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  • Infection Control & Hospital Epidemiology, Volume 32, Issue 4
  • April 2011, pp. 387-390

Comparison of the Burdens of Hospital-Onset, Healthcare Facility-Associated Clostridium difficile Infection and of Healthcare-Associated Infection due to Methicillin-Resistant Staphylococcus aureus in Community Hospitals

  • Becky A. Miller (a1), Luke F. Chen (a1), Daniel J. Sexton (a1) and Deverick J. Anderson (a1)
  • DOI:
  • Published online: 02 January 2015

We sought to determine the burden of nosocomial Clostridium difficile infection in comparison to other healthcare-associated infections (HAIs) in community hospitals participating in an infection control network. Our data suggest that C. difficilehas replaced MRSA as the most common etiology of HAI in community hospitals in the southeastern United States.

Corresponding author
Box 102359, Duke University Medical Center, Durham, NC 27710 (
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1.RM Dallal , BG Harbrecht , AJ Boujoukas , et al.Fulminant Clostridium difficile: an underappreciated and increasing cause of death and complications. Ann Surg 2002;235:363372.

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3.DM Musher , S Aslam , N Logan , et al.Relatively poor outcome after treatment of Clostridium difficile colitis with metronidazole. Clin Infect Dis 2005;40:15861590.

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7.TC Horan , M Andrus , MA Dudeck . CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control 2008;36:309332.

10.KS Kaye , R Sloane , DJ Sexton , KA Schmader . Risk factors for surgical site infections in older people. J Am Geriatr Soc 2006;54:391396.

11.LC McDonald , GE Killgore , A Thompson , et al. An epidemic, toxin gene-variant strain of Clostridium difficile. N Engl J Med 2005;353:24332441.

12.VG Loo , MD Libman , MA Miller , et al.Clostridium difficile, a formidable foe. CMAJ 2004;171:4748.

13.VG Loo , L Poirier , MA Miller , et al.A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality. N Engl J Med 2005;353:24422449.

15.JR O'Connor , S Johnson , DN Gerding . Clostridium difficile infection caused by the epidemic BI/NAP1/027 strain. Gastroenterology 2009;136:19131924.

16.AJ Kallen , Y Mu , S Bulens , et al.Health care-associated invasive MRSA infections, 2005-2008. JAMA 2010;304:641647.

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Infection Control & Hospital Epidemiology
  • ISSN: 0899-823X
  • EISSN: 1559-6834
  • URL: /core/journals/infection-control-and-hospital-epidemiology
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