2The concise Oxford dictionary of current English. 9th ed. Oxford: Clarendon Press; 1995.
3Almeida, TF, Roizenblatt, S, Tufik, S. Afferent pain pathways: a neuroanatomical review. Brain Res 2004; 1000: 40–56.
4Anand, KJ, Carr, DB. The neuroanatomy, neurophysiology, and neurochemistry of pain, stress, and analgesia in newborns and children. Pediatr Clin North Am 1989; 36: 795–22.
5Anand, KJ, Hickey, PR. Pain and its effects in the human neonate and fetus. N Engl J Med 1987; 317: 1321–29.
6Fitzgerald, M. Development of pain mechanisms. Br Med Bull 1991; 47: 667–75.
7Okado, N. Onset of synapse formation in the human spinal cord. J Comp Neurol 1981; 201: 211–19.
8Fitzgerald, M. The development of nociceptive circuits. Nat Rev Neurosci 2005; 6: 507–20.
9Kostovic, I, Goldman-Rakic, PS. Transient cholinesterase staining in the mediodorsal nucleus of the thalamus and its connections in the developing human and monkey brain. J Comp Neurol 1983; 219: 431–47.
10Lee, SJ, Ralston, HJ, Drey, EA, Partridge, JC, Rosen, MA. Fetal pain: a systematic multidisciplinary review of the evidence. JAMA 2005; 294: 947–54.
11Brooks, JC, Zambreanu, L, Godinez, A, Craig, AD, Tracey, I. Somatotopic organisation of the human insula to painful heat studied with high resolution functional imaging. Neuroimage 2005; 27: 201–209.
12Craig, AD. Interoception: the sense of the physiological condition of the body. Curr Opin Neurobiol 2003; 13: 500–505.
13Nandi, D, Aziz, T, Carter, H, Stein, J. Thalamic field potentials in chronic central pain treated by periventricular gray stimulation – a series of eight cases. Pain 2003; 101: 97–107.
14Nandi, D, Liu, X, Joint, C, Stein, J, Aziz, T. Thalamic field potentials during deep brain stimulation of periventricular gray in chronic pain. Pain 2002; 97: 47–51.
15White, MC, Wolf, AR. Pain and stress in the human fetus. Best Pract Res Clin Anaesthesiol 2004; 18: 205–20.
16Lowery, CL, Hardman, MP, Manning, N, Hall, RW, Anand, KJ. Neurodevelopmental changes of fetal pain. Semin Perinatol 2007; 31: 275–82.
17Benatar, D, Benatar, M. A pain in the fetus: toward ending confusion about fetal pain. Bioethics 2001; 15: 57–76.
18van de, Velde, Jani, J, De Buck, F, Deprest, J. Fetal pain perception and pain management. Semin Fetal Neonatal Med 2006; 11: 232–36.
19Torres, F, Anderson, C. The normal EEG of the human newborn. J Clin Neurophysiol 1985; 2: 89–103.
20Mellor, DJ, Diesch, TJ, Gunn, AJ, Bennet, L. The importance of ‘awareness’ for understanding fetal pain. Brain Res Brain Res Rev 2005; 49: 455–71.
21Giannakoulopoulos, X, Sepulveda, W, Kourtis, P, Glover, V, Fisk, NM. Fetal plasma cortisol and beta-endorphin response to intrauterine needling. Lancet 1994; 344: 77–81.
22Giannakoulopoulos, X, Teixeira, J, Fisk, N, Glover, V. Human fetal and maternal noradrenaline responses to invasive procedures. Pediatr Res 1999; 45: 494–99.
23Gitau, R, Fisk, NM, Teixeira, JM, Cameron, A, Glover, V. Fetal hypothalamic-pituitary-adrenal stress responses to invasive procedures are independent of maternal responses. J Clin Endocrinol Metab 2001; 86: 104–109.
24Gitau, R, Fisk, NM, Glover, V. Human fetal and maternal corticotrophin releasing hormone responses to acute stress. Arch Dis Child Fetal Neonatal Ed 2004; 89: F29–F32.
25Derbyshire, SW. Locating the beginnings of pain. Bioethics 1999; 13: 1–31.
26Derbyshire, SW, Glover, V. The fetus does not feel pain. Conscience 2004; 25: 32–35.
27Teixeira, J, Fogliani, R, Giannakoulopoulos, X, Glover, V, Fisk, NM. Fetal haemodynamic stress response to invasive procedures. Lancet 1996; 347: 624.
28Vries, JI, Visser, GH, Prechtl, HF. The emergence of fetal behaviour. I. Qualitative aspects. Early Hum Dev 1982; 7: 301–22.
