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  • Infection Control & Hospital Epidemiology, Volume 32, Issue 2
  • February 2011, pp. 101-114

Estimating the Proportion of Healthcare-Associated Infections That Are Reasonably Preventable and the Related Mortality and Costs

  • Craig A. Umscheid (a1) (a2) (a3), Matthew D. Mitchell (a1), Jalpa A. Doshi (a1) (a3), Rajender Agarwal (a1), Kendal Williams (a1) (a3) and Patrick J. Brennan (a2) (a3) (a4)
  • DOI:
  • Published online: 01 January 2015

To estimate the proportion of healthcare-associated infections (HAIs) in US hospitals that are “reasonably preventable,” along with their related mortality and costs.


To estimate preventability of catheter-associated bloodstream infections (CABSIs), catheter-associated urinary tract infections (CAUTIs), surgical site infections (SSIs), and ventilator-associated pneumonia (VAP), we used a federally sponsored systematic review of interventions to reduce HAIs. Ranges of preventability included the lowest and highest risk reductions reported by US studies of “moderate” to “good” quality published in the last 10 years. We used the most recently published national data to determine the annual incidence of HAIs and associated mortality. To estimate incremental cost of HAIs, we performed a systematic review, which included costs from studies in general US patient populations. To calculate ranges for the annual number of preventable infections and deaths and annual costs, we multiplied our infection, mortality, and cost figures with our ranges of preventability for each HAI.


AS many as 65%–70% of cases of CABSI and CAUTI and 55% of cases of VAP and SSI may be preventable with current evidence-based strategies. CAUTI may be the most preventable HAI. CABSI has the highest number of preventable deaths, followed by VAP. CABSI also has the highest cost impact; costs due to preventable cases of VAP, CAUTI, and SSI are likely less.


Our findings suggest that 100% prevention of HAIs may not be attainable with current evidence-based prevention strategies; however, comprehensive implementation of such strategies could prevent hundreds of thousands of HAIs and save tens of thousands of lives and billions of dollars.

Corresponding author
Assistant Professor of Medicine and Epidemiology, Director, Center for Evidence-Based Practice, University of Pennsylvania, 3535 Market Street, Mezzanine, Suite 50, Philadelphia, PA 19104 (
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9.S Harbarth , H Sax , P Gastmeier . The preventable proportion of nosocomial infections: An overview of published reports. J Hosp Infect 2003;54(4):258266.

10.RP Shannon , B Patel , D Cummins , AH Shannon , G Ganguli , Y Lu . Economics of central line-associated bloodstream infections. Am J Med Qual 2006;21(suppl 6):7S16S.

11.DK Warren , WW Quadir , CS Hollenbeak , AM Elward , MJ Cox , VJ Fraser . Attributable cost of catheter-associated bloodstream infections among intensive care patients in a nonteaching hospital. Crit Care Med 2006;34(8):20842089.

12.JB Dimick , RK Pelz , R Consunji , SM Swoboda , CW Hendrix , PA Lipsett . Increased resource use associated with catheter-related bloodstream infection in the surgical intensive care unit. Arch Surg 2001;136(2):229234.

13.T Lansford , M Moncure , E Carlton , et al.Efficacy of a pneumonia prevention protocol in the reduction of ventilator-associated pneumonia in trauma patients. Surg Infect (Larchmt) 2007;8(5):505510.

17.RA Bologna , LM Tu , M Polansky , HD Fraimow , DA Gordon , KE Whitmore . Hydrogel/silver ion-coated urinary catheter reduces nosocomial urinary tract infection rates in intensive care unit patients: a multicenter study. Urology 1999;54(6):982987.

18.JB Dimick , SL Chen , PA Taheri , WG Henderson , SF Khuri , DA Campbell Jr. Hospital costs associated with surgical complications: a report from the private-sector national surgical quality improvement program. J Am Coll Surg 2004;199(4):531537.

23.D Pittet , S Harbarth . What techniques for diagnosis of ventilator-associated pneumonia? [see comment]. Lancet 1998; 352(9122):8384.

26.P Pronovost , D Needham , S Berenholtz , et al.An intervention to decrease catheter-related bloodstream infections in the ICU. N Engl J Med 2006;355(26):27252732.

27.SM Berenholtz , PJ Pronovost , PA Lipsett , et al.Eliminating catheter-related bloodstream infections in the intensive care unit. Crit Care Med 2004;32(10):20142020.

28.CM Coopersmith , JE Zack , MR Ward , et al.The impact of bedside behavior on catheter-related bacteremia in the intensive care unit. Arch Surg 2004;139(2):131136.

29.DK Warren , JE Zack , JL Mayfield , et al.The effect of an education program on the incidence of central venous catheter-associated bloodstream infection in a medical ICU. Chest 2004; 126(5):16121618.

30.DK Warren , JE Zack , MJ Cox , MM Cohen , VJ Fraser . An educational intervention to prevent catheter-associated bloodstream infections in a nonteaching, community medical center. Crit Care Med 2003;31(7):19591963.

31.CM Coopersmith , TL Rebmann , JE Zack , et al.Effect of an education program on decreasing catheter-related bloodstream infections in the surgical intensive care unit. Crit Care Med 2002; 30(1):5964.

32.RJ Sherertz , EW Ely , DM Westbrook , et al.Education of physicians-in-training can decrease the risk for vascular catheter infection. Ann Intern Med 2000;132(8):641648.

33.HM Babcock , JE Zack , T Garrison , et al.An educational intervention to reduce ventilator-associated pneumonia in an integrated health system: a comparison of effects. Chest 2004;125(6):22242231.

34.JE Zack , T Garrison , E Trovillion , et al.Effect of an education program aimed at reducing the occurrence of ventilator-associated pneumonia. Crit Care Med 2002;30(11):24072412.

36.J Topal , S Conklin , K Camp , V Morris , T Balcezak , P Herbert . Prevention of nosocomial catheter-associated urinary tract infections through computerized feedback to physicians and a nurse-directed protocol. Am J Med Qual 2005;20(3):121126.

40.N Rao , D Schilling , J Rice , M Ridenour , W Mook , E Santa . Prevention of postoperative mediastinitis: a clinical process improvement model. J Healthc Qual 2004;26(1):2227.

45.EN Perencevich , KE Sands , SE Cosgrove , E Guadagnoli , E Meara , R Platt . Health and economic impact of surgical site infections diagnosed after hospital discharge. Emerg Infect Dis 2003;9(2):196203.

46.JB Dimick , PJ Pronovost , JA Cowan , PA Lipsett . Complications and costs after high-risk surgery: where should we focus quality improvement initiatives? J Am Coll Surg 2003;196(5):671678.

47.LA Herwaldt , SK Swartzendruber , MB Edmond , et al.The epidemiology of hemorrhage related to cardiothoracic operations. Infect Control Hosp Epidemiol 1998;19(1):916.

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  • EISSN: 1559-6834
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