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    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Eanes, Walter F. Wesley, Cedric and Charlesworth, Brian 1992. Accumulation of P elements in minority inversions in natural populations of Drosophila melanogaster. Genetical Research, Vol. 59, Issue. 01, p. 1.

    MALASPINA, P. PERSICHETTI, F. NOVELLETTO, A. IODICE, C. TERRENATO, L. WOLFE, J. FERRARO, M. and PRANTERA, G. 1990. The human Y chromosome shows a low level of DNA polymorphism. Annals of Human Genetics, Vol. 54, Issue. 4, p. 297.


Insertion-deletion variation at the yellow-achaete-scute region in two natural populations of Drosophila melanogaster

  • Robin N. Beech (a1) and Andrew J. Leigh Brown (a1)
  • DOI:
  • Published online: 01 April 2009

We have surveyed the region of the X chromosome of Drosophila melanogaster which encodes the yellow, achaete and scute genes for restriction map variation. Two natural populations, one from North Carolina, U.S.A. and the other from southern Spain were screened for variation at about 70 restriction sites and for variation due to DNA insertion or deletion events in 120 kilobases of DNA. Mean heterozygosity per nucleotide was estimated to be 0·0024 and 15 large insertions were found in the 49 chromosomes screened. Extensive disequilibrium between polymorphic sites was found across much of the region in the North Carolina population. The frequency of large insertions, which usually correspond to transposable genetic elements, is significantly lower than has been observed in autosomal regions of the genome. This is predicted for X-linked loci by certain models of transposable element evolution, where copy number is restricted by virtue of the recessive deleterious effects of the insertions. Our results appear to support such models. The deficiency of insertions may in this case be enhanced by hitch-hiking effects arising from the high level of disequilibrium.

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J. F. Y. Brookfield (1982). Interspersed, repetitive DNA sequences are unlikely to be parasitic. Journal of Theoretical Biology 94, 281299.

S. Campuzano , L. Carramolino , C. V. Cabrera , M. Ruiz-Gomez , R. Villares , A. Boronat & J. Modellel (1985). Molecular genetics of the achaete-scute gene complex of Drosophila melanogaster. Cell 40, 327338.

A. Economou-Pachnis , M. A. Lohse , A. V. Furano & P. N. Tsichlis (1985). Insertion of long interspersed repeated elements in the Igh (immunoglobulin heavy chain) and Mlvi-2 (molony leukaemia virus integration 2) loci of rats. Proceedings of the National Academy of Sciences, USA. 82, 28572861.

B. Errede , T. S. Cardillo , F. Sherman , E. Dubois , J. Deschamps & J. M. Waine (1980). Mating signals control expression of mutations resulting from insertion of a transposable repetitive element adjacent to diverse yeast genes. Cell 22, 427436.

W. J. Ewens , R. S. Spielman & H. Harris (1981). Estimation of genetic variation at the DNA level from restriction endonuclease data. Proceedings of the National Academy of Sciences, USA. 78, 37483750.

A. P. Feinberg & B. Vogelstein (1984). A technique for radiolabelling DNA restriction endonuclease fragments to a high specific activity. Analytical Biochemistry 132, 613.

A.-M. Frischauf , H. Lehrach , A. Poustka & N. Murray (1983). Lambda replacement vectors carrying poly linker sequences. Journal of Molecular Biology 170, 827842.

M. Gellert (1981). DNA topoisomerases. Annual Review of Biochemistry 50, 879910.

G. B. Golding , C. F. Aquadro & C. H. Langley (1986). Sequence evolution within populations under multiple types of mutation. Proceedings of the National Academy of Sciences, USA83, 427431.

J. B. S. Haldane (1927). A mathematical theory of natural and artificial selection. Part V. Selection and mutation. Proceedings of the Cambridge Philosophical Society 23, 836844.

F. Jimenez & J. A. Campos-Ortega (1979). A region of the Drosophila genome necessary for CNS development Nature 282, 310312.

D. A. Johnson , J. W. Gautsch , R. J. Sportsman & J. H. Elder (1984). Improved technique utilizing non fat dry milk for analysis of proteins and nucleic acids transferred to nitrocellulose. Genetical Analysis Techniques 1, 38.

N. Kleckner (1981). Transposable elements in prokaryotes. Annual Review of Genetics 15, 341404.

A. J. Leigh Brown (1983). Variation at the 87A heat shock locus in Drosophila melanogaster. Proceedings of the National Academy of Sciences, USA80, 53505354.

N. E. Morton (1971). Population genetics and disease control. Social Biology 18, 243251.

S. M. Parkhurst & V. G. Corces (1986). Interactions among the gypsy transposable element and the yellow and suppressor of Hairy-wing loci in Drosophila melanogaster. Molecular and Cellular Biology 6, 4753.

M. J. Simmons & J. F. Crow (1977). Mutations affecting fitness in Drosophila populations. Annual Review of Genetics 11, 4978.

A. Udvardy , P. Schedl , M. Saunder & T.-S. Hsieh (1985). Novel partitioning of DNA cleavage sites for Drosophila topoisomerase II. Cell 40, 933941.

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