibility gene for asthma, ADAM33, which was identified by positional cloning and shown to be selectively expressed in mesenchymal but not immune or inflammatory cells. ADAM33 belongs to a family of membrane–anchored metalloproteinases that also have fusagenic, adhesion and intracellular signalling properties. ADAM33 might play a key role in predisposing to the reduced lung function characteristic of asthma, possibly by influencing airway wall remodelling.

Corresponding author
Allergy and Inflammation Research, Infection, Inflammation and Repair Research Division, School of Medicine, University of Southampton, D level Centre Block (MP810), Southampton General Hospital, Southampton, SO16 6YD, UK. Tel: +44 (0)23 8079 6960; Fax: +44 (0)23 8070 1771E-mail:
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Expert Reviews in Molecular Medicine
  • ISSN: -
  • EISSN: 1462-3994
  • URL: /core/journals/expert-reviews-in-molecular-medicine
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