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    Lehman, A. L. Nakatsu, Y. Ching, A. Bronson, R. T. Oakey, R. J. Keiper-Hrynko, N. Finger, J. N. Durham-Pierre, D. Horton, D. B. Newton, J. M. Lyon, M. F. and Brilliant, M. H. 1998. A very large protein with diverse functional motifs is deficient in rjs (runty, jerky, sterile) mice. Proceedings of the National Academy of Sciences, Vol. 95, Issue. 16, p. 9436.
    Brilliant, Murray H. 1992. The mouse pink-eyed dilution locus: a model for aspects of Prader-Willi syndrome, Angelman syndrome, and a form of hypomelanosis of Ito. Mammalian Genome, Vol. 3, Issue. 4, p. 187.
    BRILLIANT, MURRAY H. and GONDO, YOICHI 1992. Molecular Characterization of the pun Allele of the Mouse Pink-Eyed Dilution Locus. Pigment Cell Research, Vol. 5, Issue. 5, p. 271.
    Beamer, Wesley G. Wilson, Melba C. and Leiter, Edward H. 1983. The Mouse in Biomedical Research. p. 165.
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The effects of mutant p-alleles on the reproductive system in mice*

  • Roger W. Melvold (a1)
Summary

The p6H, p25H, and pbs alleles at the pink-eyed dilution locus in mice (Mus musculus) cause sterility in males and semi-fertility in females when homozygous, while the pd, pun, p, and + alleles do not reduce fertility. Pituitaries from sterile males had significantly lower proportions of gonadotropic cells than pituitaries from fertile males. Ovaries from semi-fertile females contained large numbers of developing follicles, but no corpora lutea or corpora hemorrhagica were found. The proportion of polyovular follicles in ovaries of semifertile females was abnormally high.

Pituitary gonadotropins appear to be reduced in the sterile genotypes although the lesion cannot be localized. Possible relationships between these and other pleiotropic effects of mutant p-alleles are discussed.

Copyright
COPYRIGHT: © Cambridge University Press 1974
References
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Hollander, W. F., Bryan, J. D. H. & Gowen, J. W. (1960 a). A male sterile pink-eyed mutant type in the mouse. Fertility and Sterility 11, 316.
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Genetics Research
  • ISSN: 0016-6723
  • EISSN: 1469-5073
  • URL: /core/journals/genetics-research
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