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Clinical, Microbiological, and Economic Benefit of a Change in Antibiotic Prophylaxis for Cardiac Surgery

  • Denis Spelman (a1), Glenys Harrington (a1), Phil Russo (a1) and S. Wesselingh (a1)

Abstract

Vancomycin and rifampicin replaced cephazolin as antibiotic prophylaxis for coronary artery bypass surgery at our institution. Following this intervention, there was a significant decrease (P < .001) in the surgical-site infection rate from 10.5 (95% confidence interval, 8.2 to 13.3) to 4.9 (95% confidence interval, 3.2 to 7.1) infections per 100 procedures. An estimated $576,655 (Australian) was saved between two 12-month periods.

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Corresponding author

Microbiology, Alfred Hospital, Commercial Road, Prahran 3181, Australia

References

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Clinical, Microbiological, and Economic Benefit of a Change in Antibiotic Prophylaxis for Cardiac Surgery

  • Denis Spelman (a1), Glenys Harrington (a1), Phil Russo (a1) and S. Wesselingh (a1)

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