29de Vries, JIP, Visser, GHA, Prechtl, HFR. Fetal motility in the first half of pregnancy. In: Prechtl, HFR, editor. Continuity of neural functions from prenatal to postnatal life. Philadelphia: Lippincott; 1984; 46–64.
30Andrews, K, Fitzgerald, M. The cutaneous withdrawal reflex in human neonates: sensitization, receptive fields, and the effects of contralateral stimulation. Pain 1994; 56: 95–101.
31Burton, IF, Derbyshire, AJ. Sleeping fit caused by excruciating pain in an infant. AMA J Dis Child 1958; 95: 258–60.
32Marshall, RE, SWMABS. Circumcision I. Effects upon newborn behavior. Inf Behav Dev 1980; 3: 1–14.
33Fitzgerald, M, Millard, C, McIntosh, N. Cutaneous hypersensitivity following peripheral tissue damage in newborn infants and its reversal with topical anaesthesia. Pain 1989; 39: 31–36.
34Johnston, CC, Stevens, BJ. Experience in a neonatal intensive care unit affects pain response. Pediatrics 1996; 98: 925–30.
35Craig, KD, Whitfield, MF, Grunau, RV, Linton, J, Hadjistavropoulos, HD. Pain in the preterm neonate: behavioural and physiological indices. Pain 1993; 52: 287–99.
36Andrews, K, Fitzgerald, M. Wound sensitivity as a measure of analgesic effects following surgery in human neonates and infants. Pain 2002; 99: 185–95.
37Andrews, KA, Desai, D, Dhillon, HK, Wilcox, DT, Fitzgerald, M. Abdominal sensitivity in the first year of life: comparison of infants with and without prenatally diagnosed unilateral hydronephrosis. Pain 2002; 100: 35–46.
38Taddio, A, Katz, J, Ilersich, AL, Koren, G. Effect of neonatal circumcision on pain response during subsequent routine vaccination. Lancet 1997; 349: 599–603.
39Reynolds, ML, Fitzgerald, M. Long-term sensory hyperinnervation following neonatal skin wounds. J Comp Neurol 1995; 358: 487–98.
40Leader, LR, Baillie, P, Martin, B, Molteno, C, Wynchank, S. Fetal responses to vibrotactile stimulation, a possible predictor of fetal and neonatal outcome. Aust N Z J Obstet Gynaecol 1984; 24: 251–56.
41Simons, SH, Tibboel, D. Pain perception development and maturation. Semin Fetal Neonatal Med 2006; 11: 227–31.
42Porter, FL, Grunau, RE, Anand, KJ. Long-term effects of pain in infants. J Dev Behav Pediatr 1999; 20: 253–61.
43Strigo, IA, Duncan, GH, Boivin, M, Bushnell, MC. Differentiation of visceral and cutaneous pain in the human brain. J Neurophysiol 2003; 89: 3294–303.
44Humphrey, T. Some correlations between the appearance of fetal reflexes and the development of the nervous system. Prog Brain Res 1964; 4: 93–135.
45Okado, N, Kojima, T. Ontogeny of the central nervous system: neurogenesis, fibre connection, synaptogenesis and myelination in the spinal cord. In: Precht, HFR, editor. Clinics in developmental medicine: continuity of neural functions from prenatal to postnatal life. Philadelphia: Lippincott Co.; 1984; 31–45.
46Konstantinidou, AD, Silos-Santiago, I, Flaris, N, Snider, WD. Development of the primary afferent projection in human spinal cord. J Comp Neurol 1995; 354: 11–2.
47Jones, E. Pain. Int J Psychoanal 1957; 38: 255.
48Grunau, RE, Holsti, L, Whitfield, MF, Ling, E. Are twitches, startles, and body movements pain indicators in extremely low birth weight infants? Clin J Pain 2000; 16: 37–45.
49Ruda, MA, Ling, QD, Hohmann, AG, Peng, YB, Tachibana, T. Altered nociceptive neuronal circuits after neonatal peripheral inflammation. Science 2000; 289: 628–31.
50Penn, AA, Shatz, CJ. Brain waves and brain wiring: the role of endogenous and sensory-driven neural activity in development. Pediatr Res 1999; 45: 447–58.
51Perlman, JM. Neurobehavioral deficits in premature graduates of intensive care–potential medical and neonatal environmental risk factors. Pediatrics 2001; 108: 1339–348.
52Unborn Child Pain Awareness and Prevention Act of 2005. To be codified at Ark Code Ann 20–16, 1101–111. 2005.
53Woman's Right to Know Act. To be codified at Ga Code Ann 31–9A-4. 2005.
