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Outbreak of Carbapenem-Resistant Providencia stuartii in an Intensive Care Unit

Published online by Cambridge University Press:  02 January 2015

Alexandre P. Zavascki*
Affiliation:
Infectious Diseases Service, Hospital de Clínicas de Porto Alegre, Brazil
Cecília G. Carvalhaes
Affiliation:
Laboratório ALERTA, Division of Infectious Diseases, Universidade Federal de São Paulo, São Paulo, Brazil
Geórgia L. da Silva
Affiliation:
Infection Control Service, Hospital São Lucas da Pontificia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil
Sílvia Pedroso Tavares Soares
Affiliation:
Infection Control Service, Hospital São Lucas da Pontificia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil
Luciana R. de Alcåntara
Affiliation:
Infection Control Service, Hospital São Lucas da Pontificia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil
Laura S. Elias
Affiliation:
Infection Control Service, Hospital São Lucas da Pontificia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil
Ana M. Sandri
Affiliation:
Infection Control Service, Hospital São Lucas da Pontificia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil
Ana C. Gales
Affiliation:
Laboratório ALERTA, Division of Infectious Diseases, Universidade Federal de São Paulo, São Paulo, Brazil
*
Alexandre P. Zavascki, MD, PhD, Infectious Diseases Service, Hospital de Clínicas de Porto Alegre, 2350 Ramiro Barcelos Street, Porto Alegre 90.035-903, Brazil (azavascki@hcpa.ufrgs.br)

Abstract

Outbreaks by carbapenem-resistant Providencia stuartii (CRPS) are rarely described. Clinical characteristics of patients with CRPS in an intensive care unit and resistance mechanisms were investigated. Carbapenemase production and/or outer membrane alterations were not detected; only CTX-M-2 and AmpC hyperproduction were noted. The outbreak was ultimately controlled in a 3-month period.

Type
Concise Communication
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2012 

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References

1. Lee, HW, Kang, HY, Shin, KS, Kim, J. Multidrug-resistant Providencia isolates carrying blaPER-1, blaVIM-2, and armA. J Microbiol 2007;45:272274.Google Scholar
2. Miriagou, V, Tzouvelekis, LS, Flevari, K, Tsakiri, M, Douzinas, EE. Providencia stuartii with VIM-1 metallo-β-lactamase. J Anti-microb Chemother 2007;60:183184.Google Scholar
3. Shiroto, K, Ishii, Y, Kimura, S, et al. Metallo-β-lactamase IMP-1 in Providencia rettgeri from two different hospitals in Japan. J Med Microbiol 2005;54:10651070.Google Scholar
4. Horan, TC, Andrus, M, Dudeck, MA. CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control 2008;36:309332.Google Scholar
5. Clinical and Laboratory Standards Institute. 2009. Performance standards for antimicrobial susceptibility testing. CLSI document M100-S19. Clinical and Laboratory Standards Institute, Wayne, PA.Google Scholar
6. Thomson, KS. Extended-spectrum-β-lactamase, AmpC, and car-bapenemase issues. J Clin Microbiol 2010;48:10191025.Google Scholar
7. Tenover, FC, Arbeit, RD, Goering, RV, et al. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J Clin Microbiol 1995;33:22332239.Google Scholar
8. Poirel, L, Naas, T, Guibert, M, EB, Chaibi, Labia, R, Nordmann, P. Molecular and biochemical characterization of VEB-1, a novel class A extended-spectrum β-lactamase encoded by an Escherichia coli integran gene. Antimicrob Agents Chemother 1999;43: 573581.Google Scholar
9. Picão, RC, Poirel, L, Gales, AC, Nordmann, P. Diversity of β-lactamases produced by ceftazidime-resistant Pseudomonas aeru ginosa causing bloodstream infections in Brazil. Antimicrob Agents Chemother 2009;53:39083913.Google Scholar
10. Pérez-Pérez, FJ, Hanson, ND. Detection of plasmid-mediated AmpC β-lactamase genes in clinical isolates by using multiplex PCR. J Clin Microbiol 2002;40:21532162.Google Scholar
11. Hernandez-Allés, S, Albertí, S, Alvarez, D, et al. Porin expression in clinical isolates of Klebsiella pneumoniae . Microbiology 1999; 145:673679.Google Scholar
12. Tran, QT, Mahendran, KR, Hajjar, E, et al. Implication of porins in β-lactam resistance of Providencia stuartii . J Biol Chem 2010; 285:3227332281.Google Scholar