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Pedigree analysis for conservation of genetic diversity and purging

  • R. WELLMANN (a1) and I. PFEIFFER (a2)
Summary

We present an approach to describe and evaluate changes in genetic diversity and to calculate bounds for improvement. This pedigree-based analysis was applied to the Kromfohrländer dog (FCI Gr9 Sec10). Pedigrees trace back to the foundation of the breed and were available for 5527 individuals. Based on this dataset the population structure and historical bottlenecks were studied. Distributions of allele frequencies were estimated by Monte Carlo simulation. To monitor changes in mating systems throughout the breeding history, the homozygosity of alleles was compared with their expectations in Hardy–Weinberg equilibrium. Different breeding lines were identified by hierarchical cluster analysis and were characterized by ancestor contributions. Our calculations showed that the founder event in 1945 was followed by two bottlenecks. One was caused by strong selection in a very small population, and the other was triggered by rigorous disease management. The necessary amount of purging that arised due to the bottlenecks was also discussed.

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Corresponding author
*Corresponding author. e-mail: wellmann@mathematik.uni-kassel.de
References
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Awdeh, Z. L. & Alper, C. A. (2005). Mendelian inheritance of polygenic diseases: a hypothetical basis for increasing incidence. Medical Hypotheses 64, 495498.
Awdeh, Z. L., Yunis, E. J., Audeh, M. J., Fici, D., Pugliese, A., Larsen, C. E. & Alper, C. A. (2006). A genetic explanation for the rising incidence of type 1 diabetes, a polygenic disease. Journal of Autoimmunity 3, 174181.
Ballou, J. D. & Lacy, R. C. (1995). Identifying genetically important individuals for management of genetic diversity in captive populations. In Population Management for Survival and Recovery (ed. Ballou, J. D., Gilpin, M. & Foose, T. J.), pp. 76–111. New York: Columbia University Press.
Caballero, A. & Toro, M. A. (2000). Interrelations between effective population size and other pedigree tools for the management of conserved populations. Genetical Research 75, 331343.
Caballero, A. & Toro, M. A. (2002). Analysis of genetic diversity for the management of conserved subdivided populations. Conservation Genetics 3, 289299.
Charlesworth, B. & Charlesworth, D. (1999). The genetic basis of inbreeding depression. Genetical Research 74, 329340.
Cole, J. B., Franke, D. E. & Leighton, E. A. (2004). Population structure of a colony of dog guides. Journal of Animal Science 82, 29062912.
Eklund, J. & Bradford, G. E. (1976). Genetic analysis of a strain of mice plateaued for litter size. Genetics 85, 529542.
Falconer, D. S. (1971). Improvement of litter size in a strain of mice at a selection limit. Genetical Research 17, 215235.
Kimura, M. & Crow, J. F. (1963). On the maximum avoidance of inbreeding. Genetical Research 4, 399415.
Lacy, R. C. (1995). Clarification of genetic terms and their use in the management of captive populations. Zoo Biology 14, 565577.
Leberg, P. L. & Firmin, B. D. (2008). Role of inbreeding depression and purging in captive breeding and restoration programmes. Molecular Ecology 17, 334343.
MacCluer, J. W., VandeBerg, J. L., Read, B. & Ryder, O. A. (1986). Pedigree analysis by computer simulation. Zoo Biology 5, 147160.
Nei, M. (1973). Analysis of gene diversity in subdivided populations. Proceedings of the National Academy of Sciences of the USA 70, 33213323.
Phillips, J. C., Stephenson, B., Hauck, M. & Dillberger, J. (2007). Heritability and segregation analysis of osteosarcoma in the Scottish deerhound. Genomics 90, 354363.
Proschowsky, H. F., Rugbjerg, H. & Ersbøll, A. K. (2003). Mortality of purebred and mixed-breed dogs in Denmark. Preventive veterinary medicine 58, 6374.
Robertson, A. (1952). The effect of inbreeding on the variation due to recessive genes. Genetics 37, 189207.
Templeton, A. R. (1980). The theory of speciation via the founder principle. Genetics 94, 10111038.
Toro, M. A. & Caballero, A. (2005). Characterization and conservation of genetic diversity in subdivided populations. Philosophical Transactions of the Royal Society B 360, 13671378.
Vales-Alonso, J., Fernandez, J., González-Castaño, F. J. & Caballero, A. (2003). A parallel optimization approach for controlling allele diversity in conservation schemes. Mathematical Biosciences 183, 161173.
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Genetics Research
  • ISSN: 0016-6723
  • EISSN: 1469-5073
  • URL: /core/journals/genetics-research
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