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Failure of Oral Antimicrobial Agents in Eradicating Gastrointestinal Colonization With Vancomycin-Resistant Enterococci

  • Ray Hachem (a1) and Issam Raad (a1)


Eradication of gastrointestinal colonization with vancomycin-resistant enterococci (VRE) using a combination of oral bacitracin and gentamicin was evaluated. Twenty-eight evaluable treated patients were matched with 28 control patients. After 3 months of follow-up, 5 patients (18%) in the treatment group versus 1 patient (4%) in the control group (P = .2) had negative results on stool cultures, with a similar frequency of VRE bacteremia (P = .8). The use of oral bacitracin plus gentamicin did not reduce VRE colonization or bacteremia.


Corresponding author

Professor of Medicine, The University of Texas M.D. Anderson Cancer Center, Department of Infection Diseases, Infection Control and Employee Health (Box 402), 1515 Holcombe Blvd., Houston, TX 77030


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