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Antimicrobial Activity of Home Disinfectants and Natural Products Against Potential Human Pathogens

  • William A. Rutala (a1) (a2), Susan L. Barbee (a3), Newman C. Aguiar (a3), Mark D. Sobsey (a3) and David J. Weber (a1) (a2) (a4)...
Abstract
Objective:

To assess the efficacy of both natural products (vinegar, baking soda) and common commercial disinfectants (Vesphene Ilse, TBQ, Clorox, Lysol Disinfectant Spray, Lysol Antibacterial Kitchen Cleaner, Mr. Clean Ultra, ethanol) designed for home or institutional use against potential human pathogens, including selected antibiotic-resistant bacteria.

Design:

A quantitative suspension test was used to assess the efficacy of selected disinfectants following exposure times of 30 seconds and 5 minutes. Activity was assessed against Staphylococcus aureus, Salmonella choleraesuis, Escherichia coli 0157:H7, and Pseudomonas aeruginosa. Selected disinfectants were also tested against poliovirus, vancomycin-susceptible and -resistant Enterococcus species, and methicillin-susceptible and -resistant S aureus.

Results:

The following compounds demonstrated excellent antimicrobial activity (>5.6-8.2 log10 reduction) at both exposure times: TBQ, Vesphene, Clorox, ethanol, and Lysol Antibacterial Kitchen Cleaner. Mr. Clean eliminated 4 to >6 logs10 and Lysol Disinfectant ~4 logs10 of pathogenic microorganisms at both exposure times. Vinegar eliminated <3 logs10 of S aureus and E coli, and baking soda <3 logs10 of all test pathogens. All tested chemical disinfectants completely inactivated both antibiotic-resistant and -susceptible bacteria at both exposure times. Only two disinfectants, Clorox and Lysol, demonstrated excellent activity (>3 log10 reduction) against poliovirus.

Conclusions:

A variety of commercial household disinfectants were highly effective against potential bacterial pathogens. The natural products were less effective than commercial household disinfectants. Only Clorox and Lysol disinfectant were effective against poliovirus