54Unborn Child Pain Awareness Act. S51, 109th Cong. 2005.
55Kolenc, AB. Easing abortion's pain: the new fight to help the unborn. America (NY) 2005; 193: 18–21.
56Arthur, J. Fetal pain: a red herring in the abortion debate. Free Inq 2005; 25: 44–47.
57Griffith, S. Fetal death, fetal pain, and the moral standing of a fetus. Public Aff Q 1995; 9: 115–26.
58McLean, S. Old Law, new medicine. River Orams Press 1999.
59Williams, C. Framing the fetus in medical work: rituals and practices. Soc Sci Med 2005; 60: 2085–95.
60Derbyshire, SW. Fetal pain: an infantile debate. Bioethics 2001; 15: 77–84.
61Glover, V, Fisk, NM. Fetal pain: implications for research and practice. Br J Obstet Gynaecol 1999; 106: 881–86.
62Bartlett, LA, Berg, CJ, Shulman, HB, Zane, SB, Green, CA, Whitehead, S, et al. Risk factors for legal induced abortion-related mortality in the United States. Obstet Gynecol 2004; 103: 729–37.
63Henshaw, SK, Finer, LB. The accessibility of abortion services in the United States, 2001. Perspect Sex Reprod Health 2003; 35: 16–24.
64Fisk, NM, Gitau, R, Teixeira, JM, Giannakoulopoulos, X, Cameron, AD, Glover, VA. Effect of direct fetal opioid analgesia on fetal hormonal and hemodynamic stress response to intrauterine needling. Anesthesiology 2001; 95: 828–35.
65Loftus, JR, Hill, H, Cohen, SE. Placental transfer and neonatal effects of epidural sufentanil and fentanyl administered with bupivacaine during labor. Anesthesiology 1995; 83: 300–308.
66Rayburn, W, Rathke, A, Leuschen, MP, Chleborad, J, Weidner, W. Fentanyl citrate analgesia during labor. Am J Obstet Gynecol 1989; 161: 202–206.
67Seeds, JW, Corke, BC, Spielman, FJ. Prevention of fetal movement during invasive procedures with pancuronium bromide. Am J Obstet Gynecol 1986; 155: 818–819.
68Rosen, MA. Anesthesia for procedures involving the fetus. Semin Perinatol 1991; 15: 410–17.
69Rosen, MA. Anesthesia for fetal procedures and surgery. Yonsei Med J 2001; 42: 669–80.
70Cauldwell, CB. Anesthesia for fetal surgery. Anesthesiol Clin North America 2002; 20: 211–26.
71Smith, RP, Gitau, R, Glover, V, Fisk, NM. Pain and stress in the human fetus. Eur J Obstet Gynecol Reprod Biol 2000; 92: 161–65.
72Schwarz, U, Galinkin, JL. Anesthesia for fetal surgery. Semin Pediatr Surg 2003; 12: 196–201.
73Lehmann, KA, Gerhard, A, Horrichs-Haermeyer, G, Grond, S, Zech, D. Postoperative patient-controlled analgesia with sufentanil: analgesic efficacy and minimum effective concentrations. Acta Anaesthesiol Scand 1991; 35: 221–26.
74Strumper, D, Durieux, ME, Gogarten, W, Van, AH, Hartleb, K, Marcus, MA. Fetal plasma concentrations after intraamniotic sufentanil in chronically instrumented pregnant sheep. Anesthesiology 2003; 98: 1400–1406.
75Gregory, GA, Wade, JG, Beihl, DR, Ong, BY, Sitar, DS. Fetal anesthetic requirement (MAC) for halothane. Anesth Analg 1983; 62: 9–14.
76Kan, RE, Hughes, SC, Rosen, MA, Kessin, C, Preston, PG, Lobo, EP. Intravenous remifentanil: placental transfer, maternal and neonatal effects. Anesthesiology 1998; 88: 1467–74.
77van de, Velde, Van Schoubroeck, D, Lewi, LE, Marcus, MA, Jani, JC, Missant, C, et al. Remifentanil for fetal immobilization and maternal sedation during fetoscopic surgery: a randomized, double-blind comparison with diazepam. Anesth Analg 2005; 101: 251–58.
78Szeto, HH, Mann, LI, Bhakthavathsalan, A, Liu, M, Inturrisi, CE. Meperidine pharmacokinetics in the maternal-fetal unit. J Pharmacol Exp Ther 1978; 206: 448–59.
79Myers, LB, Bulich, LA, Hess, P, Miller, NM. Fetal endoscopic surgery: indications and anaesthetic management. Best Pract Res Clin Anaesthesiol 2004; 18: 231–58.