Skip to main content
×
Home
    • Aa
    • Aa

The non-random occurrence of Robertsonian fusion in the house mouse

  • ELODIE GAZAVE (a1), JOSETTE CATALAN (a1), MARIA DA GRAÇA RAMALHINHO (a2), MARIA DA LUZ MATHIAS (a3), ANA CLAUDIA NUNES (a3), DAVID DUMAS (a1), JANICE BRITTON-DAVIDIAN (a1) and JEAN-CHRISTOPHE AUFFRAY (a1)...
Abstract

Chromosomal rearrangements such as Robertsonian (Rb) fusions constitute a major phenomenon in the evolution of genome organization in a wide range of organisms. Although proximate mechanisms for the formation of Rb fusion are now well identified, the evolutionary forces that drive chromosomal evolution remain poorly understood. In the house mouse, numerous chromosomal races occur in nature, each defined by a unique combination of Rb fusions. Among the 106 different Rb fusions that were reported from natural populations, the low involvement of chromosome 19 in Rb fusions is striking, prompting the question of the randomness of chromosomal involvement in Rb fusions. We uncover a significant quadratic relationship between chromosome size and probability of fusing, which has never previously been in this species. It appears that fusions involving chromosome 19 are not particularly infrequent, given the expected low fusion probability associated with the chromosome's size. The results are discussed, assessing selective processes or constraints that may operate on chromosome size.

Copyright
Corresponding author
Tel: +33 4 67 14 47 82. Fax: +33 4 67 14 36 10. e-mail: gazave@isem.univ-montp2.fr
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Genetics Research
  • ISSN: 0016-6723
  • EISSN: 1469-5073
  • URL: /core/journals/genetics-research
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×