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Epidemiology of Sepsis in the Valencian Community (Spain), 1995–2004

  • Juan Carlos Andreu Ballester (a1), Ferran Ballester (a2), Antonio González Sánchez (a3), Amadeo Almela Quilis (a1), Enrique Colomer Rubio (a1) and Carlos Peñarroja Otero (a4)...

Abstract

Objective.

To study the incidence of sepsis in the Valencian Community (Spain) during a period of 10 years (1995–2004).

Methods.

We downloaded data on discharge diagnoses of septicemia in all 26 public hospitals in the Valencian Community during the 10-year study period, as well as the additional discharge diagnoses of each patient.

Results.

We identified 33,767 cases of sepsis during the study period. The age-standardized incidence rates among men increased from 64.11 (95% confidence interval [CI], 60.37–67.85) cases per 100,000 population in 1995 to 114.02 (95% CI, 109.02–118.50) cases per 100,000 population in 2004 (P < .001), and those among women increased from 45.08 (95% CI, 42.01–48.15) cases per 100,000 population in 1995 to 83.62 (95% CI, 79.85–87.39) cases per 100,000 population in 2004 (P < .001). Gram-negative bacteria were the most frequently involved microorganisms (in 21.4% of cases), and there was a significant increase in the number of sepsis cases caused by these organisms from 1999 onward. The mortality rate was approximately 42.5% among patients hospitalized for sepsis, and mortality was associated with organ failure. In addition, mortality was associated with the microorganism responsible not being known, with infection due to fungi, and with polymicrobial sepsis.

Conclusions.

The rates of hospitalization both for sepsis overall and for severe sepsis in the Valencian Community (Spain) are lower than those in other countries but are increasing, by 5% each year. The increase in the number of cases in which gram-negative bacteria are the cause of sepsis is notable.

Copyright

Corresponding author

San Clemente 12, Valencia 46015, Spain (jcandreu@ono.com)

References

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1.Martin, GS, Mannino, DM, Eaton, S, Moss, M. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003;348:15461554.
2.Angus, DC, Linde-Zwirble, WT, Lidicker, J, Clermont, G, Carcillo, J, Pinsky, MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001;29:1303— 1310.
3.Dombrovskiy, VY, Martin, AA, Sunderram, J, Paz, HL. Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003. Crit Care Med 2007;35:12441250.
4.Osborn, TM, Nguyen, HB, Rivers, EP. Emergency medicine and the surviving sepsis campaign: an international approach to managing severe sepsis and septic shock. Ann Emerg Med 2005;46:228231.
5.Dellinger, RP, Carlet, JM, Masur, H. Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Intensive Care Med 2004;30:536555.
6.Nguyen, HB, Rivers, EP, Abrahamian, FM, et al. Severe sepsis and septic shock: review of the literature and emergency department management guidelines. Ann Emerg Med 2006;48:2854.
7.Brun-Buisson, C, Roudot-Thoraval, F, Girou, E, Grenier-Sennelier, C, Durand-Zaleski, I. The costs of septic syndromes in the intensive care unit and influence of hospital-acquired sepsis. Intensive Care Med 2003;29:14641471.
8.Adrie, C, Alberti, C, Chaix-Couturier, C, et al. Epidemiology and economic evaluation of severe sepsis in France: age, severity, infection site, and place of acquisition (community, hospital, or intensive care unit) as determinants of workload and cost. J Crit Care 2005;20:4658.
9.Ifligo, J, Sendra, JM, Diaz, R, Bouza, C, Sarria-Santamera, A. Epidemiology and costs of severe sepsis in Madrid: a hospital discharge study [in Spanish]. Medlntensiva 2006;30:197203.
10.Rivers, EP, Nguyen, HB, Amponsah, D. Sepsis: a landscape from the emergency department to the intensive care unit. Crit Care Med 2003;31:968969.
11.Strehlow, MC, Emond, SD, Shapiro, NI, et al. National study of emergency department visits for sepsis, 1992 to 2001. Ann Emerg Med 2006;48:326331, 331.e1–3.
12.Abraham, E, Matthay, MA, Dinarello, CA, et al. Consensus conference definitions for sepsis, septic shock, acute lung injury, and acute respiratory distress syndrome: time for a reevaluation. Crit Care Med 2000;28:232235.
13.Bone, RC, Balk, RA, Cerra, FB, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992;101:16441655.
14.Trichopoulou, A, Orfanos, P, Norat, T, et al. Modified Mediterranean diet and survival: EPIC-elderly prospective cohort study. BMJ 2005;330:991.
15.Helsing, E. Traditional diets and disease patterns of the Mediterranean, circa 1960. Am J Clin Nutr 1995;61(Suppl 6):1329S–1337S.
16.Lowy, FD. Staphylococcus aureus infections. N Engl J Med 1998;339:520532.
17.Lazaro Bengoa, E, Madurga Sanz, M, de Abajo Iglesias, FJ. Evolutión del consumo de antibióticos en España, 1985-2000. Med Clin (Bare) 2002;118:561568.
18.Cars, O, Mölstad, S, Melander, A. Variation in antibiotic use in the European Union. Lancet 2001;357:18511853.
19.Directión General de Aseguramiento y Planificación Sanitaria. Agencia de Evaluación de Tecnologías Sanitarias. Ministerio de Sanidad y Consumo. Informe sobre resistencia microbiana: jqué hacer? Med Clin (Bare) 1995;106:267279.
20.Smith, RD, Coast, J. Antimicrobial resistance: a global response. Bull World Health Organ 2002;80:126133.
21.Osborn, TM, Tracy, KJ, Dunne, JR. Epidemiology of sepsis in patients with traumatic injury. Crit Care Med 2004;32:22342240.
22.Rangel-Frausto, MS. The epidemiology of bacterial sepsis. Infect Dis Clin North Am 1999;13:299312, vii.
23.Brun-Buisson, C, Meshaka, P, Pinton, P, Vallet, B, EPISEPSIS Study Group. EPISEPSIS: a reappraisal of the epidemiology and outcome of severe sepsis in French intensive care units. Intensive Care Med 2004;30:580588.
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Infection Control & Hospital Epidemiology
  • ISSN: 0899-823X
  • EISSN: 1559-6834
  • URL: /core/journals/infection-control-and-hospital-epidemiology
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