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Feasibility of Azithromycin Prophylaxis During a Pertussis Outbreak Among Healthcare Workers in a University Hospital in Paris

  • Camila Giugliani (a1) (a2), Gwenaëlle Vidal-Trécan (a1) (a2), Souleymane Traore (a3), Hervé Blanchard (a4), Gabriela Spiridon (a3), Florence Rollot (a3) (a2), Odile Launay (a3) (a2), Myriam Gorodestski (a5), Jean-Luc Marande (a5), Christophe Vinsonneau (a4), Loïc Guillevin (a3) (a2) and Dominique Salmon-Céron (a3) (a2)...

The objective of the present study was to evaluate the feasibility of azithromycin prophylaxis with respect to tolerability and compliance during a pertussis outbreak among healthcare workers in a university hospital ward. Compliance with the prophylaxis regimen was 89%; compliance was 75% from intent-to-treat perspective. The rate of adverse events was 33%. Female sex was associated with reporting of adverse events. Nonstudents and healthcare workers who reported adverse events were less compliant with the prophylaxis regimen.

Corresponding author
Service de Médecine Interne Unité de Maladies Infectieuses, Groupe Hospitalier Cochin–St. Vincent de Paul, 27, rue du Faubourg Saint Jacques 75014 Paris, France (
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Infection Control & Hospital Epidemiology
  • ISSN: 0899-823X
  • EISSN: 1559-6834
  • URL: /core/journals/infection-control-and-hospital-epidemiology
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