Alcohol was discovered soon after the development of waterproof pots to store and transport water and fruit. Liquids produced by spontaneous fermentation of grains, sugars and fruits were found to enhance pleasure. During the middle ages alchemists discovered that distillation increased this power and thought they had found the elixir of life. Since then almost every culture has used alcohol. Each society has introduced its own restrictions on the availability, exports, imports and consumption of alcoholic beverages within its religious and political structure. Generally, drinking levels which interfere with self-control or result in individual, familial or societal harm are disapproved by all cultures.

Diagnostic ultrasonography has achieved an almost universal role in the practice of obstetrics, due to technological improvements in equipment and the experience acquired by well-trained ultrasonographers. Within the general population, over 3% of children reportedly have major congenital malformations that are life-threatening, require major surgery or have serious cosmetic effects. Many of these malformations can be detected antenatally by obstetric ultrasound. The introduction of high frequency transvaginal ultrasonography is a major development in the area of obstetric ultrasonography. Using this method, fetal anomalies have been successfully identified as early as the first trimester of pregnancy, leading some investigators to advocate routine ultrasound examination during pregnancy in order to screen for fetal anomalies at a gestational age that permits consistently accurate diagnosis and maximizes parental choice.

During intrauterine life the fetus is bathed in amniotic fluid which provides a low resistance space for free movement and a buffer against external trauma. This fluid is produced in early pregnancy largely as a maternal dialysate, then as a fetal transudate. Fetal urine is the most important source of amniotic fluid after 16 weeks gestation. The control of amniotic fluid is complex and poorly understood; it arises from secondary partitioning of water within the fetoplacental extracellular space and reflects fetal fluid balance.

This year marks the 250th anniversary of the discovery by William Hunter of the existence of two distinct circulations within the human placenta. Until relatively recently the placenta has been viewed with “respect” – a passive structure which occasionally elicited fear and anxiety if implanted either too low or too deep. More recently our understanding of perinatal physiology, blood flow regulation and epidemiological data linking prenatal events with adult disease has created renewed interest in the placenta. This review will focus on the regulation of fetal blood flow in the placenta, the possible mechanisms whereby it may be deranged and why this might be relevant to adult disease.