Copyright
Corresponding author
′547 Burnett-Womack Bldg, CB 7030, Division of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7030
References
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1.Institute of Medicine. In: Lederberg, J, Shope, RE, Oaks, SC Jr, eds. Emerging Infections: Microbial Threats to Health in the United States. Washington, DC: National Academy Press; 1992.
2.Emori, TG, Gaynes, RP. An overview of nosocomial infections, including the role of the microbiology laboratory. Clin Microbiol Rev 1993;6:428442.
3.Boyce, JM. Methicillin-resistant Staphylococcus aureus in hospitals and long-term care facilities: microbiology, epidemiology, and preventive measures. Infect Control Hosp Epidemiol 1992;13:725737.
4.Mulligan, ME, Murray-Leisure, KA, Ribner, BS, Standiford, HC, John, JF, Korvick, JA, et al. Methicillin-resistant Staphylococcus aureus: a consensus review of the microbiology, pathogenesis, and epidemiology with implications for prevention and management. Am JMed 1993;94:313328.
5.Boyce, JM, Jackson, MM, Pugliese, G, Batt, MD, Fleming, D, Garner, JS, et al. Methicillin-resistant Staphylococcus aureus (MRSA): a briefing for acute care hospitals and nursing facilities, Infect Control Hosp Epidemiol 1994;15:105115.
6.Weber, DJ, Rutala, WA. Role of environmental contamination in the transmission of vancomycin-resistant enterococci. Infect Control Hosp Epidemiol 1997;18:306309.
7.Bonten, MJ, Hayden, MK, Nathan, C, van Voorhis, J, Matushek, M, Slaughter, S, et al. Epidemiology of colonisation of patients and environment with vancomycin-resistant enterococci. Lancet 1996;348:16151619.
8.Samore, MH, Venkataraman, L, DeGirolami, PC, Arbeit, RD, Karchmer, AW. Clinical and molecular epidemiology of sporadic and clustered cases of nosocomial Clostridium difficile diarrhea. Am J Med 1996;100:3240.
9.Fekety, R, Kim, KH, Brown, D, Batts, DH, Cudmore, M, Silva, J. Epidemiology of antibiotic-associated colitis: isolation of Clostridium difficile from the hospital environment. Am JMed 1981;70:906908.
10.Malamou-Ladas, H, O'Farrell, S, Nash, JQ, Tabaqchali, S. Isolation of Clostridium difficile from patients and the environment of hospital wards. J Clin Pathol 1983;36:8892.
11.Kaatz, GW, Gitlin, SD, Schaberg, DRWilson, KH, Kauffman, CA, Seo, SM, et al. Acquisition of Clostridium difficile from the hospital environment. Am J Epidemiol 1988;127:12891294.
12.Laborde, DJ, Weigle, KA, Weber, DJ, Kotch, JB. Effect of fecal contamination on diarrheal illness rates in day-care centers. Am J Epidemiol 1993;138:243255.
13.Ekanem, EE, DuPont, HL, Pickering, LK, Selwyn, BJ, Hawkins, CM. Transmission dynamics of enteric bacteria in day-care centers. Am J Epidemiol 1983;118:562572.
14.Finch, JE, Prince, J, Hawksworth, M. A bacteriologie survey of the domestic environment. J Applied Bacteriol 1978;45:357364.
15.Scott, E, Bloomfield, SF, Barlow, CG. An investigation of microbial contamination in the home. J Hyg Camb 1982;89:279293.
16.Gwaltney, JM Jr, Hendley, JO. Transmission of experimental rhinovirus infection by contaminated surfaces. Am J Epidemiol 1982;116:828833.
17.Ward, RL, Bernstein, DI, Knowlton, DR, Sherwood, JR, Young, EC, Cusack, TM, et al. Prevention of surface-to-human transmission of rotaviruses by treatment with disinfectant spray. J Clin Microbiol 1991;29:19911996.
18.Sattar, SA, Springthorpe, VS. Transmission of viral infections through animate and inanimate surfaces and infection control through chemical disinfection. In: Hurst, DJ, ed. Modeling Disease Transmission and Its Prevention by Disinfection. Cambridge, England: Cambridge University Press; 1996:224257.
19.Scott, E, Bloomfield, SF. The survival and transfer of microbial contamination via cloths, hands and utensils. J Bacteriol 1990;68:271278.
20.Sattar, SA, Jacobsen, H, Springthorpe, VS, Cusack, TM, Rubino, JR. Chemical disinfection to interrupt transfer of rhinovirus type 14 from environmental surfaces to hands. Appl Environ Microbiol 1993;59:15791585.
21.Centers for Disease Control and Prevention. CDC Surveillance Summaries. MMWR 1996;45(SS-5):166.
22.Rutala, WA, Weber, DJ. Environmental issues and nosocomial infections. In: Farber, BF, ed. Infection Control in Intensive Care. New York, NY: Churchill Livingstone; 1987:131171.
23.Griffin, PM, Boyce, TG. Escherichia coli 0157:H7. In: Scheid, WM, Armstrong, D, Hughes, JM, eds. Emerging Infections. Washington, DC: ASM Press; 1998:137145.
24.Whittam, TS, McGraw, EA, Reid, SD. In: Krause, RM, ed. Emerging Infections. San Diego, CA: Academic Press; 1998:163183.
25.Slutsker, L, Villarino, ME, Jarvis, WR, Goulding, J. Foodborne disease prevention in healthcare facilities. In: Bennett, JV, Brachman, PS, eds. Hospital Infections. 4th ed. Philadelphia, PALippincott-Raven; 1998:333337.
26.Chatburn, RL, Kallstrom, TJ, Bajaksouzian, S. A comparison of acetic acid with a quaternary ammonium compound for disinfection of hand-held nebulizers. Respir Care 1988;33:179187.
27.Olson, W, Vesley, D, Bode, M, Dubbel, P, Bauer, T. Hard surface cleaning performance of six alternative household cleaners under laboratory conditions. J Environ Health 1994;56:2731.
28.Bauer, JM, Beronio, CA, Rubino, JR. Antibacterial activity of environmentally “green” alternative products tested in standard antimicrobial tests and a simulated in-use assay. J Environ Health 1995;57:1318.
29.Parnes, CA. Efficacy of sodium hypochlorite bleach and “alternative” products in preventing transfer of bacteria to and from inanimate surfaces. J Environ Health 1997;59:1420.
30.Daschner, F. The hospital and pollution: Role of the hospital epidemiologist in protecting the environment. In: Wenzel, RP, ed. Prevention and Control of Nosocomial Infections. 3rd ed. Baltimore, MD: Williams & Wilkins; 1997:595605.
31.Rutala, WA, Stiegel, MM, Sarubbi, FA, Weber, DJ. Susceptibility of antibiotic-susceptible and antibiotic-resistant hospital bacteria to disinfectants. Infect Control Hosp Epidemiol 1997;18:417421.
32.Anderson, RL, Carr, JH, Bond, WW, Favero, MS. Susceptibility of vancomycin-resistant enterococci to environmental disinfectants. Infect Control Hosp Epidemiol 1997;18:195199.
33.Preventing the spread of vancomycin resistance—a report from the Hospital Infection Control Practices Advisory Committee prepared by the Subcommittee on Prevention and Control of Antimicrobial Resistant Microorganisms in Hospitals; comment period and public meeting— CDC. Notice. Fed Regist 1994;59:2575825763.
34.Garner, JS. Guideline for isolation precautions in hospitals. Infect Control Hosp Epidemiol 1996;17:5380.
35.Occupational Exposure to Bloodborne pathogens—OSHA Final rule. Fed Regist 1991;56:6417564182.
36.Rutala, WA. APIC guideline for selection and use of disinfectants. Am J Infect Control 1996;24:313342.
37.Kotch, JB, Weigle, KA, Weber, DJ, Clifford, RM, Harms, TO, Loda, FA, et al. Evaluation of an hygienic intervention in day-care centers. Pediatrics 1994;94:991994.
38.Sattar, SAJacobsen, H, Rahman, H, Cusack, TM, Rubino, JR. Interruption of rotavirus spread through chemical disinfection. Infect Control Hosp Epidemiol 1994;15:751756.
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Infection Control & Hospital Epidemiology
  • ISSN: 0899-823X
  • EISSN: 1559-6834
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