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Feasibility of Azithromycin Prophylaxis During a Pertussis Outbreak Among Healthcare Workers in a University Hospital in Paris

Published online by Cambridge University Press:  21 June 2016

Camila Giugliani ,
Gwenaëlle Vidal-Trécan ,
Souleymane Traore ,
Hervé Blanchard ,
Gabriela Spiridon ,
Florence Rollot ,
Odile Launay ,
Myriam Gorodestski ,
Jean-Luc Marande  and
Christophe Vinsonneau
...Show all authors
Camila Giugliani
Affiliation:
Service de Santé Publique, Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France Groupe Hospitalier Cochin–St. Vincent de Paul, AP-HP, and the Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France
Gwenaëlle Vidal-Trécan
Affiliation:
Service de Santé Publique, Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France Groupe Hospitalier Cochin–St. Vincent de Paul, AP-HP, and the Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France
Souleymane Traore
Affiliation:
Service de Médecine Interne, Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France
Hervé Blanchard
Affiliation:
Service d'Hygiène Hospitalière, Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France
Gabriela Spiridon
Affiliation:
Service de Médecine Interne, Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France
Florence Rollot
Affiliation:
Service de Médecine Interne, Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France Groupe Hospitalier Cochin–St. Vincent de Paul, AP-HP, and the Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France
Odile Launay
Affiliation:
Service de Médecine Interne, Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France Groupe Hospitalier Cochin–St. Vincent de Paul, AP-HP, and the Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France
Myriam Gorodestski
Affiliation:
Service de Médecine du Travail, Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France
Jean-Luc Marande
Affiliation:
Service de Médecine du Travail, Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France
Christophe Vinsonneau
Affiliation:
Service d'Hygiène Hospitalière, Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France
Loïc Guillevin
Affiliation:
Service de Médecine Interne, Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France Groupe Hospitalier Cochin–St. Vincent de Paul, AP-HP, and the Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France
Dominique Salmon-Céron*
Affiliation:
Service de Médecine Interne, Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France Groupe Hospitalier Cochin–St. Vincent de Paul, AP-HP, and the Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France
*
Service de Médecine Interne Unité de Maladies Infectieuses, Groupe Hospitalier Cochin–St. Vincent de Paul, 27, rue du Faubourg Saint Jacques 75014 Paris, France (dominique.salmon@cch.ap-hop-paris.fr)
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Abstract

The objective of the present study was to evaluate the feasibility of azithromycin prophylaxis with respect to tolerability and compliance during a pertussis outbreak among healthcare workers in a university hospital ward. Compliance with the prophylaxis regimen was 89%; compliance was 75% from intent-to-treat perspective. The rate of adverse events was 33%. Female sex was associated with reporting of adverse events. Nonstudents and healthcare workers who reported adverse events were less compliant with the prophylaxis regimen.

Type
Concise Communications
Information
Infection Control & Hospital Epidemiology , Volume 27 , Issue 6 , June 2006 , pp. 626 - 629
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2006

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References

1.Christie, CD, Marx, ML, Marchant, CD, Reising, SF. The 1993 epidemic of pertussis in Cincinnati: resurgence of disease in a highly immunized population of children. N Engl J Med 1994; 331:16–21.Google Scholar
2.Guris, D, Strebel, PM, Bardenheier, B, et al. Changing epidemiology of pertussis in the United States: increasing reported incidence among adolescents and adults, 1990-1996. Clin Infect Dis 1999;28:1230–1237.CrossRefGoogle ScholarPubMed
3.Gilberg, S, Njamkepo, E, Du, C, et al. Evidence of Bordetella pertussis infection in adults presenting with persistent cough in a French area with very high whole-cell vaccine coverage. J Infect Dis 2002; 186:415–418.CrossRefGoogle Scholar
4.Aoyama, T, Harashima, M, Nishimura, K, Saito, Y. Outbreak of pertussis in highly immunized adolescents and its secondary spread to their families. Acta Paediatr Jpn 1995; 37:321–324.Google Scholar
5.von Konig, CH, Halperin, S, Riffelmann, M, Guiso, N. Pertussis of adults and infants. Lancet Infect Dis 2002; 2:744–750.Google Scholar
6.Nelson, JD. The changing epidemiology of pertussis in young infants: the role of adults as reservoirs of infection. Am J Dis Child 1978; 132:371–373.Google Scholar
7.Wright, SW, Decker, MD, Edwards, KM. Incidence of pertussis infection in healthcare workers. Infect Control Hosp Epidemiol 1999; 20:120–123.Google Scholar
8.Ward, A, Caro, J, Bassinet, L, Housset, B, O'Brien, JA, Guiso, N. Health and economic consequences of an outbreak of pertussis among healthcare workers in a hospital in France. Infect Control Hosp Epidemiol 2005; 26:288–292.Google Scholar
9.Martinez, SM, Kemper, CA, Haiduven, D, Cody, SH, Deresinski, SC. Azithromycin prophylaxis during a hospitalwide outbreak of a pertussis-like illness. Infect Control Hosp Epidemiol 2001; 22:781–783.Google Scholar
10.Bassinet, L, Matrat, M, Njamkepo, E, Aberrane, S, Housset, B, Guiso, N. Nosocomial pertussis outbreak among adult patients and healthcare workers. Infect Control Hosp Epidemiol 2004; 25:995–997.Google Scholar
11.Forsyth, KD, Campins-Marti, M, Caro, J, et al. New pertussis vaccination strategies beyond infancy: recommendations by the global pertussis initiative. Clin Infect Dis 2004; 39:1802–1809.Google Scholar
12. Rapport du Conseil Supérieur d'Hygiène Publique de France, Section Maladies Transmissibles: relatif à la conduite à tenir devant un ou plusieurs cas groupés de coqueluche. Direction Générale de la Santé; 2004 Jan 16.Google Scholar
13.Hewlett, EL, Edwards, KM. Clinical practice: pertussis—not just for kids. N Engl J Med 2005; 352:1215–1222.CrossRefGoogle ScholarPubMed
14.Tiwari, T, Murphy, TV, Moran, J. Recommended antimicrobial agents for treatment and postexposure prophylaxis of pertussis. National Immunization Program, Centers for Disease Control and Prevention. MMWR Recomm Rep 2005;54(RR-14):1–16.Google Scholar
15.Hopkins, SJ. Clinical toleration and safety of azithromycin in adults and children. Rev Contemp Pharmacother 1994; 5:383–389.Google Scholar
16.Ruuskanen, O. Safety and tolerability of azithromycin in pediatric infectious diseases: 2003 update. Pediatr Infect Dis J 2004;23(2 Suppl):S135–S139.Google Scholar
17.Macaigne, G, Mokbel, M, Marty, O, De La, LP, Mallet, L. Acute pseudoangiocholitic hepatitis probably induced by azithromycin [in French]. Gastroenterol Clin Biol 2000; 24:969–970.Google ScholarPubMed
18.Suriawinata, A, Min, AD. A 33-year-old woman with jaundice after azithromycin use. Semin Liver Dis 2002; 22:207–210.Google Scholar
19.Purcell, BK, Dooley, DP, Gray, PJ, Hill, KJ, Oliverson, FW. Experience with directly observed prophylaxis using erythromycin in military trainees exposed to pertussis. Mil Med 2004; 169:417–420.CrossRefGoogle ScholarPubMed
20.Anastasio, GD, Little, JM Jr., Robinson, MD, Pettice, YL, Leitch, BB, Norton, HJ. Impact of compliance and side effects on the clinical outcome of patients treated with oral erythromycin. Pharmacotherapy 1994; 14:229–234.Google Scholar