Skip to main content Accessibility help

Blood Stream Infection in Patients on Venovenous Extracorporeal Membrane Oxygenation for Respiratory Failure

  • Soo Jin Na (a1), Chi Ryang Chung (a1), Hee Jung Choi (a2), Yang Hyun Cho (a3), Jeong Hoon Yang (a1) (a4), Gee Young Suh (a1) (a5) and Kyeongman Jeon (a1) (a5)...


Bloodstream infection (BSI) occurred in 21 of 121 patients (17%) receiving venovenous extracorporeal membrane oxygenation within the median time of 6 days after initiation (interquartile range, 4–19 days). Longer duration of arterial catheterization and more blood transfusions were independently associated with BSI, which is associated with poor clinical outcomes.

Infect Control Hosp Epidemiol 2018;1–4


Corresponding author

Address correspondence to Kyeongman Jeon, MD, PhD, Department of Critical Care Medicine and Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Republic of Korea (


Hide All
1. Schmidt, M, Brechot, N, Hariri, S, et al. Nosocomial infections in adult cardiogenic shock patients supported by venoarterial extracorporeal membrane oxygenation. Clin Infect Dis 2012;55:16331641.
2. Brodie, D, Bacchetta, M. Extracorporeal membrane oxygenation for ARDS in adults. N Engl J Med 2011;365:19051914.
3. Thiagarajan, RR, Barbaro, RP, Rycus, PT, et al. Extracorporeal life support organization registry international report, 2016. ASAIO J 2017;63:6067.
4. Burket, JS, Bartlett, RH, Vander Hyde, K, Chenoweth, CE. Nosocomial infections in adult patients undergoing extracorporeal membrane oxygenation. Clin Infect Dis 1999;28:828833.
5. Kutlesa, M, Santini, M, Krajinovic, V, et al. Nosocomial blood stream infections in patients treated with venovenous extracorporeal membrane oxygenation for acute respiratory distress syndrome. Minerva Anestesiol 2017;83:493501.
6. Grasselli, G, Scaravilli, V, Di Bella, S, et al. Nosocomial infections during extracorporeal membrane oxygenation: incidence, etiology, and impact on patients’ outcome. Crit Care Med 2017;45:17261733.
7. Garner, JS, Jarvis, WR, Emori, TG, Horan, TC, Hughes, JM. CDC definitions for nosocomial infections, 1988. Am J Infect Control 1988;16:128140.
8. Horan, TC, Andrus, M, Dudeck, MA. CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control 2008;36:309332.
9. Aubron, C, Cheng, AC, Pilcher, D, et al. Factors associated with outcomes of patients on extracorporeal membrane oxygenation support: a 5-year cohort study. Crit Care 2013;17:R73.
10. Sun, HY, Ko, WJ, Tsai, PR, et al. Infections occurring during extracorporeal membrane oxygenation use in adult patients. J Thorac Cardiovasc Surg 2010;140:11251132.
11. Hsu, MS, Chiu, KM, Huang, YT, Kao, KL, Chu, SH, Liao, CH. Risk factors for nosocomial infection during extracorporeal membrane oxygenation. J Hosp Infect 2009;73:210216.
12. Brown, KL, Ridout, DA, Shaw, M, et al. Healthcare-associated infection in pediatric patients on extracorporeal life support: the role of multidisciplinary surveillance. Pediatr Crit Care Med 2006;7:546550.
13. Steiner, CK, Stewart, DL, Bond, SJ, Hornung, CA, McKay, VJ. Predictors of acquiring a nosocomial bloodstream infection on extracorporeal membrane oxygenation. J Pediatr Surg 2001;36:487492.
14. Aubron, C, Cheng, AC, Pilcher, D, et al. Infections acquired by adults who receive extracorporeal membrane oxygenation: risk factors and outcome. Infect Control Hosp Epidemiol 2013;34:2430.
15. Kim, DW, Yeo, HJ, Yoon, SH, et al. Impact of bloodstream infections on catheter colonization during extracorporeal membrane oxygenation. J Artif Organs 2016;19:128133.
16. Thomas, G, Hraiech, S, Cassir, N, et al. Venovenous extracorporeal membrane oxygenation devices-related colonisations and infections. Ann Intensive Care 2017;7:111.
17. O’Horo, JC, Maki, DG, Krupp, AE, Safdar, N. Arterial catheters as a source of bloodstream infection: a systematic review and meta-analysis. Crit Care Med 2014;42:13341339.
18. Taylor, RW, O’Brien, J, Trottier, SJ, et al. Red blood cell transfusions and nosocomial infections in critically ill patients. Crit Care Med 2006;34:23022308; quiz 2309.
19. Butch, SH, Knafl, P, Oberman, HA, Bartlett, RH. Blood utilization in adult patients undergoing extracorporeal membrane oxygenated therapy. Transfusion 1996;36:6163.
Type Description Title
Supplementary materials

Na et al. supplementary material
Figure S1 and Table S1

 Word (97 KB)
97 KB


Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed