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Bacitracin Versus Mupirocin for Staphylococcus aureus Nasal Colonization

  • Norberto E. Soto (a1), Ashok Vaghjimal (a1), Annette Stahl-Avicolli (a2), John R. Protic (a3), Larry I. Lutwick (a1) and Edward K. Chapnick (a1)...

We performed a randomized prospective study of 5-day treatment with topical mupirocin or bacitracin for the elimination of Staphylococcus aureus nasal colonization in healthcare workers (HCWs). Nasal cultures were obtained from 141 HCWs, 37 (26%) of whom showed S aureus. After 72 to 96 hours of treatment, the organism was eradicated in 15 (94%) of 16 by mupirocin and in 8 (44%) of 18 by bacitracin (P=.0031). Similar efficacy was demonstrated at 30 days. Mupirocin may be more effective than bacitracin for eradication of S aureus in healthy HCWs.

Corresponding author
Maimonides Medical Center, 4802 Tenth Ave, Brooklyn, NY 11219
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Infection Control & Hospital Epidemiology
  • ISSN: 0899-823X
  • EISSN: 1559-6834
  • URL: /core/journals/infection-control-and-hospital-epidemiology
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