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Feasibility of Azithromycin Prophylaxis During a Pertussis Outbreak Among Healthcare Workers in a University Hospital in Paris

  • Camila Giugliani (a1) (a2), Gwenaëlle Vidal-Trécan (a1) (a2), Souleymane Traore (a3), Hervé Blanchard (a4), Gabriela Spiridon (a3), Florence Rollot (a3) (a2), Odile Launay (a3) (a2), Myriam Gorodestski (a5), Jean-Luc Marande (a5), Christophe Vinsonneau (a4), Loïc Guillevin (a3) (a2) and Dominique Salmon-Céron (a3) (a2)...
Abstract

The objective of the present study was to evaluate the feasibility of azithromycin prophylaxis with respect to tolerability and compliance during a pertussis outbreak among healthcare workers in a university hospital ward. Compliance with the prophylaxis regimen was 89%; compliance was 75% from intent-to-treat perspective. The rate of adverse events was 33%. Female sex was associated with reporting of adverse events. Nonstudents and healthcare workers who reported adverse events were less compliant with the prophylaxis regimen.

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Corresponding author
Service de Médecine Interne Unité de Maladies Infectieuses, Groupe Hospitalier Cochin–St. Vincent de Paul, 27, rue du Faubourg Saint Jacques 75014 Paris, France (dominique.salmon@cch.ap-hop-paris.fr)
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Infection Control & Hospital Epidemiology
  • ISSN: 0899-823X
  • EISSN: 1559-6834
  • URL: /core/journals/infection-control-and-hospital-epidemiology
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