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Infection Control & Hospital Epidemiology Infection Control & Hospital Epidemiology

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Smallpox Vaccine: “Non-Take” Responses in Previously Vaccinated Adults

Published online by Cambridge University Press:  02 January 2015

Georgia Thomas ,
Elizabeth Frenzel  and
Hend Hanna
Georgia Thomas*
Affiliation:
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M. D. Anderson Cancer Center, Houston, Texas
Elizabeth Frenzel
Affiliation:
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M. D. Anderson Cancer Center, Houston, Texas
Hend Hanna
Affiliation:
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M. D. Anderson Cancer Center, Houston, Texas
*
Department of Infectious Diseases, Infection Control and Employee Health (Unit 631), The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030
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Abstract

This small, retrospective study of laboratory workers who received smallpox vaccine showed a strong correlation between “non-take” reactions and the presence of prior vaccination scars. Although we cannot exclude technique and vaccine potency as causes, the association we observed may indicate that these workers are displaying residual immunity to smallpox.

Type
Concise Communications
Information
Infection Control & Hospital Epidemiology , Volume 25 , Issue 7 , July 2004 , pp. 613 - 615
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2004

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References

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2.Frey, SE, Couch, RB, Tacket, CO, et al.Clinical responses to undiluted and diluted smallpox vaccine. N Engl J Med 2002;346:1265–1274.CrossRefGoogle ScholarPubMed
3.Neff, JM, Millar, JD, Roberto, RR, Wulff, H. Smallpox vaccination by intradermal jet injection: 3. Evaluation in a well-vaccinated population. Bull World Health Organ 1969;41:771–778.Google Scholar
4.Nyerges, G, Hollos, I, Losonczy, G, Erdos, L, Petras, G. Development of vaccination immunity in hospital personnel revaccinated at three-year intervals. Acta Microbiologica Academiae Scientiarum Hungaricae 1972;19:63–68.Google ScholarPubMed
5.Lane, JM, Mack, TM, Millar, JD. Take rates by double versus single insertions of smallpox vaccine in revaccinees. Public Health Rep 1970;85:928–932.CrossRefGoogle ScholarPubMed
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