Skip to main content

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
Cancel
×
×
Home
  • Home
Article

Effects of Chlorhexidine Oral Decontamination on Respiratory Colonization during Mechanical Ventilation in Intensive Care Unit Patients

  • Douwe F. Postma (a1), Sanjay U. C. Sankatsing (a1), Steven F. T. Thijsen (a2) and Henrik Endeman (a3)
Abstract

We conducted a retrospective cohort study to assess respiratory colonization before and after the use of chlorhexidine oral decontamination among a cohort of intensive care unit patients who received mechanical ventilation. We observed a decrease in the prevalence of Enterobacteriaceae and an increase in the incidence of fungal colonization. Chlorhexidine oral decontamination might have a differential effect on respiratory colonization.

Copyright
COPYRIGHT: © The Society for Healthcare Epidemiology of America 2012
Corresponding author
University Medical Centre Utrecht, Julius Center for Health Sciences, PO Box 85500, 3508 GA, Utrecht, the Netherlands (d.f.postma@umcutrecht.nl)
References
Hide All
1.Safdar, N, Dezfulian, C, Collard, HR, Saint, S. Clinical and economic consequences of ventilator-associated pneumonia: a systematic review. Crit Care Med 2005;33(10):2184–2193.
2. Garrouste-Org, Chevret, S, Arlet, G, et al. Oropharyngeal or gastric colonization and nosocomial pneumonia in adult intensive care unit patients: a prospective study based on genomic DNA analysis. Am J Respir Crit Care Med 1997;156(5):1647–1655.
3.de Smet, AM, Kluytmans, JA, Cooper, BS, et al. Decontamination of the digestive tract and oropharynx in ICU patients. N Engl J Med 2009;360(1):20–31.
4.de la Cal, MA, Cerda, E, Garcia-Hierro, P, et al. Pneumonia in patients with severe burns: a classification according to the concept of the carrier state. Chest 2001;119(4):1160–1165.
5.Koeman, M, van der Ven, AJ, Hak, E, et al. Oral decontamination with Chlorhexidine reduces the incidence of ventilator-associated pneumonia. Am JRespir Crit Care Med 2006;173(12):1348–1355.
6.Tantipong, H, Morkchareonpong, C, Jaiyindee, S, Thamlikitkul, V. Randomized controlled trial and meta-analysis of oral decontamination with 2% Chlorhexidine solution for the prevention of ventilator-associated pneumonia. Infect Control Hosp Epidemiol 2008;29(2):131–136.
7.Bellissimo-Rodrigues, F, Bellissimo-Rodrigues, WT, Viana, JM, et al. Effectiveness of oral rinse with Chlorhexidine in preventing nosocomial respiratory tract infections among intensive care unit patients. Infect Control Hosp Epidemiol 2009;30(10): 952–958.
8.Scannapieco, FA, Yu, J, Raghavendran, K, et al. A randomized trial of Chlorhexidine gluconate on oral bacterial pathogens in mechanically ventilated patients. Crit Care 2009;13(4):R117.
9.Lim, KS, Kam, PC. Chlorhexidine: pharmacology and clinical applications. Anaesth Intensive Care 2008;36(4):502–512.
10.Reichel, M, Heisig, P, Kampf, G. Pitfalls in efficacy testing-how important is the validation of neutralization of Chlorhexidine digluconate? Ann Clin Microbiol Antimicrob 2008;7:20.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Infection Control & Hospital Epidemiology
  • ISSN: 0899-823X
  • EISSN: 1559-6834
  • URL: /core/journals/infection-control-and-hospital-epidemiology
Please enter your name
Please enter a valid email address
Who would you like to send this to? *

CAPTCHA *

Skip to the audio challenge
×

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 43 *
Loading metrics...

Abstract views

Total abstract views: 171 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 12th June 2018. This data will be updated every 24 hours.

Cancel
Confirm
×