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    West, G. B. 2008. Ciba Foundation Symposium - Drug Responses in Man. p. 181.
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Genetical control of the anaphylactoid reaction in rats

  • J. M. Harris (a1), H. Kalmus (a2) and G. B. West (a3)
Extract

1. A recessive autosomal gene, dx, preventing the anaphylactoid reaction has been discovered in a stock of Wistar albino rats from the Agricultural Research Council, Compton.

2. Segregation occurred in the F2 generation derived from crossing pure-bred reactor rats and pure-bred non-reactor rats.

3. Non-reactivity was outbred into non-albino stocks and was shown to segregate independently of the albino gene c and not to be closely linked to the colour genes, P and A.

4. The mutation from Dx to dx may have arisen a few years ago in one of the Wistar colonies before it was split into sub-lines.

5. The dx gene is fixed in several brother-sister mated sub-lines and appears to be in equilibrium with Dx in some less inbred closed-populations.

Copyright
COPYRIGHT: © Cambridge University Press 1963
References
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Grewal, M. S. (1962). The rate of genetic divergence of sublines in the C57BL strain of mice. Genet. Res. 3, 226–237.
Harris, J. M. & West, G. B. (1961). Anaphylaetoid reaction in rats. Nature, Lond., 191, 399–400.
Harris, J. M. & West, G. B. (1963). Rats resistant to the dextran anaphylactoid reaction. Brit. J. Pharmacol. 20, 550–562.
Kalow, W. (1962). Pharmacogenetics. Heredity and the Response to Drugs. Philadelphia: W. B. Saunders Company.
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Genetics Research
  • ISSN: 0016-6723
  • EISSN: 1469-5073
  • URL: /core/journals/genetics-research
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