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Efficacy of a Novel Light-Activated Antimicrobial Coating for Disinfecting Hospital Surfaces

  • Salim Ismail (a1), Stefano Perni (a1), Jonathan Pratten (a1), Ivan Parkin (a2) and Michael Wilson (a1)...

Silicone polymers containing the light-activated antimicrobial agent methylene blue with or without gold nanoparticles were evaluated for their ability to reduce the microbial load on surfaces in a clinical environment. When irradiated with white light, polymers containing nanogold were more effective in this respect than those containing only methylene blue.

Corresponding author
Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, 256 Gray's Inn Road, London WCIX 8LD, United Kingdom (
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1. V Decraene , J Pratten , M Wilson . Cellulose acetate containing toluidine blue and rose bengal is an effective antimicrobial coating when exposed to white light. Appl Environ Microbiol 2006;72:44364439.

2. S Perni , C Piccirillo , J Pratten , et al. The antimicrobial properties of light-activated polymers containing methylene blue and gold nanoparticles. Biomaterials 2009;30:8993.

4. S Murchan , H Aucken , GL O'Neill , et al. Emergence, spread, and characterization of phage variants of epidemic methicillin-resistant Staphylococcus aureus 16 in England and Wales. J Clin Microbiol 2004;42:51545160.

6. MN Usacheva , MC Teichert , MA Biel . Comparison of the methylene blue and toluidine blue photobactericidal efficacy against gram-positive and gram-negative microorganisms. Lasers Surg Med 2001;29:165173.

7. V Decraene , J Pratten , M Wilson . Novel light-activated antimicrobial coatings are effective against surface-deposited Staphylococcus aureus. Curr Microbiol 2008;57:269273.

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Infection Control & Hospital Epidemiology
  • ISSN: 0899-823X
  • EISSN: 1559-6834
  • URL: /core/journals/infection-control-and-hospital-epidemiology
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